45期

最新文章

• Reply to Rosenblum et al. and Carriquiry and Ommen: Understanding probative value, triers- of- fact, and usefulness of validity study results AI翻译
  作者：Guyll, Max; Madon, Stephanie; Yang, Yueran; Burd, Kayla A.; Wells, Gary
  作者单位：Arizona State University; Nevada System of Higher Education (NSHE); University of Nevada Reno; University of Wyoming; Iowa State University
• High functional vulnerability across the world's deep- sea hydrothermal vent communities AI翻译
  作者：Lucas, Joan M. Alfaro-; Chapman, Abbie S. A.; Tunnicliffe, Verena; Bates, Amanda E.
  作者单位：University of Victoria; University of London; University College London; University of Victoria
  摘要：At the nearly pristine hydrothermal vents of the deep sea, highly endemic animals depend upon bacteria nourished by hydrothermal fluids that emerge as outflows from the seafloor. These animals are remarkable in tolerating extreme conditions, including high heat, toxic reduced sulfide, and low oxygen. Here, we test whether the extreme vent environment has selected for functionally similar species across the world's deep ocean, despite well- established global geographic patterns of high phyloge...
• Artificial selection of two antagonistic E3 ubiquitin ligases finetunes soybean photoperiod adaptation and grain yield AI翻译
  作者：Wang, Fan; Liu, Shuangrong; Li, Haiyang; Fang, Chao; Fang, Sijia; Wang, Jianhao; Li, Shichen; Liu, Huan; Du, Haiping; Wang, Lingshuang; Pei, Xinxin; Su, Bohong; Sun, Zhihui; Li, Quan; Dong, Lidong; Cheng, Qun; Zhao, Xiaohui; Liu, Baohui; Lu, Sijia; Kong, Fanjiang; Lin, Xiaoya
  作者单位：Guangzhou University; Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS
  摘要：The precise control of flowering time is of utmost importance for crop adaptation to varying environmental conditions and consequently determines grain yield and plant fitness. Soybean E2 , the homolog of Arabidopsis GIGANTEA, is a major locus contributing to high- latitude adaptation and is involved in photoperiod sensitivity. However, due to major effects of E2 , additional genetic loci controlling soybean flowering and adaptation have historically been masked and difficult to identify. Here...
• Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling AI翻译
  作者：Duan, Weicheng; Huang, Guiyang; Sui, Yang; Wang, Kang; Yu, Yuxin; Chu, Xufeng; Cao, Xu; Chen, Liangpei; Liu, Jiahui; Eichler, Evan E.; Xiong, Bo
  作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; University of Washington; University of Washington Seattle; Nanjing Medical University; Huazhong University of Science & Technology; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Huazhong University of Science & Technology
  摘要：The molecular mechanisms underlying the neurodevelopmental disorders (NDDs) caused by DDX3X variants remain poorly understood. In this study, we validated that de novo DDX3X variants are enriched in female developmental delay (DD) patients and mainly affect the evolutionarily conserved amino acids based on a meta- analysis of 46,612 NDD trios. We generated a ddx3x deficient zebrafish allele, which exhibited reduced survival rate, DD, microcephaly, adaptation defects, anxiolytic behaviors, soci...
• Structural duality enables a single protein to act as a toxin-antidote pair for meiotic drive AI翻译
  作者：Hua, Yu; Zhang, Jianxiu; Yang, Man- Yun; Ren, Jing- Yi; Suo, Fang; Liang, Lingfei; Dong, Meng- Qiu; Ye, Keqiong; Du, Li - Lin
  作者单位：National Institute of Biological Sciences, Beijing; Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Tsinghua University
  摘要：In sexual reproduction, selfish genetic elements known as killer meiotic drivers (KMDs) bias inheritance by eliminating gametes that do not carry them. The selective killing behavior of most KMDs can be explained by a toxin-antidote model, where a toxin harms all gametes while an antidote provides resistance to the toxin in carriers. This study investigates whether and how the KMD element tdk1 in the fission yeast Schizosaccharomyces pombe deploys this strategy. Intriguingly, tdk1 relies on a ...
• Glycine synthesis from nitrate and glyoxylate mediated by ferroan brucite: An integrated pathway for prebiotic amine synthesis AI翻译
  作者：Chimiak, L.; Hara, E.; Sessions, A.; Templeton, A. S.
