42期

最新文章

• High- throughput screening for small- molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease AI翻译
  作者：Williams, Darian; Glasstetter, Logan M.; Jong, Tiffany T.; Chen, Tiffany; Kapoor, Abhijeet; Zhu, Sha; Zhu, Yanping; Calvo, Raul; Gehrlein, Alexandra; Wong, Kimberly; Hogan, Andrew N.; Vocadlo, David J.; Jagasia, Ravi; Marugan, Juan J.; Sidransky, Ellen; Henderson, Mark J.; Chen, Yu
  作者单位：National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS); National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); Simon Fraser University; Simon Fraser University; Roche Holding
  摘要：Glucocerebrosidase (GCase) is implicated in both a rare, monogenic disorder (Gaucher disease, GD) and a common, multifactorial condition (Parkinson's disease, PD); hence, it is an urgent therapeutic target. To identify correctors of severe protein misfolding and trafficking obstruction manifested by the pathogenic L444P- variant of GCase, we developed a suite of quantitative, high- throughput, cell- based assays. First, we labeled GCase with a small proluminescent HiBiT peptide reporter tag, e...
• Joining forces to push past paradoxes: Combining quantitative genetics and genomics shows evolution hiding in plain sight AI翻译
  作者：Bonnet, Timothee
  作者单位：Centre National de la Recherche Scientifique (CNRS)
• Methionine-rich domains emerge as facilitators of copper recruitment in detoxification systems AI翻译
  作者：Contaldo, Umberto; Savant-Aira, Dylan; Vergnes, Alexandra; Becam, Jerome; Biaso, Frederic; Ilbert, Marianne; Aussel, Laurent; Ezraty, Benjamin; Lojou, Elisabeth; Mazurenko, Ievgen
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite
  摘要：Copper homeostasis mechanisms are critical for bacterial resistance to copper- induced stress. The Escherichia coli multicopper oxidase copper efflux oxidase (CueO) is part of the copper detoxification system in aerobic conditions. CueO contains a methionine-rich (Met- rich) domain believed to interact with copper, but its exact function and the importance of related copper- binding sites remain unclear. This study investigates these open questions by employing a multimodal and multiscale appr...
• Legal provisions on medical aid in dying encode moral intuition AI翻译
  作者：Hannikainen, Ivar R.; Suarez, Jorge; Espericueta, Luis; Menendez-Ferreras, Maite; Rodriguez, David
  作者单位：University of Granada; University of Basque Country
  摘要：In recent decades, many jurisdictions have moved toward legalizing euthanasia and aid in dying. Here, we draw on a comprehensive quantitative review of current laws on assisted dying, experimental survey evidence, and four decades of time- series data to explore the relationship between these legislative transitions and change in moral attitudes. Our analyses reveal that existing laws on medical aid in dying impose a common set of eligibility restrictions, based on the patient's age, decision-...
• Overlooked branch turnover creates a widespread bias in forest carbon accounting AI翻译
  作者：Lim, Hyungwoo; Medvigy, David; Maekelae, Annikki; Kim, Dohyoung; Albaugh, Timothy J.; Knier, Aubrey; Blasko, Robert; Campoe, Otavio C.; Deshar, Rashila; Franklin, Oskar; Henriksson, Nils; Littke, Kim; Lutter, Reimo; Maier, Christopher A.; Palmroth, Sari; Rosenvald, Katrin; Slesak, Robert A.; Tullus, Arvo; Oren, Ram
  作者单位：Swedish University of Agricultural Sciences; International Institute for Applied Systems Analysis (IIASA); University of Tartu; University of Notre Dame; University of Helsinki; State University of New York (SUNY) System; University at Buffalo, SUNY; Virginia Polytechnic Institute & State University; Duke University; Universidade Federal de Lavras; North Carolina State University; Tribhuvan University; University of Washington; University of Washington Seattle; Estonian University of Life Sciences; United States Department of Agriculture (USDA); United States Forest Service; United States Department of Agriculture (USDA); United States Forest Service; Duke University
  摘要：Most measurements and models of forest carbon cycling neglect the carbon flux associated with the turnover of branch biomass, a physiological process quantified for other organs (fine roots, leaves, and stems). Synthesizing data from boreal, temperate, and tropical forests (184,815 trees), we found that including branch turnover increased empirical estimates of aboveground wood production by 16% (equivalent to 1.9 Pg Cy-1 globally), of similar magnitude to the observed global forest carbon sin...
