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作者：Kreutzberger, Alex J. B.; Sanyal, Anwesha; Saminathan, Anand; Bloyet, Louis-Marie; Stumpf, Spencer; Liu, Zhuoming; Ojha, Ravi; Patjas, Markku T.; Geneid, Ahmed; Scanavachi, Gustavo; Doyle, Catherine A.; Somerville, Elliott; Correia, Ricardo Bango Da Cunha; Di Caprio, Giuseppe; Toppila-Salmi, Sanna; Makitie, Antti; Kiessling, Volker; Vapalahti, Olli; Whelan, Sean P. J.; Balistreri, Giuseppe; Kirchhausen, Tom
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作者：Shang, Luoran; Xu, Ke; Lu, Peter J.; Abbaspourrad, Alireza; Zhao, Yuanjin; Weitz, David A.
作者单位：Harvard University; Fudan University; Peking University; Harvard University; Cornell University; Southeast University - China; Nanjing University; Harvard University
摘要：Droplets of one fluid in a second, immiscible fluid are typically spherical in shape due to the interfacial tension between the two fluids. Shear forces can lead to droplet deformation when they are subjected to flow, and these effects can be further modified when the droplet is stabilized by a surfactant due to a flow- induced gradients in the surfactant concentration. An alternative method of stabilizing droplets is through the use of colloidal particles, whose stabilization behavior is intr...
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作者：Then, Li; Feng, Hongsong; Li, Fengling; Lei, Fengchun; Wu, Jie; Wei, Guo-Wei
作者单位：Michigan State University; Dalian University of Technology; Michigan State University; Michigan State University
摘要：In the past decade, topological data analysis has emerged as a powerful algebraic topology approach in data science. Although knot theory and related subjects are a focus of study in mathematics, their success in practical applications is quite limited due to the lack of localization and quantization. We address these challenges by introducing knot data analysis (KDA), a paradigm that incorporates curve segmentation and multiscale analysis into the Gauss link integral. The resulting multiscale...
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作者：Calvert, Jacob; Randall, Dana
作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology
摘要：The global steady state of a system in thermal equilibrium exponentially favors configurations with lesser energy. This principle is a powerful explanation of selforganization because energy is a local property of configurations. For nonequilibrium systems, there is no such property for which an analogous principle holds, hence no common explanation of the diverse forms of self-organization they exhibit. However, a flurry of recent empirical results has shown that a local property of configura...
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作者：Liu, Jia; Wang, Yang; Tian, Miaomiao; Xia, Mingjie; Zheng, Yi; Hao, Miao; Qian, Yuqiang; Shu, Hengyao; Zhang, Wenxia; Peng, Pinghui; Zhao, Zhexuan; Dong, Kejian; Peng, Wanting; Gao, Tian; Li, Zhanjun; Jin, Xin; Wei, Min; Feng, Yunpeng
作者单位：Northeast Normal University - China; Jilin University; Jilin University; Jilin University
摘要：Elevated lipid synthesis is one of the best-characterized metabolic alterations in cancer and crucial for membrane expansion. As a key rate-limiting enzyme in de novo fatty acid synthesis, ATP-citrate lyase (ACLY) is frequently up-regulated in tumors and regulated by posttranslational modifications (PTMs). Despite emerging evidence showing O-GlcNAcylation on ACLY, its biological function still remains unknown. Here, we observed a significant upregulation of ACLY O-GlcNAcylation in various type...
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作者：Gao, Jun; Yang, Jingyi; Dong, Hongzhe; Tao, Shaoyang; Shi, Jianbo; He, Bin; Bian, Xiqing; Wu, Jian-lin; Yin, Yongguang; Hu, Ligang; Jiang, Guibin
作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Macau University of Science & Technology; Jianghan University
摘要：Methylmercury (MeHg) is a bioaccumulating neurotoxin mainly produced by anaerobic microorganisms, with methanogen being one of the important methylators. A critical aspect for understanding the mechanism for microbial mercury (Hg) methylation is the origin of the methyl group. However, the origin of methyl group in methanogen- mediated Hg methylation remains unclear. This study aims to identify the source of methyl group for MeHg synthesis in methanogens. Our study revealed that Hg methylation...
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作者：Hu, Yingjie; Lopez, Victor A.; Xu, Hengyi; Pfister, James P.; Song, Bing; Servage, Kelly A.; Sakurai, Masahiro; Jones, Benjamin T.; Mendell, Joshua T.; Wang, Tao; Wu, Jun; Lambowitz, Alan M.; Tomchick, Diana R.; Pawlowski, Krzysztof; Tagliabracci, Vincent S.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：ATP- grasp superfamily enzymes contain a hand- like ATP- binding fold and catalyze a variety of reactions using a similar catalytic mechanism. More than 30 protein families are categorized in this superfamily, and they are involved in a plethora of cellular processes and human diseases. Here, we identify C12orf29 (RLIG1) as an atypical ATP- grasp enzyme that ligates RNA. Human RLIG1 and its homologs autoadenylate on an active site Lys residue as part of a reaction intermediate that specificall...
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作者：Bai, Jinyue; Jiang, Peiyong; Ji, Lu; Lam, W. K. Jacky; Zhou, Qing; Ma, Mary- Jane L.; Ding, Spencer C.; Ramakrishnan, Saravanan; Wan, Chun Wai; Yang, Tongxin Claire; Yukawa, Masashi; Chan, Rebecca W. Y.; Qiao, Rong; Yu, Stephanie C. Y.; Choy, L. Y. Lois; Shi, Yuwei; Wang, Zilong; Tam, Tommy H. C.; Law, Man Fai; Wong, Raymond S. M.; Wong, John; Chan, Stephen Lam; Wong, Grace L. H.; Wong, Vincent W. S.; Chan, K. C. Allen; Lo, Y. M. Dennis
作者单位：Chinese University of Hong Kong; Chinese University of Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong; Prince of Wales Hospital
摘要：The analysis of tissues of origin of cell- free DNA (cfDNA) is of research and diagnostic interest. Many studies focused on bisulfite treatment or immunoprecipitation protocols to assess the tissues of origin of cfDNA. DNA loss often occurs during such processes. Fragmentomics of cfDNA molecules has uncovered a wealth of information related to tissues of origin of cfDNA. There is still much room for the development of tools for assessing contributions from various tissues into plasma using fra...
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作者：Barbot, Sylvain
作者单位：University of Southern California
摘要：Constitutive models of fault friction form the basis of physics-based simulations of seismic activity. A generally accepted framework for the slip-rate and state dependence of friction involves a thermally activated process, whereby the probability of slip along microasperities adheres to an Arrhenius law. This model, which has become widely adopted among experimentalists and theoreticians, predicts a continuous increase of the direct effect with absolute temperature, but is it observed experi...
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作者：Derry, Louis A.
作者单位：Cornell University; Universite Paris Cite
摘要：Estimates of sedimentary organic carbon burial fluxes based on inventory and isotope mass balance methods have been divergent. A new calculation of the isotope mass balance using a revised assessment of the inputs to the ocean- atmosphere system resolves the apparent discrepancy. Inputs include weathering of carbonate and old kerogen, geogenic methane oxidation, and volcanic and metamorphic degassing. Volcanic and metamorphic degassing comprise approximate to 23% of the total C input. Inputs f...
