The sleep-circadian interface: A window into mental disorders

• 成果类型: Article
• 署名作者: Meyer, Nicholas; Lok, Renske; Schmidt, Christina; Kyle, Simon D.; McClung, Colleen A.; Cajochen, Christian; Scheer, Frank A. J. L.; Jones, Matthew W.; Chellappa, Sarah L.
• 署名单位: University of London; University College London; University College London Hospitals NHS Foundation Trust; University of London; King's College London; Stanford University; University of Liege; University of Liege; University of Oxford; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Basel; University of Basel; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; University of Bristol; University of Southampton
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-13982
• DOI: 10.1073/pnas.2214756121
• 发表日期: 2024-02-27
• 关键词: psychiatric-disorders; rhythm disruption; bipolar disorders; mood disorders; young-people; phase; DEPRESSION; light; metaanalysis; insomnia

摘要

Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances can alleviate psychopathology. Conversely, psychiatric symptoms can reciprocally exacerbate poor sleep and disrupt clockcontrolled processes. Despite progress in elucidating underlying mechanisms, a cohesive approach that integrates the dynamic interactions between psychiatric disorder with both sleep and circadian processes is lacking. This review synthesizes recent evidence for sleep- circadian dysfunction as a transdiagnostic contributor to a range of psychiatric disorders, with an emphasis on biological mechanisms. We highlight observations from adolescent and young adults, who are at greatest risk of developing mental disorders, and for whom early detection and intervention promise the greatest benefit. In particular, we aim to a) integrate sleep and circadian factors implicated in the pathophysiology and treatment of mood, anxiety, and psychosis spectrum disorders, with a transdiagnostic perspective; b) highlight the need to reframe existing knowledge and adopt an integrated approach which recognizes the interaction between sleep and circadian factors; and c) identify important gaps and opportunities for further research.