• The peptide hormone PjCLE1 stimulates haustorium formation in the parasitic plant Phtheirospermum japonicum AI翻译
  作者：Greifenhagen, Anne; Ruwe, Hannes; Zimmer, Victoria; Messerschmidt, Jana; Bhukya, Durga Prasad Naik; Kenea, Hawi Deressa; Schaller, Andreas; Spallek, Thomas
  作者单位：University Hohenheim; University of Gottingen
  摘要：Phtheirospermum japonicum is a hemiparasitic plant of the Orobanchaceae, the largest family of parasitic plants. It extracts water and nutrients from other plants through haustoria along its roots. Haustoriogenesis, the formation of haustoria, is initiated by host- derived haustorium- inducing factors (HIFs). The first step in haustoriogenesis is the development of parasitically inactive protohaustoria. Here, we report that an sufficient to induce protohaustorium formation. PjCLE1 hyperactivat...
• A receptor for dual ligands governs plant immunity and hormone response and is targeted by a nematode effector AI翻译
  作者：Huang, Li; Yuan, Yulin; Ramirez, Chloe; Zhao, Zhe; Chen, Letian; Griebel, Thomas; Kud, Joanna; Kuhl, Joseph C.; Caplan, Allan; Dandurand, Louise-Marie; Xiao, Fangming
  作者单位：University of Idaho; South China Agricultural University; Guangdong Laboratory for Lingnan Modern Agriculture; Free University of Berlin; University of Arkansas System; University of Arkansas Fayetteville; University of Idaho
  摘要：In this study, we show that the potato ( Solanum tuberosum) pattern recognition receptor (PRR) NEMATODE- INDUCED LEUCINE-RICH REPEAT (LRR)-RLK1 (StNILR1) functions as a dual receptor, recognizing both nematode- associated molecular pattern ascaroside #18 (Ascr18) and plant hormone brassinosteroid (BR) to activate two different physiological outputs: pattern- triggered immunity (PTI) and BR response. Ascr18/BR- StNILR1 signaling requires the coreceptor potato BRASSINOSTEROID INSENSITIVE 1- ASSO...
• Tipping the balance between fairness and efficiency through temporoparietal stimulation AI翻译
  作者：Soutschek, Alexander; Sahin, Tuerkay; Tobler, Philippe N.
  作者单位：University of Munich; University of Zurich
  摘要：Maximizing the welfare of society requires distributing goods between groups of people with different preferences. Such decisions are difficult because different moral principles impose irreconcilable solutions. For example, utilitarian efficiency (maximize overall outcome across individuals) may need trade- off against Rawlsian fairness norms (maximize the outcome for the worst- off individual). We identify a brain mechanism enabling decision- makers to solve such trade- offs between efficien...
• Four decades of Eukaryotic DNA replication: From yeast genetics to high- resolution cryo- EM structures of the replisome AI翻译
  作者：Tye, Bik-Kwoon
  作者单位：Cornell University
  摘要：I had my eyes set on DNA replication research when I took my first molecular biology course in graduate school. My election to the National Academy of Sciences came just when I was retiring from active research. It gives me an opportunity to reflect on my personal journey in eukaryotic DNA replication research, which started as a thought experiment and culminated in witnessing the determination of the cryoelectron microscopic structure of the yeast replisome in the act of transferring histone-...
• The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof- of- principle report AI翻译
  作者：Yamamoto, Erin A.; Bagley, Jacob H.; Geltzeiler, Mathew; Sanusi, Olabisi R.; Dogan, Aclan; Liu, Jesse J.; Piantino, Juan
  作者单位：Oregon Health & Science University; Oregon Health & Science University; Oregon Health & Science University
  摘要：The glymphatic pathway was described as a network of perivascular spaces (PVS) that facilitates the organized movement of cerebrospinal fluid (CSF) between the subarachnoid space and brain parenchyma ( 1 ). CSF mixes with interstitial fluid, promoting clearance of soluble by-products from the central nervous system. This is suspected to be impaired phatic studies in rodents showed CSF tracer flow through the subarachnoid space and from the subarachnoid space, providing early evidence for human...