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作者：Pink, Katharina E.; Fischer, Barbara; Huffman, Michael A.; Miyabe-Nishiwaki, Takako; Hashimoto, Naoko Suda-; Kaneko, Akihisa; Wallner, Bernard; Pflueger, Lena S.
作者单位：Medical University of Vienna; University of Vienna; University of Vienna; Kyoto University; Kyoto University; University of Vienna
摘要：Human fetuses at term are large relative to the dimensions of the maternal birth canal, implying that their birth can be associated with difficulties. The tight passage through the human birth canal can lead to devastating outcomes if birth becomes obstructed, including maternal and fetal death. Although macaques have to accommodate similarly large fetuses, relative to their maternal birth canals, it was not known whether macaque mothers face birth difficulties similar to humans. Based on 27 y...
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作者：Baldassarri, Ilaria; Tavakol, Daniel Naveed; Graney, Pamela L.; Chramiec, Alan G.; Hibshoosh, Hanina; Vunjak-Novakovic, Gordana
作者单位：Columbia University; Columbia University; Columbia University; Columbia University; Columbia University
摘要：Incomplete understanding of metastatic disease mechanisms continues to hinder effective treatment of cancer. Despite remarkable advancements toward the identification of druggable targets, treatment options for patients in remission following primary tumor resection remain limited. Bioengineered human tissue models of metastatic capable of recreating the physiologically relevant milieu of metastatic colonization strengthen our grasp of cancer progression and contribute to the development of ef...
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作者：Gerbi, Susan A.; Spradling, Allan C.
作者单位：Brown University; Carnegie Institution for Science; Howard Hughes Medical Institute; Carnegie Institution for Science
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作者：Varnum, Michael E. W.; Baumard, Nicolas; Atari, Mohammad; Gray, Kurt
作者单位：Arizona State University; Arizona State University-Tempe; Universite PSL; Ecole Normale Superieure (ENS); University of Massachusetts System; University of Massachusetts Amherst; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
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作者：Xu, Liang
作者单位：Zhejiang University of Technology; Zhejiang University
摘要：Understanding the historical perception and value of teacher personalities reveals key educational priorities and societal expectations. This study analyzes the evolution of teachers' ascribed Big Five personality traits from 1800 to 2019, drawing on millions of English- language books. Word frequency analysis reveals that conscientiousness is the most frequently discussed trait, followed by agreeableness, openness, extraversion, and neuroticism. This pattern underscores society's focus on whe...
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作者：Buss, Eric W.; Lofaro, Olivia M.; Barnett, Anastasia; Leroy, Felix; Santoro, Bina; Siegelbaum, Steven A.; Bock, Tobias
作者单位：Columbia University; Columbia University; RWTH Aachen University
摘要：Hyperpolarization- activated, cyclic nucleotide-gated (HCN) channels generate the cationic Ih current in neurons and regulate the excitability of neuronal networks. The function of HCN channels depends, in part, on their subcellular localization. Of the four HCN isoforms (HCN1-4), HCN1 is strongly expressed in the dendrites of pyramidal neurons (PNs) in hippocampal area CA1 but also in presynaptic terminals of parvalbumin- positive interneurons (PV+ INs), which provide strong inhibitory contro...
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作者：Liu, Wenjie; Yao, Yushi; Meng, Jia; Qian, Shuhao; Han, Yubing; Zhou, Lingxi; Wang, Tao; Chen, Youhua; Chen, Lingmei; Ye, Zitong; Xu, Liang; Zhang, Meng; Qiu, Jianrong; Han, Tao; Liu, Xu; Kuang, Cuifang; Ding, Zhihua; Liu, Zhiyi
作者单位：Zhejiang University; Zhejiang University; University of Oxford; Zhejiang University; Huazhong University of Science & Technology
摘要：Cytoskeleton remodeling which generates force and orchestrates signaling and trafficking to govern cell migration remains poorly understood, partly due to a lack of an investigation tool with high system flexibility, spatiotemporal resolution, and computational sensitivity. Herein, we developed a multimodal superresolution imaging system-based architecture- driven quantitative (ADQ) framework in spatiotemporal- angular hyperspace to enable both identification of the optimal imaging mode with w...
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作者：Rycroft, Julian Anthony; Giorgio, Rachel Teresa; Sargen, Molly; Helaine, Sophie
作者单位：Harvard University; Harvard Medical School
摘要：The rise of antimicrobial failure is a global emergency, and causes beyond typical genetic resistance must be determined. One probable factor is the existence of sub- populations of transiently growth- arrested bacteria, persisters, that endure antibiotic treatment despite genetic susceptibility to the drug. The presence of persisters in infected hosts has been successfully established, notably through the development of fluorescent reporters. It is proposed that infection relapse is caused by...
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作者：Shaw, Alisa E.; Mihelich, Mattias N.; Whitted, Jackson E.; Reitman, Hannah J.; Timmerman, Adam J.; Tehseen, Muhammad; Hamdan, Samir M.; Schauer, Grant D.
作者单位：Colorado State University System; Colorado State University Fort Collins; King Abdullah University of Science & Technology
摘要：Replication stress describes endogenous and exogenous challenges to DNA replication in the S- phase. Stress during this critical process causes helicase-polymerase decoupling at replication forks, triggering the S- phase checkpoint, which orchestrates global replication fork stalling and delayed entry into G2. The replication stressor most often used to induce the checkpoint response in yeast is hydroxyurea (HU), a clinically used chemotherapeutic. The primary mechanism of S- phase checkpoint ...
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作者：Hadjiosif, Alkis M.; Gibo, Tricia L.; Smith, Maurice A.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Philips; Philips Healthcare; Johns Hopkins University; Harvard University
摘要：The cerebellum is critical for sensorimotor learning. The specific contribution that it makes, however, remains unclear. Inspired by the classic finding that for declarative memories, medial temporal lobe (MTL) structures provide a gateway to the formation of long- term memory but are not required for short- term memory, we hypothesized that for sensorimotor memories, the cerebellum may play an analogous role. Here, we studied the sensorimotor learning of individuals with severe ataxia from ce...
