9期

最新文章

• Multiscale embedded printing of engineered human tissue and organ equivalents AI翻译
  作者：Zhang, Cheng; Hua, Weijian; Mitchell, Kellen; Raymond, Lily; Delzendehrooy, Fatemeh; Wen, Lai; Do, Changwoo; Chen, Jihua; Yang, Ying; Linke, Gabe; Zhang, Zhengyi; Krishnan, Mena Asha; Kuss, Mitchell; Coulter, Ryan; Bandala, Erick; Liao, Yiliang; Duan, Bin; Zhao, Danyang; Chai, Guangrui; Jin, Yifei
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; Dalian University of Technology; Iowa State University; Nevada System of Higher Education (NSHE); University of Nevada Reno; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Center for Nanophase Materials Sciences; Nevada System of Higher Education (NSHE); University of Nevada Reno; Huazhong University of Science & Technology; University of Nebraska System; University of Nebraska Medical Center; China Medical University
  摘要：Creating tissue and organ equivalents with intricate architectures and multiscale functional feature sizes is the first step toward the reconstruction of transplantable human tissues and organs. Existing embedded ink writing approaches are limited by achievable feature sizes ranging from hundreds of microns to tens of millimeters, which hinders their ability to accurately duplicate structures found in various human tissues and organs. In this study, a multiscale embedded printing (MSEP) strate...
• Unraveling the impact of a glyco- immune checkpoint in bone metastasis AI翻译
  作者：Laubli, Heinz
  作者单位：University of Basel; University of Basel
• Women's subsistence strategies predict fertility across cultures, but context matters AI翻译
  作者：Page, Abigail E.; Ringen, Erik J.; Koster, Jeremy; Mulder, Monique Borgerhoff; Kramen, Karen; Shenk, Mary K.; Stieglitz, Jonathan; Starkweather, Kathrine; Ziker, John P.; Boyette, Adam H.; Colleran, Heidi; Moya, Cristina; Du, Juan; Mattison, Siobhan M.; Greaves, Russell; Sum, Chun-Yi; Liu, Ruizhe; Lew-Levy, Sheina; Ntamboudila, Francy Kiabiya; Prall, Sean; Towner, Mary C.; Blumenfield, Tami; Migliano, Andrea B.; Major-Smith, Daniel; Dyble, Mark; Salali, Gul Deniz; Chaudhary, Nikhil; Derkx, Inez E.; Ross, Cody T.; Scelza, Brooke A.; Gurven, Michael D.; Winterhalder, Bruce P.; Corteza, Carmen; Pacheco-Cobos, Luis; Schacht, Ryan; Macfarlan, Shane J.; Leonetti, Donna; French, Jennifer C.; Alam, Nurul; Zohora, Fatema Tuz; Kaplan, Hillard S.; Hooper, Paul L.; Sear, Rebecca
  作者单位：Brunel University; University of London; London School of Hygiene & Tropical Medicine; University of Zurich; University of Zurich; University of Zurich; Max Planck Society; University of California System; University of California Davis; Utah System of Higher Education; University of Utah; Universite de Toulouse; Universite Toulouse 1 Capitole; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Boise State University; Lanzhou University; University of New Mexico; University of New Mexico; Boston University; Durham University; University of Missouri System; University of Missouri Columbia; Oklahoma State University System; Oklahoma State University - Stillwater; University of Zurich; University of Bristol; University of Cambridge; University of London; University College London; University of California System; University of California Los Angeles; University of California System; University of California Santa Barbara; Universidad Veracruzana; University of North Carolina; East Carolina University; University of Washington; University of Liverpool; International Centre for Diarrhoeal Disease Research (ICDDR)
  摘要：While it is commonly assumed that farmers have higher, and foragers lower, fertility compared to populations practicing other forms of subsistence, robust supportive evidence is lacking. We tested whether subsistence activities-incorporating market integration-are associated with fertility in 10,250 women from 27 small- scale societies and found considerable variation in fertility. This variation did not align with group- level subsistence typologies. Societies labeled as farmers did not have ...
• Bloch oscillations, Landau-Zener transition, and topological phase evolution in an array of coupled pendula AI翻译
  作者：Neder, Izhar; Sirote-Katz, Chaviva; Geva, Meital; Lahini, Yoav; Ilan, Roni; Shokef, Yair
  作者单位：Tel Aviv University; Tel Aviv University; Tel Aviv University; Tel Aviv University; Tel Aviv University; Hiroshima University
  摘要：We experimentally and theoretically study the dynamics of a one-dimensional array of pendula with a mild spatial gradient in their self -frequency and where neighboring pendula are connected with weak and alternating coupling. We map their dynamics to the topological Su-Schrieffer-Heeger model of charged quantum particles on a lattice with alternating hopping rates in an external electric field. By directly tracking the dynamics of a wave -packet in the bulk of the lattice, we observe Bloch os...
• Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism AI翻译
  作者：Greisman, Jack B.; Dalton, Kevin M.; Brookner, Dennis E.; Klureza, Margaret A.; Sheehan, Candice J.; Henning, Robert W.; Russi, Silvia; Hekstra, Doeke R.; Kim, In-Sik
  作者单位：Harvard University; Harvard University; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Harvard University
  摘要：Enzymes catalyze biochemical reactions through precise positioning of substrates, cofactors, and amino acids to modulate the transition -state free energy. However, the role of conformational dynamics remains poorly understood due to poor experimental access. This shortcoming is evident with Escherichia coli dihydrofolate reductase (DHFR), a model system for the role of protein dynamics in catalysis, for which it is unknown how the enzyme regulates the different active site environments requir...
• The contribution of gene flow, selection, and genetic drift to five thousand years of human allele frequency change AI翻译
  作者：Simon, Alexis; Coop, Graham
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis
  摘要：Genomic time series from experimental evolution studies and ancient DNA datasets offer us a chance to directly observe the interplay of various evolutionary forces. We show how the genome-wide variance in allele frequency change between two time points can be decomposed into the contributions of gene flow, genetic drift, and linked selection. In closed populations, the contribution of linked selection is identifiable because it creates covariances between time intervals, and genetic drift does...
• Reply to Lukhtanov: Polytypic species: Old wine in a new bottle AI翻译
  作者：Dufresnes, Christophe; Poyarkov, Nikolay A.; Jablonski, Daniel
  作者单位：Nanjing Forestry University; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Museum National d'Histoire Naturelle (MNHN); Lomonosov Moscow State University; Comenius University Bratislava
• Inverse regulation of SOS1 and HKT1 protein localization and stability by SOS3/CBL4 in Arabidopsis thaliana AI翻译
  作者：Gamez-Arjona, Francisco; Park, Hee Jin; Garcia, Elena; Aman, Rashid; Villalta, Irene; Raddatz, Natalia; Carranco, Raul; Ali, Akhtar; Ali, Zahir; Zareen, Shah; De Luca, Anna; Leidi, Eduardo O.; Daniel-Mozo, Miguel; Xu, Zheng-Yi; Albert, Armando; Kim, Woe-Yeon; Pardo, Jose M.; Sanchez-Rodriguez, Clara; Yun, Dae-Jin; Quintero, Francisco J.
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC - Instituto de Bioquimica Vegetal y Fotosintesis (IBVF); University of Sevilla; Swiss Federal Institutes of Technology Domain; ETH Zurich; Konkuk University; Chonnam National University; King Abdullah University of Science & Technology; Universite de Tours; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC); Northeast Normal University - China; Gyeongsang National University; Universidad Politecnica de Madrid
  摘要：To control net sodium (Na+) uptake, Arabidopsis plants utilize the plasma membrane (PM) Na+/H+ antiporter SOS1 to achieve Na+ efflux at the root and Na+ loading into the xylem, and the channel - like HKT1;1 protein that mediates the reverse flux of Na+ unloading off the xylem. Together, these opposing transport systems govern the partition of Na+ within the plant yet they must be finely co- regulated to prevent a futile cycle of xylem loading and unloading. Here, we show that the Arabidopsis S...
• cAMP binding to closed pacemaker ion channels is cooperative AI翻译
  作者：Kuschke, Stefan; Thon, Susanne; Sattler, Christian; Schwabe, Tina; Benndorf, Klaus; Schmauder, Ralf
  作者单位：Friedrich Schiller University of Jena
  摘要：The cooperative action of the subunits in oligomeric receptors enables fine- tuning of receptor activation, as demonstrated for the regulation of voltage- activated HCN pacemaker ion channels by relating cAMP binding to channel activation in ensemble signals. HCN channels generate electric rhythmicity in specialized brain neurons and cardiomyocytes. There is conflicting evidence on whether binding cooperativity does exist independent of channel activation or not, as recently reported for deter...
• White Americans' preference for Black people in advertising has increased in the past 66 years: A meta-analysis AI翻译
  作者：Lenk, Julia Diana; Hartmann, Jochen; Sattler, Henrik
  作者单位：University of Hamburg; Technical University of Munich
  摘要：This study investigates Black and White consumers' preferences for Black versus White people in United States advertising contexts over 66 y, from 1956 until 2022, a time in which the United States has experienced significant ethno-racial diversification. Examining Black and White consumers' reactions to visual advertising over more than half a century offers a unique and dynamic view of interracial preferences. Mass advertising reaches an audience of billions and can shape people's attitudes ...