45期

最新文章

• The reconstruction of evolutionary dynamics of processed pseudogenes indicates deep silencing of retrobiome in naked mole rat AI翻译
  作者：Kogan, Valeria; Molodtsov, Ivan; Fleyshman, Daria I.; V. Leontieva, Olga; Koman, Igor E.; V. Gudkov, Andrei
  作者单位：Ariel University; Roswell Park Comprehensive Cancer Center
  摘要：Approximately half of mammalian genomes are occupied by retrotransposons, highly repetitive interspersed genetic elements expanded through the mechanism of reverse transcription. The evolution of this retrobiome involved a series of explosive amplifications, presumably associated with high mutation rates, interspersed with periods of silencing. A by- product of retrotransposon activity is the formation of processed pseuWe examined the proportion of PPGs with varying degrees of deviation from t...
• A noncanonical GTPase signaling mechanism controls exit from mitosis in budding yeast AI翻译
  作者：Zhou, Xiaoxue; Weng, Shannon Y.; Bell, Stephen P.; Amon, Angelika
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; New York University
  摘要：In the budding yeast Saccharomyces cerevisiae, exit from mitosis is coupled to spindle position to ensure successful genome partitioning between mother and daughter cells. This coupling occurs through a GTPase signaling cascade known as the mitotic exit network (MEN). The MEN senses spindle position via a Ras- like GTPase Tem1 which localizes to the spindle pole bodies (SPBs, yeast equivalent of centrosomes) during anaphase and signals to its effector protein kinase Cdc15. How Tem1 couples the...
• Role of molecular damage in crack initiation mechanisms of tough elastomers AI翻译
  作者：Ju, Jianzhu; Sanoja, Gabriel E.; Cipelletti, Luca; Ciccotti, Matteo; Zhu, Bangguo; Narita, Tetsuharu; Hui, Chung Yuen; Creton, Costantino
  作者单位：Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); University of Texas System; University of Texas Austin; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Institut Universitaire de France; Cornell University
  摘要：Tough soft materials such as multiple network elastomers (MNE) or filled elastomers are typically stretchable and include significant energy dissipation mechanisms that prevent or delay crack growth. Yet most studies and fracture models focus on steady- state propagation and damage is assumed to be decoupled from the local stress and strain fields near the crack tip. We report an in situ spatial- temporally resolved 3D measurement of molecular damage in mechanophore-labeled MNE just before a c...
• The periaxonal space as a conduit for cerebrospinal fluid flow to peripheral organs AI翻译
  作者：Li, Xinyu; Wang, Siman; Zhang, Dianjun; Feng, Yuliang; Liu, Yingyu; Yu, Weiyang; Cui, Lulu; Harkany, Tibor; Verkhratsky, Alexei; Xia, Maosheng; Li, Baoman
  作者单位：China Medical University; China Medical University; China Medical University; Medical University of Vienna; Karolinska Institutet; University of Manchester; University of Basque Country; State Research Institute Centre for Innovative Medicine; China Medical University
  摘要：Mechanisms controlling the movement of the cerebrospinal fluid (CSF) toward peripheral nerves are poorly characterized. We found that, in addition to the foramina Magendie outflow could also occur along periaxonal spaces (termed PAS pathway) from the spinal cord to peripheral organs, such as the liver and pancreas. When interrogating the latter route, we found that serotonin, acting through 5- HT2B receptors expressed erization of F- actin, a cytoskeletal protein, to reduce the volume of epend...
• The persistent DDT footprint of ocean disposal, and ecological controls on bioaccumulation in fishes AI翻译
  作者：McGill, Lillian; Sleugh, Toni; Petrik, Colleen; Schiff, Kenneth; McLaughlin, Karen; Aluwihare, Lihini; Semmens, Brice
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; University of California System; University of California San Diego; Scripps Institution of Oceanography; Southern California Coastal Water Research Project; University of California System; University of California San Diego; Scripps Institution of Oceanography
  摘要：Globally, ocean dumping of chemical waste is a common method of disposal and relies on the assumption that dilution, diffusion, and dispersion at ocean scales will mitigate human exposure and ecosystem impacts. In southern California, extensive dumping of agrochemical waste, particularly chlorinated hydrocarbon contaminants such as DDT, via sewage outfalls and permitted offshore barging occurred for most of the last century. This study compiled a database of existing sediment and fish DDT meas...
