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作者：Anguelovski, Isabelle; Connolly, James J. T.; Corbera, Esteve; Pellow, David N.; Hoover, Fushcia-Ann; Scott, Jacqueline L.; Hendricks, Marccus D.; Schell, Christopher J.
摘要：Across the United States and Europe, urban and periurban spaces have historically been shaped by land dispossession and enclosure that systematically exclude marginalized, non-White communities from the benefits of society, including access to nature. These dynamics, which have played out and perdured over centuries as part of historic land dispossession and recent green racial capitalism, form the bedrock of contemporary urban segregation and socioecological inequalities. As a result, we see ...
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作者：Gulsrud, Natalie M.; Garcia-Antunez, Oriol; Olafsson, Anton S.; Jensen, Marina Bergen
摘要：A key challenge to ensuring no one is left behind in the green transition lies in the persistent segregation of urban populations and the unequal distribution of environmental costs and benefits. Residential segregation has long reinforced socioeconomic and racialized disparities, and climate change introduces new dimensions to these injustices as adaptation policies increasingly shift financial and environmental burdens onto marginalized communities. While housing plays a central role in shap...
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作者：Rohrbach, David; Zhang, Zhuquan; Kurihara, Takayuki; Nelson, Keith A.
作者单位：Massachusetts Institute of Technology (MIT); University of Tokyo
摘要：Nonlinear dynamics govern a wide array of natural phenomena and are essential for understanding nonequilibrium behaviors in condensed matter systems. In magnetically ordered materials, magnons-the quanta of spin waves-exhibit intrinsic nonlinearities that are of great interest in fundamental research and practical applications. Despite progress in the nonlinear control of magnon modes in antiferromagnetic materials, the transition from perturbative to nonperturbative regimes of magnon coherenc...
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作者：Wu, Li; Wu, Jie; Xie, Wenqiang; Lu, Xue; Chen, Chunda; Zhang, Teng; Shen, Jie; Zhao, Yixiao; Chen, Lu; Li, Yeyi; Yu, Qiujing; Fu, Yuan; Wang, Ting
摘要：Cell fate is governed by signaling pathways involving diverse protein modifications. However, how protein AMPylation mediates signal transduction in mammalian cells remains largely unexplored. We demonstrate that the protein adenylyltransferase, SELENOO (SelO), is induced by chemotherapy, and has clinical relevance in cancer. In mice, SelO knockout facilitates primary tumor development and metastasis. In cancer cells, the cytosolic fraction of SelO suppresses cell proliferation and migration. ...
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作者：Gong, Qianqian; Lv, Zhuowen; Dou, Zhilin; Wang, Sen; Zhang, Keyi; Guo, Yuyu; Wang, Yingying; Shao, Ming; Su, Ling; Liu, Xiangguo; Sun, Xiaoyang
作者单位：Shandong University; Shandong University; Shandong University; Shandong University; Shandong University; Shandong University
摘要：Defects in multiciliated ependymal cells (ECs), which line the cerebral ventricular walls and generate unidirectional cerebrospinal fluid (CSF) flow through coordinated ciliary beating, can lead to CSF accumulation and hydrocephalus. TMEM216, a ciliopathy-associated gene mutated in Joubert, Meckel, and related syndromes, encodes an essential component of the protein complexes that form the transition zone (TZ) at the base of primary cilia. Here, we demonstrate that central nervous system-speci...
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作者：Hahn, Michael; Wang, Entang; Wei, Xue-Xin
作者单位：Saarland University; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：Inferring the underlying computational processes from behavioral measurements is a fundamental approach in cognitive science and neuroscience. Although Bayesian decision theory has become a major normative framework for modeling perception and cognition, it is unclear to what extent its modeling components (i.e., prior belief, likelihood function, and loss function) can be recovered from behavioral data. Here, we systematically investigated the problem of inferring such Bayesian models from be...
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作者：Li, Hao; Liu, Bing; Liu, Jiaying; Mangeat, Thomas; Belguise, Karine; Xue, Shi-Lei; Wang, Xiaobo
作者单位：Communaute d'universites et etablissements de Toulouse (Comue); Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse (EPE); Westlake University
摘要：Pulsatile actomyosin networks emerge as a widespread mechanism driving tissue morphogenesis. Compared with myosin-II pulses, F-actin pulses are largely unexplored. By studying Drosophila oogenesis, we report that basal pulsatile actomyosin networks consist of F-actin bundle and meshwork architectures, implicating the existence of different F-actin microstructures and corresponding nucleators. Here, Rac1 and the Scar/WAVE-Arp2/3 complex (branched F-actin nucleator), exhibiting constant levels, ...
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作者：Li, Tiewei; Chen, Hans W.; Chen, Deliang; Xiao, Jingfeng; Guo, Lanlan; Liu, Lianyou; Shi, Feng; Yuan, Wenping; Zhong, Ziqian; Zheng, Huan; He, Bin
作者单位：Tsinghua University; Chalmers University of Technology; Tsinghua University; University System Of New Hampshire; University of New Hampshire; Beijing Normal University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Geology & Geophysics, CAS; Peking University
摘要：With global warming, rising atmospheric vapor pressure deficit (VPD) has emerged as a critical driver of vegetation productivity and the terrestrial carbon sink. Yet, the thresholds beyond which VPD constrains tree growth remain poorly quantified. Using 2,953 tree-ring sites and combining generalized additive models with threshold regression models, we demonstrate that growth-related VPD thresholds are widespread. Approximately 63% of the studied species groups exhibited identifiable threshold...
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作者：Shinkai, Soya; Namba, Toshinori; Sugawara, Takeshi; Hagiwara, Soya; Onami, Shuichi; Haraguchi, Tokuko; Hiraoka, Yasushi; Awazu, Akinori; Ueno, Masaru; Tate, Shin-ichi
作者单位：RIKEN; Hiroshima University; University of Osaka; Hiroshima University; Hiroshima University
摘要：Genome organization in the nucleus is highly structured and dynamic. Recent advances in genomic technology have enabled the measurement of genome-wide architecture and locus-specific motion, yielding contact maps and live-cell trajectories. However, these outcomes are derived from different modalities and are not directly comparable, with their quantitative integration being a key challenge. Here we establish a genome-wide live-cell imaging platform in fission yeast Schizosaccharomyces pombe, ...
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作者：Chen, Jianbin; Lu, Jiuwei; Long, Zhixu; Yoon, Sol; Fukunaga, Megan; Song, Jikui
作者单位：University of California System; University of California Riverside
摘要：DNA methyltransferase DNMT3A-mediated de novo DNA methylation is important for proper regulation of gene expression and genomic stability in development. The DNMT3A R882H (DNMT3AR882H) mutation, a hot-spot mutation in acute myeloid leukemia and developmental disorders, exerts a dominant-negative effect in DNMT3A-mediated DNA methylation through promoting high-order protein assembly. However, due to the lack of structural knowledge on DNMT3A homo-oligomers, the mechanism behind wild-type DNMT3A...
