9期

最新文章

• Structure of mavacamten- free human cardiac thick filaments within the sarcomere by cryoelectron tomography AI翻译
  作者：Chen, Liang; Liu, Jun; Rastegarpouyani, Hosna; Janssen, Paul M. L.; Pinto, Jose R.; Taylor, Kenneth A.
  作者单位：State University System of Florida; Florida State University; Yale University; Yale University; State University System of Florida; Florida State University; University System of Ohio; Ohio State University; State University System of Florida; Florida State University
  摘要：Heart muscle has the unique property that it can never rest; all cardiomyocytes contract ducing the required force. Thick filaments contain additional nonmyosin proteins, myosin- binding protein C and titin, the latter being the protein that transmits applied tension to the thick filament. How these three proteins interact to control thick filament activation is poorly understood. Here, we show using 3- D image reconstruction of frozen- hydrated human cardiac muscle myofibrils lacking exogenou...
• Structural identification of a selectivity filter in CFTR AI翻译
  作者：Levring, Jesper; Chen, Jue
  作者单位：Rockefeller University; Howard Hughes Medical Institute; Rockefeller University
  摘要：The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that regulates transepithelial salt and fluid homeostasis. CFTR dysfunction leads to reduced chloride secretion into the mucosal lining of epithelial tissues, thereby causing the inherited disease cystic fibrosis. Although several structures of CFTR are available, our understanding of the ion- conduction pathway is incomplete. In particular, the route that connects the cytosolic vestibule with the extracellula...
• Ligand-induced incompatible curvatures control ultrathin nanoplatelet polymorphism and chirality AI翻译
  作者：Monego, Debora; Dutta, Sarit; Grossman, Doron; Krapez, Marion; Bauer, Pierre; Hubley, Austin; Mahler, Benoit; Widmer-Cooper, Asaph; Abecassis, Benjamin
  作者单位：University of Sydney; University of Sydney; Ecole Normale Superieure de Lyon (ENS de LYON); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1
  摘要：The ability of thin materials to shape-shift is a common occurrence that leads to dynamic pattern formation and function in natural and man-made structures. However, harnessing this concept to rationally design inorganic structures at the nanoscale has remained far from reach due to a lack of fundamental understanding of the essential physical components. Here, we show that the interaction between organic ligands and the nanocrystal surface is responsible for the full range of chiral shapes se...
• In-place molecular preservation of cellulose in 5,000-year-old archaeological textile (vol 117, pg 19670, 2020) AI翻译
  作者：Reynaud, Corentin; Thoury, Mathieu; Dazzi, Alexandre; Latour, Gael; Scheel, Mario; Li, Jiayi; Thomas, Ariane; Moulherat, Christophe; Didier, Aurore; Bertrand, Loic
• Instant welding of gels by dry chitosan interlayers AI翻译
  作者：Spencer, Nicholas D.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
• Lutetium texaphyrin: A photocatalyst that triggers pyroptosis via biomolecular photoredox catalysis AI翻译
  作者：Xu, Yunjie; Chau, Calvin, V; Lee, Jieun; Sedgwick, Adam C.; Yu, Le; Li, Mingle; Peng, Xiaojun; Kim, Jong Seung; Sessler, Jonathan L.
  作者单位：Korea University; University of Texas System; University of Texas Austin; Shenzhen University
  摘要：Photon- controlled pyroptosis activation (PhotoPyro) is a promising technique for cancer immunotherapy due to its noninvasive nature, precise control, and ease of operation. Here, we report that biomolecular photoredox catalysis in cells might be an important mechanism underlying PhotoPyro. Our findings reveal that the photocatalyst lutetium texaphyrin (MLu) facilitates rapid and direct photoredox oxidation of nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and ...
• Targeting nuclear receptor corepressors for reversible male contraception AI翻译
  作者：Hong, Suk - Hyun; Castro, Glenda; Wang, Dan; Nofsinger, Russell; Kane, Maureen; Folias, Alexandra; Atkins, Annette R.; Yu, Ruth T.; Napoli, Joseph L.; Sassone-Corsi, Paolo; de Rooij, Dirk G.; Liddle, Christopher; Downes, Michael; Evans, Ronald M.
  作者单位：Salk Institute; University of California System; University of California Berkeley; University of California System; University of California Irvine; Institut National de la Sante et de la Recherche Medicale (Inserm); Utrecht University; University of Sydney; Westmead Institute for Medical Research; University of Sydney; Bristol-Myers Squibb
  摘要：Despite numerous female contraceptive options, nearly half of all pregnancies are unintended. Family planning choices for men are currently limited to unreliable condoms and invasive vasectomies with questionable reversibility. Here, we report the development of an oral contraceptive approach based on transcriptional disruption of cyclical gene expression patterns during spermatogenesis. Spermatogenesis involves a continuous series of self- renewal and differentiation programs of spermatogonia...
• Mechanism and cellular function of direct membrane binding by the ESCRT and ERES- associated Ca2+- sensor ALG-2 AI翻译
  作者：Shukla, Sankalp; Chen, Wei; Rao, Shanlin; Yang, Serim; Ou, Chenxi; Larsen, Kevin P.; Hummer, Gerhard; Hanson, Phyllis I.; Hurley, James H.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Michigan System; University of Michigan; Max Planck Society; Goethe University Frankfurt; University of California System; University of California Berkeley
  摘要：Apoptosis linked Gene - 2 (ALG-2) is a multifunctional intracellular Ca2+ sensor and the archetypal member of the penta-EF hand protein family. ALG-2 functions in the repair of damage to both the plasma and lysosome membranes and in COPII- dependent budding at endoplasmic reticulum exit sites (ERES). In the presence of Ca2+, ALG-2 binds to ESCRT-I and ALIX in membrane repair and to SEC31A at ERES. ALG-2 also binds directly to acidic membranes in the presence of Ca2+ by a combination of electro...
• Cooling inflammation while potentiating immune checkpoint inhibition: Enhancing the benefit-risk ratio of immuno- oncology therapy AI翻译
  作者：Potter, David A.; Guo, Zhijun; Lei, Jianxun; Antonarakis, Emmanuel S.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
• A model for stimulation of enzyme activity by a competitive inhibitor based on the interaction of terazosin and phosphoglycerate kinase 1 AI翻译
  作者：Riley, Mitchell J.; Mitchell, Colleen C.; Ernst, Sarah E.; Taylor, Eric B.; Welsh, Michael J.
  作者单位：University of Iowa; University of Iowa; University of Iowa; Howard Hughes Medical Institute; University of Iowa
  摘要：The drug terazosin (TZ) binds to and can enhance the activity of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1) and can increase ATP levels. That finding prompted studies of TZ in Parkinson's disease (PD) in which decreased neuronal energy metabolism is a hallmark feature. TZ was neuroprotective in cell - based and animal PD models and in large epidemiological studies of humans. However, how TZ might increase PGK1 activity has remained a perplexing question because structural data reve...