9期

最新文章

• Diverse roles of pontine NPS- expressing neurons in sleep regulation AI翻译
  作者：Xing, Lijuan; Zou, Xianlin; Yin, Chen; Webb, John M.; Shi, Guangsen; Ptacek, Louis J.; Fu, Ying- Hui
  作者单位：University of California System; University of California San Francisco; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Neuropeptide S (NPS) was postulated to be a wake- promoting neuropeptide with unknown mechanism, and a mutation in its receptor (NPSR1) causes the short sleep duration trait in humans. We investigated the role of different NPS+ nuclei in sleep/wake regulation. Loss- of- function and chemogenetic studies revealed that NPS+ neurons in the parabrachial nucleus (PB) are wake- promoting, whereas peri-locus coeruleus (peri-LC) NPS+ neurons are not important for sleep/wake modulation. Further, we fou...
• Evolutionary continuity and divergence of auditory dorsal and ventral pathways in primates revealed by ultra- high field diffusion MRI AI翻译
  作者：Zhang, Yang; Shen, Sherry Xinyi; Bibic, Adnan; Wang, Xiaoqin
  作者单位：Johns Hopkins University; Johns Hopkins University
  摘要：Auditory dorsal and ventral pathways in the human brain play important roles in supporting speech and language processing. However, the evolutionary root of the dual auditory pathways in the primate brain is unclear. By parcellating the auditory cortex of marmosets (a New World monkey species), macaques (an Old World monkey species), and humans using the same individual- based analysis method and tracking the pathways from the auditory cortex based on multi- shell diffusion- weighted MRI (dMRI...
• Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability AI翻译
  作者：Dutta, Debdeep; Kanca, Oguz; Shridharan, Rishi V.; Marcogliese, Paul C.; Steger, Benjamin; Morimoto, Marie; Frost, F. Graeme; Macnamara, Ellen; Wangler, Michael F.; Yamamoto, Shinya; Jenny, Andreas; Adams, David; Malicdan, May C.; Bellen, Hugo J.
  作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; University of Manitoba
  摘要：Nascent proteins destined for the cell membrane and the secretory pathway are targeted to the endoplasmic reticulum (ER) either posttranslationally or cotranslationally. The signal- independent pathway, containing the protein TMEM208, is one of three pathways that facilitates the translocation of nascent proteins into the ER. The in vivo function of this protein is ill characterized in multicellular organisms. Here, we generated a CRISPR- induced null allele of the fruit fly ortholog CG8320/Tm...
• Effective green treatment of sewage sludge from Fenton reactions: Utilizing MoS2 for sustainable resource recovery AI翻译
  作者：Liang, Zhiyan; Yan, Qingyun; Ou, Huase; Li, Dawei; Zhang, Yayun; Zhang, Jinlong; Zeng, Lixi; Xing, Mingyang
  作者单位：East China University of Science & Technology; East China University of Science & Technology; Jinan University; Nanjing University of Information Science & Technology; East China University of Science & Technology
  摘要：Effectively managing sewage sludge from Fenton reactions in an eco-friendly way is vital for Fenton technology's viability in pollution treatment. This study focuses on sewage sludge across various treatment stages, including generation, concentration, dehydration, and landfill, and employs chemical composite MoS2 to facilitate green resource utilization of all types of sludge. MoS2, with exposed Mo4+ and low-coordination sulfur, enhances iron cycling and creates an acidic microenvironment on ...
• OCA- B/Pou2af 1 is sufficient to promote CD4+T cell memory and prospectively identifies memory precursors AI翻译
  作者：Sun, Wenxiang; Hughes, Erik P.; Kim, Heejoo; Perovanovic, Jelena; Charley, Krystal R.; Perkins, Bryant; Du, Junhong; Ibarra, Andrea; Syage, Amber R.; Hale, J. Scott; Williams, Matthew A.; Tantin, Dean
  作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute
  摘要：The molecular mechanisms leading to the establishment of immunological memory are inadequately understood, limiting the development of effective vaccines and durable antitumor immune therapies. Here, we show that ectopic OCA- B expression is sufficient to improve antiviral memory recall responses, while having minimal effects on primary effector responses. At peak viral response, short- lived effector T cell populations are expanded but show increased Gadd45b and Socs2 expression, while memory...
