Instant tough adhesion of polymer networks
成果类型：
Article
署名作者：
Freedman, Benjamin R.; Cruz, Juan A. Cintron; Kwon, Phoebe; Lee, Matthew; Jeffers, Haley M.; Kent, Daniel; Wu, Kyle C.; Weaver, James C.; Mooney, David J.
署名单位：
Harvard University; Harvard University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Massachusetts Institute of Technology (MIT); Rice University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital
刊物名称：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN/ISSBN：
0027-13980
DOI：
10.1073/pnas.2304643121
发表日期：
2024-02-27
关键词：
摘要：
Generating strong rapid adhesion between hydrogels has the potential to advance the capabilities of modern medicine and surgery. Current hydrogel adhesion technologies rely primarily on liquid - based diffusion mechanisms and the formation of covalent bonds, requiring prolonged time to generate adhesion. Here, we present a simple and versatile strategy using dry chitosan polymer films to generate instant adhesion between hydrogel-hydrogel and hydrogel-elastomer surfaces. Using this approach we can achieve extremely high adhesive energies (>3,000 J/m(2)), which are governed by pH change and non- covalent interactions including H- bonding, Van der Waals forces, and bridging polymer entanglement. Potential examples of biomedical applications are presented, including local tissue cooling, vascular sealing, prevention of surgical adhesions, and prevention of hydrogel dehydration. We expect these findings and the simplicity of this approach to have broad implications for adhesion strategies and hydrogel design.