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作者：Kamii, Yasuhiro; Hayashizaki, Koji; Kanno, Toshio; Chiba, Akio; Ikegami, Taku; Saito, Mitsuru; Akeda, Yukihiro; Ohteki, Toshiaki; Kubo, Masato; Yoshida, Kiyotsugu; Kawakami, Kazuyoshi; Oishi, Kazunori; Araya, Jun; Kuwano, Kazuyoshi; Kronenberg, Mitchell; Endo, Yusuke; Kinjo, Yuki
作者单位：Jikei University; Jikei University; Jikei University; Kazusa DNA Research Institute; Jikei University; Japan Institute for Health Security (JIHS); National Institute of Infectious Diseases (NIID); Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Tokyo University of Science; Jikei University; Tohoku University; La Jolla Institute for Immunology; University of California System; University of California San Diego
摘要：Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that express an invariant T cell receptor alpha chain and contribute to bridging innate and acquired immunity with rapid production of large amounts of cytokines after stimulation. Among effecter subsets of iNKT cells, follicular helper NKT (NKTFH) cells are specialized to help B cells. However, the mechanisms of NKTFH cell differentiation remain to be elucidated. In this report, we studied the mechanism of NKTFH cell differ...
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作者：Krammer, Florian; Palese, Peter
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作者：Pan, Xinyue; Hsiao, Vincent; Nau, Dana S.; Gelfand, Michele J.
作者单位：The Chinese University of Hong Kong, Shenzhen; The Chinese University of Hong Kong, Shenzhen; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; Stanford University; Stanford University
摘要：Gossip, the exchange of personal information about absent third parties, is ubiquitous in human societies. However, the evolution of gossip remains a puzzle. The current article proposes an evolutionary cycle of gossip and uses an agent- based evolutionary game- theoretic model to assess it. We argue that the evolution of gossip is the joint conse-quence of its reputation dissemination and selfishness deterrence functions. Specifically, the dissemination of information about individuals' reput...
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作者：Freedman, Benjamin R.; Cruz, Juan A. Cintron; Kwon, Phoebe; Lee, Matthew; Jeffers, Haley M.; Kent, Daniel; Wu, Kyle C.; Weaver, James C.; Mooney, David J.
作者单位：Harvard University; Harvard University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Massachusetts Institute of Technology (MIT); Rice University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital
摘要：Generating strong rapid adhesion between hydrogels has the potential to advance the capabilities of modern medicine and surgery. Current hydrogel adhesion technologies rely primarily on liquid - based diffusion mechanisms and the formation of covalent bonds, requiring prolonged time to generate adhesion. Here, we present a simple and versatile strategy using dry chitosan polymer films to generate instant adhesion between hydrogel-hydrogel and hydrogel-elastomer surfaces. Using this approach we...
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作者：Iversen, Rasmus; Sollid, Ludvig M.
作者单位：University of Oslo; University of Oslo
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作者：Meyer, Nicholas; Lok, Renske; Schmidt, Christina; Kyle, Simon D.; McClung, Colleen A.; Cajochen, Christian; Scheer, Frank A. J. L.; Jones, Matthew W.; Chellappa, Sarah L.
作者单位：University of London; University College London; University College London Hospitals NHS Foundation Trust; University of London; King's College London; Stanford University; University of Liege; University of Liege; University of Oxford; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Basel; University of Basel; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; University of Bristol; University of Southampton
摘要：Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances can alleviate psychopathology. Conversely, psychiatric symptoms can reciprocally exacerbate poor sleep and disrupt clockcontrolled processes. Despite progress in elucidating underlying mechanisms, a cohesive approach that integr...
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作者：Qi, Yujia; Chang, Shyr-Shea; Wang, Yixuan; Chen, Cynthia; Baek, Kyung In; Hsiai, Tzung; Roper, Marcus
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of Genoa; University of Michigan System; University of Michigan; University System of Georgia; Georgia Institute of Technology; Emory University
摘要：How do vessels find optimal radii? Capillaries are known to adapt their radii to maintain the shear stress of blood flow at the vessel wall at a set point, yet models of adaptation purely based on average shear stress have not been able to produce complex loopy networks that resemble real microvascular systems. For narrow vessels where red blood cells travel in a single file, the shear stress on vessel endothelium peaks sharply when a red blood cell passes through. We show that stable shear -s...
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作者：Wang, Rui; Lei, Huan; Wang, Hongxiang; Qi, Lei; Liu, Yu'e; Liu, Yunhui; Shi, Yufeng; Chen, Juxiang; Shen, Qing-Tao
作者单位：Southern University of Science & Technology; Laoshan Laboratory; Southern University of Science & Technology; Naval Medical University; Shandong University; Tongji University; Tongji University
摘要：Glioblastomas (GBMs) are the most lethal primary brain tumors with limited survival, even under aggressive treatments. The current therapeutics for GBMs are flawed due to the failure to accurately discriminate between normal proliferating cells and distinctive tumor cells. Mitochondria are essential to GBMs and serve as potential therapeutical targets. Here, we utilize cryo- electron tomography to quantitatively investigate nanoscale details of randomly sampled mitochondria in their native cel...
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作者：Farnsworth, Andrew; Horton, Kyle G.; Marra, Peter P.
作者单位：Cornell University; Colorado State University System; Colorado State University Fort Collins; Georgetown University; Georgetown University; Georgetown University
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作者：Ran, Maoxi; Du, Bibai; Liu, Wenyuan; Liang, Zhiyan; Liang, Lihong; Zhang, Yayun; Zeng, Lixi; Xing, Mingyang
作者单位：East China University of Science & Technology; Jinan University; East China University of Science & Technology; East China University of Science & Technology; East China University of Science & Technology
摘要：Creating efficient catalysts for simultaneous H2O2 generation and pollutant degradation is vital. Piezocatalytic H2O2 synthesis offers a promising alternative to traditional methods but faces challenges like sacrificial reagents, harsh conditions, and low activity. In this study, we introduce a cobalt- loaded ZnO (CZO) piezocatalyst that efficiently generates H2O2 from H2O and O-2 under ultrasonic (US) treatment in ambient aqueous conditions. The catalyst demonstrates exceptional performance w...