• MXene- mediated reconfiguration induces robust nickel-iron catalysts for industrial- grade water oxidation AI翻译
  作者：Yu, Qian; Chen, Yuzhen; Liu, Jiao; Li, Cheng; Hu, Jingguo; Xu, Xiaoyong
  作者单位：Yangzhou University
  摘要：Nickel-iron oxy/hydroxides (NiFeOxHy) emerge as an attractive type of electrocatalysts for alkaline water oxidation reaction (WOR), but which encounter a huge challenge in stability, especially at industrial - grade large current density due to uncontrollable Fe leakage. Here, we tailor the Fe coordination by a MXene- mediated reconfiguration strategy for the resultant NiFeOxHy catalyst to alleviate Fe leakage and thus reinforce the WOR stability. The introduction of ultrafine MXene with surfa...
• Small- molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS- mutant cancers AI翻译
  作者：Jansen, Robin A.; Mainardi, Sara; Dias, Matheus Henrique; Bosma, Astrid; van Dijk, Emma; Selig, Roland; Albrecht, Wolfgang; Laufer, Stefan A.; Zender, Lars; Bernards, Rene
  作者单位：Netherlands Cancer Institute; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Helmholtz Association; German Cancer Research Center (DKFZ)
  摘要：The Kirsten rat sarcoma viral oncogene homologue KRAS is among the most commonly mutated oncogenes in human cancers, thus representing an attractive target for precision oncology. The approval for clinical use of the first selective inhibitors of G12C mutant KRAS therefore holds great promise for cancer treatment. However, despite initial encouraging clinical results, the overall survival benefit that patients experience following treatment with these inhibitors has been disappointing to date,...
• Sleep shapes the associative structure underlying pattern completion in multielement event memory AI翻译
  作者：Lutz, Nicolas D.; Martinez- Albert, Estefania; Friedrich, Hannah; Born, Jan; Besedovsky, Luciana
  作者单位：Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; University of Munich; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; German Center for Diabetes Research (DZD); Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health
  摘要：Sleep supports the consolidation of episodic memory. It is, however, a matter of ongoing debate how this effect is established, because, so far, it has been demonstrated almost exclusively for simple associations, which lack the complex associative structure of real - life events, typically comprising multiple elements with different association strengths. Because of this associative structure interlinking the individual elements, a partial cue (e.g., a single element) can recover an entire mu...
• Laser direct overall water splitting for H2 and H2O2 production AI翻译
  作者：Yan, Bo; Gu, Qunfang; Cao, Weiwei; Cai, Biao; Li, Yinwu; Zeng, Zhiping; Liu, Pu; Ke, Zhuofeng; Meng, Sheng; Ouyang, Gang; Yang, Guowei
  作者单位：Sun Yat Sen University; Chinese Academy of Sciences; Institute of Physics, CAS; Hunan Normal University
  摘要：Hydrogen (H2) and hydrogen peroxide (H2O2) play crucial roles as energy carriers and raw materials for industrial production. However, the current techniques for H2 and H2O2 production rely on complex catalysts and involve multiple intermediate steps. In this study, we present a straightforward, environmentally friendly, and highly efficient laser- induced conversion method for overall water splitting to simultaneously generate H2 and H2O2 at ambient conditions without any catalysts. The laser...
• Boosting exciton dissociation and charge transfer in CsPbBr3 QDs via ferrocene derivative ligation for CO2 photoreduction AI翻译
  作者：Du, Chenyu; Sheng, Jianping; Zhong, Fengyi; He, Ye; Liu, Huiyu; Sun, Yanjuan; Dong, Fan
  作者单位：University of Electronic Science & Technology of China; University of Electronic Science & Technology of China
  摘要：Photo- catalytic CO2 reduction with perovskite quantum dots (QDs) shows potential for solar energy storage, but it encounters challenges due to the intricate multi- electron photoreduction processes and thermodynamic and kinetic obstacles associated with them. This study aimed to improve photo- catalytic performance by addressing surface barriers and utilizing multiple- exciton generation in perovskite QDs. A facile surface engineering method was employed, involving the grafting of ferrocene c...