The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof- of- principle report

• 成果类型: Article
• 署名作者: Yamamoto, Erin A.; Bagley, Jacob H.; Geltzeiler, Mathew; Sanusi, Olabisi R.; Dogan, Aclan; Liu, Jesse J.; Piantino, Juan
• 署名单位: Oregon Health & Science University; Oregon Health & Science University; Oregon Health & Science University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-9972
• DOI: 10.1073/pnas.2407246121
• 发表日期: 2024-10-15
• 关键词: brain; clearance; mri

摘要

The glymphatic pathway was described as a network of perivascular spaces (PVS) that facilitates the organized movement of cerebrospinal fluid (CSF) between the subarachnoid space and brain parenchyma ( 1 ). CSF mixes with interstitial fluid, promoting clearance of soluble by-products from the central nervous system. This is suspected to be impaired phatic studies in rodents showed CSF tracer flow through the subarachnoid space and from the subarachnoid space, providing early evidence for human glymphatic function demonstrating that intrathecal gadolinium-based contrast agents allow visualization of perivascular glymphatic flow in humans.