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作者：Toulme, Estelle; Lazaro, Andrea Salazar; Trimbuch, Thorsten; Rizo, Josep; Rosenmund, Christian
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：The Ca2+ sensor synaptotagmin-1 (Syt1) triggers neurotransmitter release together with the neuronal sensitive factor attachment protein receptor (SNARE) complex formed by syntaxin-1, SNAP25, and synaptobrevin. Moreover, Syt1 increases synaptic vesicle (SV) priming and impairs spontaneous vesicle release. The Syt1 C2B domain binds to the SNARE complex through a primary interface via two regions (I and II), but how exactly this interface mediates distinct functions of Syt1 and the mechanism unde...
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作者：Burtt, David G.; Stern, Jennifer C.; Webster, Christopher R.; Hofmann, Amy E.; Franz, Heather B.; Sutter, Brad; Thorpe, Michael T.; Kite, Edwin S.; Eigenbrode, Jennifer L.; Pavlov, Alexander A.; House, Christopher H.; Tutolo, Benjamin M.; Marais, David J. Des; Rampe, Elizabeth B.; Mcadam, Amy C.; Malespin, Charles A.
作者单位：National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); National Aeronautics & Space Administration (NASA); University of Chicago; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Calgary; National Aeronautics & Space Administration (NASA); NASA Ames Research Center
摘要：Carbonate minerals are of particular interest in paleoenvironmental research as they are an integral part of the carbon and water cycles, both of which are relevant to habitability. Given that these cycles are less constrained on Mars than they are on Earth, the identification of carbonates has been a point of emphasis for rover missions. Here, we present carbon (delta 13C) and oxygen (delta 18O) isotope data from four carbonates encountered by the Curiosity rover within the Gale crater. The c...
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作者：Feinberg, Aryeh; Selin, Noelle E.; Braban, Christine F.; Chang, Kai- Lan; Custodio, Danilo; Jaffe, Daniel A.; Kyllonen, Katriina; Landis, Matthew S.; Leeson, Sarah R.; Luke, Winston; Molepo, Koketso M.; Murovec, Marijana; Mastromonaco, Michelle G. Nerentorp; Pfaffhuber, Katrine Aspmo; Ruediger, Julian; Sheu, Guey- Rong; St. Louis, Vincent L.
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); UK Centre for Ecology & Hydrology (UKCEH); University of Colorado System; University of Colorado Boulder; National Oceanic Atmospheric Admin (NOAA) - USA; Max Planck Society; University of Washington; University of Washington Bothell; University of Washington; University of Washington Seattle; Finnish Meteorological Institute; United States Environmental Protection Agency; National Oceanic Atmospheric Admin (NOAA) - USA; Helmholtz Association; Helmholtz-Zentrum Hereon; IVL Swedish Environmental Research Institute; NILU; National Central University; University of Alberta; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC)
摘要：Anthropogenic activities emit similar to 2,000 Mg y(-1) of the toxic pollutant mercury (Hg) into the atmosphere, leading to long- range transport and deposition to remote ecosystems. Global anthropogenic emission inventories report increases in Northern Hemispheric (NH) Hg emissions during the last three decades, in contradiction with the observed decline in atmospheric Hg concentrations at NH measurement stations. Many factors can obscure the link between anthropogenic emissions and atmospher...
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作者：Jones, Theresa M.; McNamara, Kathryn B.
作者单位：University of Melbourne
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作者：Kalinoski, Hannah; Daoud, Abdel; Rusinkevich, Vitali; Jurcova, Ivana; Talor, Monica V.; Welsh, Robin A.; Hughes, David; Zemanova, Katerina; Striz, Ilja; Hooper, Jody E.; Kautzner, Josef; Peichl, Petr; Melenovsky, Vojtech; Won, Taejoon; Cihakova, Daniela
作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University; Institute for Clinical & Experimental Medicine (IKEM); Johns Hopkins University; Institute for Clinical & Experimental Medicine (IKEM); Stanford University; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Cardiac myosin- specific (MyHC) T cells drive the disease pathogenesis of immune checkpoint inhibitor-associated myocarditis (ICI- myocarditis). To determine whether MyHC T cells are tissue- resident memory T (TRM) cells, we characterized cardiac T RM cells in naive mice and established that they have a distinct phenotypic and transcriptional profile that can be defined by their upregulation of CD69, PD- 1, and CXCR6. We then investigated the effects of cardiac injury through a modified experi...
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作者：Liu, Aijun; Liu, Yezhou; Masachs, Claudia Llinas del Torrent; Zhang, Weijia; Pardo, Leonardo; Ye, Richard D.
作者单位：The Chinese University of Hong Kong, Shenzhen; Guangdong Medical University; Autonomous University of Barcelona; The Chinese University of Hong Kong, Shenzhen
摘要：Kaposi's sarcoma- associated herpesvirus (KSHV) encodes a viral G protein- coupled receptor, KSHV-GPCR, that contributes to KSHV immune evasion and pathogenesis of Kaposi's sarcoma. KSHV-GPCR shares a high similarity with CXC chemokine receptors CXCR2 and can be activated by selected chemokine ligands. Like other herpesvirus- encoded GPCRs, KSHV-GPCR is characterized by its constitutive activity by coupling to various G proteins. We investigated the structural basis of ligand- dependent and co...
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作者：Alexander, Harriet
作者单位：Woods Hole Oceanographic Institution
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作者：Gu, Chao; Chen, Haiyan; Zhao, Yusheng; Wang, Shanmin
作者单位：Southern University of Science & Technology; State University of New York (SUNY) System; Stony Brook University; Eastern Institute of Technology, Ningbo
摘要：Strong steels are primarily fabricated by introducing spatial obstacles (e.g., stacking faults and precipitates) that inhibit dislocation slips under stress to achieve high strength. However, for most low- carbon steels, such obstacles are difficult to form mainly because the martensitic transition is kinetically unfavorable by conventional methods, which precludes the attainment of high- strength materials in these steels with low solute contents. Here, we report an innovative high- pressure ...
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作者：Princepe, Debora; de Aguiar, Marcus A. M.
作者单位：Universidade Estadual de Campinas; Abdus Salam International Centre for Theoretical Physics (ICTP)
摘要：Mitochondrial function relies on the coordinated expression of mitochondrial and nuclear genes, exhibiting remarkable resilience despite high mitochondrial mutation rates. The nuclear compensation mechanism suggests deleterious mitochondrial alleles drive compensatory nuclear mutations to preserve mito-nuclear compatibility. However, prevalence and factors conditioning this phenomenon remain debated due to its conflicting evidence. Here, we investigate how mito-nuclear incompatibilities impact...
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作者：Bassani, Francesca; Fatichi, Simone; Rinaldo, Andrea; Bonetti, Sara
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; National University of Singapore; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Padua
摘要：Allometric scaling relations are widely used to link biological processes to body size in nature. Several studies have shown that such scaling laws hold also for natural ecosystems, including individual trees and forests, riverine metabolism, and river network organization. However, the derivation of scaling laws for catchment-scale water and carbon fluxes has not been achieved so far. Here, we focus on scaling relations of catchment green metabolism, defined as the set of ecohydrological and ...
