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作者：Nie, Wanshu; V. Kumar, Sujay; Getirana, Augusto; Zhao, Long; Wrzesien, Melissa L.; Konapala, Goutam; Ahmad, Shahryar Khalique; Locke, Kim A.; Holmes, Thomas R.; Loomis, Bryant D.; Rodell, Matthew
作者单位：Science Applications International Corporation (SAIC); Johns Hopkins University; National University of Singapore; University System of Maryland; University of Maryland College Park; United States Department of Energy (DOE); Pacific Northwest National Laboratory; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center
摘要：Climate change and human activities alter the global freshwater cycle, causing nonstationary processes as its distribution shifting overtime, yet a comprehensive understanding of these changes remains elusive. Here, we develop a remote sensing-informed terrestrial reanalysis and assess the nonstationarity of and interconnections among global water cycle components from 2003 to 2020. We highlight 20 hotspot regions where terrestrial water storage exhibits strong nonstationarity, impacting 35% o...
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作者：Zhang, Zhidian; Wayment-Steele, Hannah K.; Brixi, Garyk; Wang, Haobo; Kern, Dorothee; Ovchinnikov, Sergey
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Brandeis University; Howard Hughes Medical Institute; Brandeis University; Harvard University; Harvard University
摘要：Protein language models (pLMs) have emerged as potent tools for predicting and designing protein structure and function, and the degree to which these models fundamentally understand the inherent biophysics of protein structure stands as an open question. Motivated by a finding that pLM-based structure predictors erroneously predict nonphysical structures for protein isoforms, we investigated the nature of sequence context needed for contact predictions in the pLM Evolutionary Scale Modeling (...
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作者：Lisberger, Stephen G.
作者单位：Duke University
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作者：Ramani, Arjun; Alcedo, Joel; Bloom, Nicholas
作者单位：Massachusetts Institute of Technology (MIT); Stanford University
摘要：In recent decades, economic activity has become increasingly concentrated in major global metropolises. Yet, the rise of working from home threatens this dominance of cities. Using multiple high- frequency datasets on spending, commuting, migration, and housing, we provide global evidence that remote work has dispersed economic activity away from city centers. We label this the Donut Effect, which is much larger and more persistent in cities with high levels of remote work. Using detailed hous...
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作者：Nerger, Bryan A.; Kashyap, Kirti; Deveney, Brendan T.; Lou, Junzhe; Hanan, Blake F.; Liu, Qi; Khalil, Andrew; Lungjangwa, Tenzin; Cheriyan, Maria; Gupta, Anupam; Jaenisch, Rudolf; Weitz, David A.; Mahadevan, L.; Mooney, David J.
作者单位：Harvard University; Harvard University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Hyderabad; Massachusetts Institute of Technology (MIT); Whitehead Institute; Harvard University; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University
摘要：Extracellular matrix (ECM) viscoelasticity broadly regulates cell behavior. While hydrogels can approximate the viscoelasticity of native ECM, it remains challenging to recapitulate the rapid stress relaxation observed in many tissues without limiting the mechanical stability of the hydrogel. Here, we develop macroporous alginate hydrogels that have an order of magnitude increase in the rate of stress relaxation as compared to bulk hydrogels. The increased rate of stress relaxation occurs acro...
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作者：Sedky, Girguis; Simon, Nathaniel; Othman, Ahmed K.; Wiswell, Hannah; Wissa, Aimy
作者单位：Princeton University
摘要：Multiple rows of feathers, known as the covert feathers, contour the upper and lower surfaces of bird wings. These feathers have been observed to deploy passively during high angle of attack maneuvers and are suggested to play an aerodynamic role. However, there have been limited attempts to capture their underlying flow physics or assess the function of multiple covert rows. Here, we first identify two flow control mechanisms associated with a single covert-inspired flap and their location se...
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作者：Wang, Hui; Nagalingam, Sanjeevi; Welch, Allison M.; Leong, Christopher; Czimczik, C. I.; Guenther, Alex B.
作者单位：University of California System; University of California Irvine
摘要：Biogenic isoprene emissions from herbaceous plants are generally lower than those from trees. However, our study finds widespread isoprene emission in herbaceous sedge plants, with a stronger temperature response surpassing current tree- derived models. We measured and compared isoprene emissions from sedges grown in different climatic zones, all showing an exponential temperature response with a Q10 range of 7.2 to 12, significantly higher than the Q10 of about 3 for other common isoprene emi...
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作者：Westmoreland, Dana E.; Feliciano, Patricia R.; Kang, Gyunghoon; Cui, Chang; Kim, Albert; Stubbe, Joanne; Nocera, Daniel G.; Drennan, Catherine L.
作者单位：Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University
摘要：Ribonucleotide reductases (RNRs) reduce ribonucleotides to deoxyribonucleotides using radical-based chemistry. For class Ia RNRs, the radical species is stored in a separate subunit (beta 2) from the subunit housing the active site (alpha 2), requiring the formation of a short-lived alpha 2 beta 2 complex and long-range radical transfer (RT). RT occurs via proton-coupled electron transfer (PCET) over a long distance (similar to 32-angstrom) and involves the formation and decay of multiple amin...
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作者：Lowman, Heili E.; Desiervo, Melissa; Hall Jr, Robert O.; Jahner, Joshua P.; Jimoh, Saheed O.; Laughlin, Daniel C.; Patterson, Amy C.; Lehman, Christopher Weiss-; Barbosa, Carolina C.; Bell, Katherine L.; Blaszczak, Joanna R.; Buerkle, C. Alex; Carter, Alice M.; Collins, Sarah M.; Deleo, Victoria; Dunkle, Matt; Gannon, Dustin; Grames, Eliza M.; Harrison, Joshua G.; Mcfarlane, S. Eryn; Oleksy, Isabella; Powers, Breanna F.; Ray, Courtenay; Stears, Alice; Summers, Betsy; Torrens, Christa L.; Trentman, Matt; Werner, Chhaya M.; Shoemaker, Lauren G.
作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; University of Wyoming; Union College; University of Montana System; University of Montana; University of Wyoming; Colorado State University System; Colorado State University Fort Collins; Nevada System of Higher Education (NSHE); University of Nevada Reno; Oregon State University; State University of New York (SUNY) System; Binghamton University, SUNY; York University - Canada; University of Colorado System; University of Colorado Boulder; Northern Arizona University; Northern Arizona University; University of Montana System; University of Montana
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作者：Georgiev, Dimitar; Fernandez-Galiana, Alvaro; Pedersen, Simon Vilms; Papadopoulos, Georgios; Xie, Ruoxiao; Stevens, Molly M.; Barahona, Mauricio
作者单位：Imperial College London; Imperial College London; Imperial College London; Imperial College London; Imperial College London; University of Oxford; University of Oxford; University of Oxford; Imperial College London
摘要：Raman spectroscopy is widely used across scientific domains to characterize the chemical composition of samples in a nondestructive, label-free manner. Many applications entail the unmixing of signals from mixtures of molecular species to identify the individual components present and their proportions, yet conventional methods for chemometrics often struggle with complex mixture scenarios encountered in practice. Here, we develop hyperspectral unmixing algorithms based on autoencoder neural n...
