6期

最新文章

• For reducing premature adult mortality in India, education matters more than income AI翻译
  作者：Dhakad, Moradhvaj; Striessnig, Erich; Saikia, Nandita; Samir, K. C.; Lutz, Wolfgang
  作者单位：International Institute for Applied Systems Analysis (IIASA); Max Planck Society; University of Vienna; University of Vienna; Austrian Academy of Sciences; Shanghai University
  摘要：Preventing premature death is a global policy objective reflected in the SDGs. While numerous studies have found socioeconomic factors to be significantly associated with premature death everywhere in the world, the debate on the relative effect of such factors on mid-age (15 to 59 ages) has not received enough attention, particularly in low-income countries, where this question is pertinent due to scant resources in the healthcare sector. Using nationally representative, longitudinal data fro...
• Single-cell transcriptomics of the Drosophila ring gland identifies the SoxN-Vvl complex as a key regulator of juvenile hormone biosynthesis AI翻译
  作者：Luo, Yuhan; Chen, Nan; Gao, Yue; Luo, Wei; Liu, Shanshan; Li, Yang; Wang, Hanyue; Gao, Xiangbin; Chen, Jiawei; Ye, Haosheng; King-Jones, Kirst; Palli, Subba Reddy; Li, Sheng; Liu, Suning
  作者单位：South China Normal University; Wuhan Business University; University of Alberta; University of Kentucky; South China Normal University
  摘要：Juvenile hormone (JH) is essential for maintaining juvenile status and promoting reproduction in insects, yet the transcriptional regulation of JH biosynthesis remains poorly understood. Previous transcriptomic studies of the Drosophila ring gland-which is composed of the corpus allatum (CA), prothoracic gland (PG), and corpora cardiaca (CC)-have treated the ring gland as a single tissue. As a result, these approaches lacked the resolution necessary to dissect JH biosynthesis and its regulatio...
• Genuine learning biases persist after accounting for temporally decreasing learning rates: Insight from fitting six datasets AI翻译
  作者：Cecchi, Romane; Palminteri, Stefano
  作者单位：Universite PSL; Institut National de la Sante et de la Recherche Medicale (Inserm); Ecole Normale Superieure (ENS)
• Deglacial stratification of the polar Southern Ocean AI翻译
  作者：Fripiat, Francois; Sigman, Daniel M.; Ai, Xuyuan E.; Dumoulin, Cedric; Moretti, Simone; Studer, Anja S.; Diekmann, Bernhard; Esper, Oliver; Frederichs, Thomas; Lamy, Frank; Liu, Ling; Pattyn, Frank; Schmitt, Mareike; Tiedemann, Ralf; Haug, Gerald H.; Martinez-Garcia, Alfredo
  作者单位：Universite Libre de Bruxelles; Max Planck Society; Princeton University; University of Basel; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Bremen; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：It is widely accepted that meltwater from northern ice sheets drove changes in the data are lacking on the Antarctic Ice Sheet's (AIS) effect on Southern Ocean overturning, despite the Southern Ocean's central role in ventilating the ocean interior. Here, we present diatom-bound nitrogen isotope evidence indicating that during deglaciations, as wind-driven upwelling in the open Antarctic Ocean increased, AIS melting strengthened density stratification in the polar Antarctic Ocean. This change ...
• Microraptor reveals specialized gliding capabilities in multiwinged early paravians AI翻译
  作者：Hefler, Csaba; Wang, Ying; Wang, Xiaoli; Zheng, Xiaoting; Kaye, Thomas G.; Grosmougin, Maxime; Chotard, Matthieu; Barlow, Luke; Qiu, Huihe; Dececchi, T. Alexander; Habib, Michael B.; Shyy, Wei; Pittman, Michael
  作者单位：Chinese University of Hong Kong; University of Shanghai for Science & Technology; Linyi University; Hong Kong University of Science & Technology; Dakota State University; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Hong Kong University of Science & Technology
  摘要：Agile and efficient modern flyers like birds and insects rely on complex aerodynamics to increase performance such as leading edge vortices, tip vortices, rapid pitch rotations as well as wing-wake and wing-wing interactions. However, their evolutionary origins are poorly understood. Early birds and their closest relatives like Microraptor had a multiwinged configuration featuring long pennaceous feathers on their arms, legs, and tail, a configuration not seen today. The skill of these early f...
• Evolution of Pliocene-Pleistocene tropical terrestrial Andean temperature amplification AI翻译
  作者：Perez-Angel, Lina C.; Sepulveda, Julio; Molnar, Peter; Mora-Paez, Hector; Parrado, Angelica; Eaman, Katelyn; Russell, James; Rajagopalan, Balaji; Gonzalez-Arango, Catalina; Snell, Kathryn; Montes, Camilo; Crowley, James L.; Schmitz, Mark; Trayler, Robin B.
