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• Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein (vol 105, pg 20309, 2008) AI翻译
  作者：Miao, Dengshun; Su, Hanyi; He, Bin; Gao, Jianjun; Xia, Qingwen; Zhu, Min; Gu, Zhen; Goltzman, David; Karaplis, Andrew C.
• Gut bacteria of lepidopteran herbivores facilitate digestion of plant toxins AI翻译
  作者：Zhang, Nan; Qian, Zhaoyi; He, Jintao; Shen, Xiaoqiang; Lei, Xiaoyu; Sun, Chao; Fan, Jie; Felton, Gary W.; Shao, Yongqi
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Lepidopterans commonly feed on plant material, being the most significant insect herbivores in nature. Despite plant resistance to herbivory, such as producing toxic secondary metabolites, herbivores have developed mechanisms encoded in their genomes to tolerate or detoxify plant defensive compounds. Recent studies also highlight the role of gut microbiota in mediating detoxification in herbivores; however, convincing evidence supporting the significant contribution of gut symbionts is rare in...
• Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant AI翻译
  作者：Carmody, Patrick J.; Roushar, Francis J.; Tedman, Austin; Wang, Wei; Herwig, Madeline; Kim, Minsoo; McDonald, Eli F.; Noguera, Karen; Wong-Roushar, Jennifer; Poirier, Jon-Luc; Zelt, Nathan B.; Pockrass, Ben T.; McKee, Andrew G.; Kuntz, Charles P.; Raju, S. Vamsee; Plate, Lars; Penn, Wesley D.; Schlebach, Jonathan P.
  作者单位：Indiana University System; Indiana University Bloomington; Purdue University System; Purdue University; University of Alabama System; University of Alabama Birmingham; Vanderbilt University; Vanderbilt University; Vanderbilt University
  摘要：The cotranslational misfolding of the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) plays a central role in the molecular basis of CF. The misfolding of the most common CF variant (OF508) remodels both the translational regulation and quality control of CFTR. Nevertheless, it is unclear how the misassembly of the nascent polypeptide may directly influence the activity of the translation machinery. In this work, we identify a structural motif within the CFTR transc...
• Jamaican fruit bats mount a stable and highly neutralizing antibody response after bat influenza virus infection AI翻译
  作者：Kessler, Susanne; Stegen, Philipp; Zhan, Shijun; Schwemmle, Martin; Reuther, Peter; Schountz, Tony; Ciminski, Kevin
  作者单位：University of Freiburg; University of Freiburg; Colorado State University System; Colorado State University Fort Collins
  摘要：Antibodies are an essential component of the antiviral response in many species, but to immunity, including neutralizing antibodies. Here, we report that infection of Jamaican fruit bats with the bat influenza A virus H18N11 elicits a rapid and stable humoral immune response with a strong neutralizing capacity, associated with no detectable viral shedding after repeat challenge infection. Thus, the neutralizing antibody response of bats might play an important role in the bat immunity.
• Innovations through crop switching happen on the diverse margins of US agriculture AI翻译
  作者：Kling, Matthew M.; Brittain, Christopher T.; Galford, Gillian L.; Waring, Timothy M.; Hebert-Dufresne, Laurent; Dube, Matthew P.; Sabzian, Hossein; Gotelli, Nicholas J.; McGill, Brian J.; Niles, Meredith T.
  作者单位：University of Vermont; University of Vermont; University of Vermont; University of Vermont; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono; University of Vermont; University of Vermont; University of Maine System; University of Maine Augusta; University of Maine System; University of Maine Orono
  摘要：Crop switching, in which farmers grow a crop that is novel to a given field, can help agricultural systems adapt to changing environmental, cultural, and market forces. Yet while regional crop production trends receive significant attention, relatively little is known about the local-scale crop switching that underlies these macrotrends. We characterized local crop-switching patterns across the United States using the US Department of Agriculture (USDA) Cropland Data Layer, an annual time seri...
• Using JADES NIRCam photometry to investigate the dependence of stellar mass inferences on the IMF in the early universe AI翻译
  作者：Woodrum, Charity; Rieke, Marcia; Ji, Zhiyuan; Baker, William M.; Bhatawdekar, Rachana; Bunker, Andrew J.; Charlot, Stephane; Curtis-Lake, Emma; Eisenstein, Daniel J.; Hainline, Kevin; Hausen, Ryan; Helton, Jakob M.; Hviding, Raphael E.; Johnson, Benjamin D.; Robertson, Brant; Sun, Fengwu; Tacchella, Sandro; Whitler, Lily; Williams, Christina C.; Willmer, Christopher N. A.