• Cell binding tropism of rat hepatitis E virus is a pivotal determinant of its zoonotic transmission to humans AI翻译
  作者：Guo, Hongbo; Xu, Jiaqi; Situ, Jianwen; Li, Chunyang; Wang, Xia; Hou, Yao; Yang, Guangde; Wang, Lingli; Ying, Dong; Li, Zheng; Wang, Zijie; Su, Jia; Ding, Yibo; Zeng, Dou; Zhang, Jikai; Ding, Xiaohui; Wu, Shusheng; Miao, Weiwei; Tang, Renxian; Lu, Yihan; Kong, Huihui; Zhou, Peng; Zheng, Zizheng; Zheng, Kuiyang; Pan, Xiucheng; Sridhar, Siddharth; Wang, Wehshi
  作者单位：Xuzhou Medical University; University of Hong Kong; Xuzhou Medical University; Xiamen University; Chinese Academy of Sciences; Wuhan Institute of Virology, CAS; Guangzhou Laboratory; Fudan University; Chinese Academy of Agricultural Sciences; Harbin Veterinary Research Institute, CAAS
  摘要：Classically, all hepatitis E virus (HEV) variants causing human infection belong to the genus Paslahepevirus (HEV- A). However, the increasing cases of rat HEV infection in humans since 2018 challenged this dogma, posing increasing health threats. Herein, we investigated the underlying mechanisms dictating the zoonotic potentials of different HEV species and their possible cross- protection relationships. rat HEV particles penetrated the cell membrane and entered human target cells postbinding...
• Metabolic engineering of Corynebacterium glutamicum for the production of pyrone and pyridine dicarboxylic acids AI翻译
  作者：Cho, Jae Sung; Luo, Zi Wei; Moon, Cheon Woo; Prabowo, Cindy Pricilia Surya; Lee, Sang Yup
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
  摘要：Environmental concerns from plastic waste are driving interest in alternative monomers from bio- based sources. Pseudoaromatic dicarboxylic acids are promising alternatives with chemical structures similar to widely used petroleum- based aromatic dicarboxylic acids. However, their use in polyester synthesis has been limited due to production challenges. Here, we report the fermentative production of five pseudoaromatic dicarboxylic acids, including 2- pyrone- 4,6- dicarboxylic acid (PDC) and p...
• Designing multicomponent hydrides with potential high Tc superconductivity AI翻译
  作者：Denchfield, Adam; Park, Hyowon; Hemley, Russell J.
  作者单位：University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; United States Department of Energy (DOE); Argonne National Laboratory; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
  摘要：While hydrogen-rich materials have been demonstrated to exhibit high Tc superconductivity at high pressures, there is an ongoing search for ternary, quaternary, and more chemically complex hydrides that achieve such high critical temperatures at much lower pressures. First-principles searches are impeded by the computational complexity of solving the Eliashberg equations for large, complex crystal structures. Here, we adopt a simplified approach using electronic indicators previously establish...
• A mechanistic model of gossip, reputations, and cooperation (vol 121, e2400689121, 2024) AI翻译
  作者：Kawakatsu, Mari; Kessinger, Taylor A.; Plotkin, Joshua B.
• Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal women AI翻译
  作者：Ulrich, Nicole D.; Vargo, Alex; Ma, Qianyi; Shen, Yu - chi; Bazzano, Dominic; Hannum, D. Ford; Gurczynski, Stephen J.; Moore, Bethany B.; Schon, Samantha; Lieberman, Richard; Shikanov, Ariella; Marsh, Erica E.; Fazleabas, Asgerally; Li, Jun Z.; Hammoud, Saher Sue
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Michigan State University; University of Michigan System; University of Michigan
  摘要：The human uterus is a complex and dynamic organ whose lining grows, remodels, and regenerates every menstrual cycle or upon tissue damage. Here, we applied single- cell RNA sequencing to profile more the 50,000 uterine cells from both the endometrium and myometrium of five healthy premenopausal individuals, and jointly analyzed the data with a previously published dataset from 15 subjects. The resulting normal uterus cell atlas contains more than 167K cells, representing the lymphatic endothel...