  作者单位：Brown University; Brown University; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Universidad de Manizales; State University of New York (SUNY) System; University at Albany, SUNY; University at Buffalo, SUNY; University of Colorado System; University of Colorado Boulder; Universidad de los Andes (Colombia); Universidad del Norte Colombia; Boise State University; University of California System; University of California Merced
  摘要：The Pliocene is the most recent epoch in which the Earth warmed under atmospheric CO2 levels similar to today (>400 ppm). The Pliocene then transitioned to the colder Pleistocene epoch, with the initiation of large-scale Northern Hemisphere glaciations. Although ocean temperature changes across these epochs are relatively well-known, quantitative estimates of the magnitude of land temperature change in the tropics are scarce. We provide a Plio-Quaternary quantitative air temperature record bas...
• HSCs/MPPs as cells of origin with altered differentiation hierarchy impairing immunomicroenvironment in PML::RARA and CBFα/β fusion AML AI翻译
  作者：Qiao, Niu; Wang, Zi-Xuan; Zhang, Yu-Liang; Zhang, Liu-Qing-Qing; Zhu, Hong-Ming; Weng, Xiang-Qin; Zhu, Yong-Mei; Cheng, Wen-Yan; Li, Jian-Feng; Jiang, Lu; Yan, Xiao-Yu; Yang, Guang; Shen, Yang; Wang, Sheng-Yue; Chen, Zhu; Sun, Xiao-Jian; Liu, Feng; Chen, Sai-Juan
  作者单位：Shanghai Jiao Tong University; Chinese Academy of Medical Sciences - Peking Union Medical College
  摘要：The theoretical possibility for leukemia stem cells (LSCs) to produce both leukemia blasts and dysfunctional immune cells remains underexplored. Here, we investigate three major fusion transcription factor (fTF)-driven acute myeloid leukemia (AML) subtypes single-cell RNA-sequencing technologies to trace fTF expression in 24 de novo AML patients. We demonstrate that the fTFs are widely expressed not only in leukemia blasts but also in differentiated myeloid and lymphoid cells, indicating hemat...
• Spatial control of myosin regulatory light chain phosphorylation modulates cardiac thick filament mechanosensing AI翻译
  作者：Squarci, Caterina; Koch, Daniel; Anaya, Paul; Campbell, Kenneth S.; Kampourakis, Thomas
  作者单位：University of Kentucky; University of London; King's College London
  摘要：The heart can adapt its performance in response to changing metabolic demands of the rest of the body. A central mechanism intrinsic to the heart is to modulate the function of the cardiac contractile proteins via posttranslational modifications. Although phosphorylation of the cardiac myosin motor-associated regulatory light chain (RLC) by cardiac myosin light chain kinase (cMLCK) has been recognized as a key signaling pathway to increase myocardial contractile function, little is known about...
• Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases (vol 122, e2426890122, 2025) AI翻译
  作者：Curtis, Samuel D.; Liu, Tingshan; Bai, Yuxin; Wang, Yuxuan; Panda, Sambit; Li, Adam; Xu, Haoyin; O'Reilly, Eliza; Dobbyn, Lisa; Popoli, Maria; Ptak, Janine; Silliman, Natalie; Thoburn, Chris; Tie, Jeanne; Gibbs, Peter; Ho-Pham, Lan T.; Tran, Bich N. H.; Tran, Thach S.; Nguyen, Tuan V.; Konig, Maximilian F.; Petri, Michelle; Rosen, Antony; Mecoli, Christopher A.; Shah, Ami A.; Mulder, Frits; Van Es, Nick; Bettegowda, Chetan; Kinzler, Kenneth W.; Papadopoulos, Nickolas; Vogelstein, Joshua T.; Vogelstein, Bert; Douville, Christopher
• Evaluation of targeted and immune combination therapies in a rat model of hormone receptor-positive breast cancer AI翻译
  作者：Rojas-Jimenez, Ernesto; Bui, Triet M.; Yan, Pengze; Li, Zheqi; Seehawer, Marco; Nishida, Jun; Foidart, Pierre; Freeman, Gordon J.; Polyak, Kornelia
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School
  摘要：Estrogen receptor (ER) positive breast cancer is the most prevalent subtype, commonly responsive to endocrine therapies. Immune checkpoint inhibitors (ICIs) have limited efficacy in ER-positive disease, highlighting the need for the development of combination immunotherapies for these patients. We previously established that nitroso-N-methylurea-induced mammary tumors in outbred Sprague-Dawley rats mimic immune evasive mechanisms and the heterogeneity of ICI response observed in patients. We i...