Hemodynamic regulation allows stable growth of microvascular networks

• 成果类型: Article
• 署名作者: Qi, Yujia; Chang, Shyr-Shea; Wang, Yixuan; Chen, Cynthia; Baek, Kyung In; Hsiai, Tzung; Roper, Marcus
• 署名单位: University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of Genoa; University of Michigan System; University of Michigan; University System of Georgia; Georgia Institute of Technology; Emory University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-13983
• DOI: 10.1073/pnas.2310993121
• 发表日期: 2024-02-27
• 关键词: blood-vessel structure; red-cell distribution; shear-stress; structural adaptation; in-vivo; FLOW; zebrafish; endothelium; diameter; requires

摘要

How do vessels find optimal radii? Capillaries are known to adapt their radii to maintain the shear stress of blood flow at the vessel wall at a set point, yet models of adaptation purely based on average shear stress have not been able to produce complex loopy networks that resemble real microvascular systems. For narrow vessels where red blood cells travel in a single file, the shear stress on vessel endothelium peaks sharply when a red blood cell passes through. We show that stable shear -stress -based adaptation is possible if vessel shear stress set points are cued to the stress peaks. Model networks that respond to peak stresses alone can quantitatively reproduce the observed zebrafish trunk microcirculation, including its adaptive trajectory when hematocrit changes or parts of the network are amputated. Our work reveals the potential for mechanotransduction alone to generate stable hydraulically tuned microvascular networks.