  作者单位：University of Colorado System; University of Colorado Boulder; California Institute of Technology
  摘要：Amino acids are present in all known life, so identifying the environmental conditions under which they can be synthesized constrains where life on Earth might have formed and where life might be found on other planetary bodies. All known abiotic amino acid syntheses require ammonia, which is only produced in reducing and neutral atmospheres. Here, we demonstrate that the Fe- bearing hydroxide mineral ferroan brucite [Fe0.33,Mg0.67(OH)2] can mediate the reaction of nitrate and glyoxylate to fo...
• Seawater alkalization via an energy-efficient electrochemical process for CO2 capture AI翻译
  作者：Guan, Xun; Zhang, Ge; Li, Jinlei; Kim, Sang Cheol; Feng, Guangxia; Li, Yuqi; Cui, Tony; Brest, Adam; Cui, Yi
  作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University
  摘要：Electrochemical pH-swing strategies offer a promising avenue for cost-effective and energy-efficient carbon dioxide (CO2) capture, surpassing the traditional thermally activated processes and humidity-sensitive techniques. The concept of elevating seawater's alkalinity for scalable CO2 capture without introducing additional chemical as reactant is particularly intriguing due to its minimal environmental impact. However, current commercial plants like chlor-alkali process or water electrolysis ...
• A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring AI翻译
  作者：Hua, Yu; Zhang, Jianxiu; Yang, Man-Yun; Zhang, Fan-Yi; Ren, Jing-Yi; Lyu, Xiao-Hui; Ding, Yan; Suo, Fang; Shao, Guang-Can; Li, Jun; Dong, Meng-Qiu; Ye, Keqiong; Du, Li-Lin
  作者单位：National Institute of Biological Sciences, Beijing; Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Tsinghua University
  摘要：Killer meiotic drivers (KMDs) are selfish genetic elements that distort Mendelian inheritance by selectively killing meiotic products lacking the KMD element, thereby promoting their own propagation. Although KMDs have been found in diverse eukaryotes, only a limited number of them have been characterized at the molecular level, and their killing mechanisms remain largely unknown. In this study, we identify that a gene previously deemed essential for cell survival in the fission yeast Schizosa...
• Pathogenic mechanism and therapeutic intervention of impaired N7-methylguanosine (m7G) tRNA modification AI翻译
  作者：Ma, Jieyi; Zheng, Siyi; An, Chenrui; Han, Hui; Li, Qiwen; Huang, Ying; Xiong, Gan; Chen, Shuang; Guo, Siyao; Wang, Zhaoyu; Wei, Wei; Shang, Yudan; Ji, Yushan; Yang, Cuiyun; Choe, Junho; Yuan, Quan; Fan, Yong; Zhang, Canfeng; Lin, Shuibin
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Guangzhou Medical University; Sichuan University; Sichuan University; Sun Yat Sen University; Hanyang University; Hanyang University; Hanyang University; Hanyang University; Sun Yat Sen University
  摘要：Mutations modification enzymes including the tRNA N-7-methylguanosine (m(7)G) methyltransferase complex component WDR4 were frequently found in patients with neural disorders, while the pathogenic mechanism and therapeutic intervention strategies are poorly explored. In this study, we revealed that patient-derived WDR4 mutation leads to temporal and cell-type-specific neural degeneration, and directly causes neural developmental disorders in mice. Mechanistically, WDR4 point mutation disrupts ...
• Soil viral-host interactions regulate microplastic- dependent carbon storage AI翻译
  作者：Wang, Lu; Lin, Da; Xiao, Ke - Qing; Ma, Li - Juan; Fu, Yan - Mei; Huo, Yu - Xin; Liu, Yanjie; Ye, Mao; Sun, Ming - Ming; Zhu, Dong; Rillig, Matthias C.; Zhu, Yong - Guan
  作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Hebei University; Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Nanjing Agricultural University; Free University of Berlin
  摘要：Microplastic is globally regarded as an important factor impacting biogeochemical cycles, yet our understanding of such influences is limited by the uncertainties of intricate microbial processes. By multiomics analysis, coupled with soil chemodiversity characterization and microbial carbon use efficiency (CUE), we investigated how microbial responses to microplastics impacted soil carbon cycling in a long- term field experiment. We showed that biodegradable microplastics promoted soil organic...