42期

最新文章

• Transcriptional repression by HDAC3 mediates T cell exclusion from Kras mutant lung tumors AI翻译
  作者：McGuire, Caroline K.; Meehan, Ambryn S.; Couser, Evan; Bull, Lois; Minor, Allegra C.; Hogan, Alexandra Kuhlmann -; Kaech, Susan M.; Shaw, Reuben J.; Eichner, Lillian J.
  作者单位：Northwestern University; Salk Institute; Salk Institute
  摘要：Histone Deacetylase 3 (HDAC3) function in vivo is nuanced and directed in a tissue- specific fashion. The importance of HDAC3 in Kras mutant lung tumors has recently been identified, but HDAC3 function in this context remains to be fully elucidated. Here, we identified HDAC3 as a lung tumor cell-intrinsic transcriptional regulator of the tumor immune microenvironment. In Kras mutant lung cancer cells, we found that HDAC3 is a direct transcriptional repressor of a cassette of secreted chemokine...
• The pace of change of summertime temperature extremes AI翻译
  作者：McKinnon, Karen A.; Simpson, Isla R.; Williams, A. Park
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Summer temperature extremes can have large impacts on humans and the biosphere, and an increase in heat extremes is one of the most visible symptoms of climate change. Multiple mechanisms have been proposed that would predict faster warming of heat extremes than typical summer days, but it is unclear whether this is occurring. Here, we show that, in both observations and historical climate model simulations, the hottest summer days have warmed at the same pace as the median globally, in each h...
• Structural origin of relaxation in dense colloidal suspensions AI翻译
  作者：Sahu, Ratimanasee; Sharma, Mohit; Schall, Peter; Bhattacharyya, Sarika Maitra; Chikkadi, Vijayakumar
  作者单位：Indian Institute of Science Education & Research (IISER) Pune; Council of Scientific & Industrial Research (CSIR) - India; CSIR - National Chemical Laboratory (NCL); Academy of Scientific & Innovative Research (AcSIR); University of Amsterdam
  摘要：Amorphous solids relax via slow molecular rearrangement induced by thermal fluctuations or applied stress. Microscopic structural signatures predicting these structural relaxations have been long searched for but have so far only been found in dynamic quantities such as vibrational quasi-localized soft modes or with structurally trained neural networks. A physically meaningful structural quantity remains elusive. Here, we introduce a structural order parameter derived from the mean-field cagin...
• Human tissue- resident NK cells in the lung have a higher glycolytic capacity than non- tissue- resident NK cells in the lung and blood AI翻译
  作者：Walsh, Aaron; Woods, Robbie; Batten, Isabella; Murphy, Dearbhla M.; Connolly, Sarah A.; Duffin, Emily; O'Gallchobhair, Oisin; Nadarajan, Parthiban; O'Connell, Finbarr; Gleeson, Laura E.; Keane, Joseph; Basdeo, Sharee A.
  作者单位：Trinity College Dublin; Trinity College Dublin
  摘要：Tissue- resident natural killer (trNK) cells are present in the human lung, yet their metabolic function is unknown. NK cell effector and metabolic function are intrinsically linked therefore targeting metabolism presents therapeutic potential in supporting NK cell effector function. This study identifies trNK cells in human bronchoalveolar lavage fluid (BALF) and reveals their distinct metabolic function. To assess the differential phenotype and metabolism of NK cells in the lung, human BALF,...
• Functional inversion of circadian regulator REV- ERBα leads to tumorigenic gene reprogramming AI翻译
  作者：Yang, Yatian; Zhang, Xiong; Cai, Demin; Zheng, Xingling; Zhao, Xuan; Zou, June X.; Zhang, Jin; Borowsky, Alexander D.; Dall'Era, Marc A.; Corey, Eva; Mitsiades, Nicholas; Kung, Hsing-Jien; Chen, Xinbin; Li, Jian Jian; Downes, Michael; Evans, Ronald M.; Chen, Hong-Wu
  作者单位：University of California System; University of California Davis; Salk Institute; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of Washington; University of Washington Seattle; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis
  摘要：Profound functional switch of key regulatory factors may play a major role in homeostasis and disease. Dysregulation of circadian rhythm (CR) is strongly implicated in cancer with mechanisms poorly understood. We report here that the function of REV-ERB alpha, a major CR regulator of the orphan nuclear receptor subfamily, is dramatically altered in tumors in both its genome binding and functional mode. Loss of CR is linked to a functional inversion of REV-ERB alpha from a repressor in control ...