  作者单位：University of Arizona; University of Cambridge; University of Cambridge; European Space Agency; European Space Astronomy Center; University of Oxford; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Sorbonne Universite; University of Hertfordshire; Smithsonian Institution; Johns Hopkins University; Max Planck Society; University of California System; University of California Santa Cruz
  摘要：The detection of numerous and relatively bright galaxies at redshifts z > 9 has prompted new investigations into the star-forming properties of high-redshift galaxies. Using local forms of the initial mass function (IMF) to estimate stellar masses of these galaxies from their light output leads to galaxy masses that are at the limit allowed for explore how varying the IMF assumed in studies of galaxies in the early universe changes the inferred values for the stellar masses of these galaxies. ...
• Natural variation in age- related dopamine neuron degeneration is glutathione dependent and linked to life span AI翻译
  作者：Coleman, Colin R.; Pallos, Judit; Bustos, Alicia Arreola -; Wang, Lu; Raftery, Daniel; Promislow, Daniel E. L.; Martin, Ian
  作者单位：Oregon Health & Science University; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; United States Department of Agriculture (USDA); Tufts University
  摘要：Aging is the biggest risk factor for Parkinson's disease (PD), suggesting that age- related changes in the brain promote dopamine neuron vulnerability. It is unclear, however, whether aging alone is sufficient to cause significant dopamine neuron loss, and if so, how this intersects with PD- related neurodegeneration. Here, through examining a large collection of naturally varying Drosophila strains, we find a strong relationship between life span and age- related dopamine neuron loss. Strains...
• Chlorophyll to zeaxanthin energy transfer in nonphotochemical quenching: An exciton annihilation- free transient absorption study AI翻译
  作者：Lee, Tsung- Yen; Lam, Lam; Patel-Tupper, Dhruv; Roy, Partha Pratim; Ma, Sophia A.; Lam, Henry E.; DeMott, Aviva Lucas-; Karavolias, Nicholas G.; Iwai, Masakazu; Niyogi, Krishna K.; Fleming, Graham R.
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley
  摘要：Zeaxanthin (Zea) is a key component in the energy- dependent, rapidly reversible, non- photochemical quenching process (qE) that regulates photosynthetic light harvesting. Previous transient absorption (TA) studies suggested that Zea can participate in direct quenching via chlorophyll (Chl) to Zea energy transfer. However, the contamination of intrinsic exciton-exciton annihilation (EEA) makes the assignment of TA signal ambiguous. In this study, we present EEA-free TA data using Nicotiana ben...
• Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory AI翻译
  作者：Mitchell, Sharon E.; Simpson, Megan; Coulet, Lena; Gouedard, Solenn; Hambly, Catherine; Morimoto, Juliano; Allison, David B.; Speakman, John R.
  作者单位：University of Aberdeen; Institut Agro; University of Aberdeen; Universidade Federal do Parana; Indiana University System; Indiana University Bloomington; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; China Medical University
  摘要：The disposable soma theory (DST) posits that organisms age and die because of a direct trade- off in resource allocation between reproduction and somatic maintenance. DST predicts that investments in reproduction accentuate somatic damage which increase senescence and shortens lifespan. Here, we directly tested DST predictions in breeding and nonbreeding female C57BL/6J mice. We measured reproductive outputs, body composition, daily energy expenditure, and oxidative stress at peak lactation an...
• SHARK enables sensitive detection of evolutionary homologs and functional analogs in unalignable and disordered sequences AI翻译
  作者：Chow, Chi Fung Willis; Ghosh, Soumyadeep; Hadarovich, Anna; Petroczy, Agnes Toth -
  作者单位：Max Planck Society; Technische Universitat Dresden
  摘要：Intrinsically disordered regions (IDRs) are structurally flexible protein segments with regulatory functions in multiple contexts, such as in the assembly of biomolecular condensates. Since IDRs undergo more rapid evolution than ordered regions, identifying homology of such poorly conserved regions remains challenging for state-of-the-art alignment-based methods that rely on position-specific conservation of residues. Thus, systematic functional annotation and evolutionary analysis of IDRs hav...