• YTHDC2 serves a distinct late role in spermatocytes during germ cell differentiation AI翻译
  作者：Bailey, Alexis S.; Fuller, Margaret T.
  作者单位：Stanford University
  摘要：Posttranscriptional regulation of gene expression by RNA- binding proteins can enhance the speed and robustness of cell state transitions by controlling RNA stability, localization, or if, when, or where mRNAs are translated. The RNA helicase YTHDC2 is required to shut down components of the mitotic program to facilitate a proper switch from mitosis to meiosis in mouse germ cells. Here, we show that YTHDC2 has a second essential role in promoting meiotic progression in late spermatocytes. Indu...
• Observation of Brownian elastohydrodynamic forces acting on confined soft colloids AI翻译
  作者：Fares, Nicolas; Lavaud, Maxime; Zhang, Zaicheng; Jha, Aditya; Amarouchene, Yacine; Salez, Thomas
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite de Bordeaux; Beihang University
  摘要：Confined motions in complex environments are ubiquitous in microbiology. These situations invariably involve the intricate coupling between fluid flow, soft boundaries, surface forces, and fluctuations. In the present study, such a coupling is investigated using a method combining holographic microscopy and advanced statistical inference. Specifically, the Brownian motion of soft micrometric oil droplets near rigid walls is quantitatively analyzed. All the key statistical observables are recon...
• Limits on inferring T cell specificity from partial information AI翻译
  作者：Henderson, James; Nagano, Yuta; Milighetti, Martina; Tiffeau-Mayer, Andreas
  作者单位：University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London
  摘要：A key challenge in molecular biology is to decipher the mapping of protein sequence to function. To perform this mapping requires the identification of sequence features most informative about function. Here, we quantify the amount of information (in bits) that T cell receptor (TCR) sequence features provide about antigen specificity. We identify informative features by their degree of conservation among antigen-specific receptors relative to null expectations. We find that TCR specificity syn...
• Paraneoplastic renal dysfunction in fly cancer models driven by inflammatory activation of stem cells AI翻译
  作者：Kwok, Sze Hang; Liu, Yuejiang; Bilder, David; Kim, Jung
  作者单位：University of Hong Kong; University of California System; University of California Berkeley
  摘要：Tumors can induce systemic disturbances in distant organs, leading to physiological changes that enhance host morbidity. In Drosophila cancer models, tumors have been known for decades to cause hypervolemic bloating of the abdominal cavity. Here we use allograft and transgenic tumors to show that hosts display fluid retention associated with autonomously defective secretory capacity of fly renal tubules, which function analogous to those of the human kidney. Excretion from these organs is bloc...
• Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity AI翻译
  作者：Li, Chengbei; Kaur, Amanpreet; Pavlidaki, Alexia; Spenle, Caroline; Rajnpreht, Irena; Donnadieu, Emmanuel; Salome, Nathalie; Molitor, Anne; Carapito, Raphael; Wack, Fanny; Erne, William; Lefebvre, Olivier; Averous, Gerlinde; Mitrentsi, Ioanna; Loustau, Thomas; Orend, Gertraud
  作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; CHU Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); CHU Strasbourg; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg
  摘要：Tumor- targeted therapies have often been inefficient due to the lack of concomitant control over the tumor microenvironment. Using an immunocompetent autologous breast cancer model, we investigated a MAtrix REgulating MOtif (MAREMO)- mimicking peptide, which inhibits the protumorigenic extracellular matrix (ECM) molecule tenascin-C that activates several cancer hallmarks. In cultured cells, targeting the MAREMO blocks tenascin-C signaling involved in cell adhesion and immune- suppression by i...