45期

最新文章

• Pan- ErbB inhibition impairs cognition via disrupting myelination and aerobic glycolysis in oligodendrocytes AI翻译
  作者：Hu, Xu; Zhu, Qingyu; Lou, Tianjie; Hu, Qianqian; Li, Huashun; Xu, Yijia; Niu, Xiaojie; He, Li; Huang, Hao; Qiu, Mengsheng; Shen, Ying; Jia, Jie-Min; Tao, Yanmei
  作者单位：Zhejiang University; Southeast University - China; Southeast University - China; Hangzhou Normal University; Westlake Laboratory; Westlake University; Zhejiang University
  摘要：White matter (WM) abnormalities are an emerging feature of schizophrenia, yet the underlying pathophysiological mechanisms are largely unknown. Disruption of ErbB signaling, which is essential for peripheral myelination, has been genetically associated with schizophrenia and WM lesions in schizophrenic patients. However, the roles of ErbB signaling in oligodendrocytes remain elusive. Here, we used an in vivo pan-ErbB inhibition strategy and demonstrated the functions of endogenous ErbB recepto...
• FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR AI翻译
  作者：Li, Minle; Chen, Xuan; Qu, Pengfei; Shao, Zhiying; Shi, Lei; Quan, Haoyu; Zhao, Xue; Xu, Jian; Shi, Luling; Chen, Silu; Zheng, Junnian; Pan, Zhen-Qiang; Bai, Jin
  作者单位：Xuzhou Medical University; Xuzhou Medical University; Nanjing Medical University; Xuzhou Medical University; Xuzhou Medical University; Icahn School of Medicine at Mount Sinai
  摘要：Inflammatory bowel disease (IBD) is a considerable threat to human health with a significant risk for colorectal cancer (CRC). However, currently, both the molecular pathogenesis and therapeutic treatment of IBD remain limited. In this report, using both systemic and intestinal epithelium- specific gene knockout mouse models, we demonstrate that FBXO22, a substrate receptor within the SKP1- Cullin 1- F- box family of E3 ubiquitin ligases, plays an inhibitory role in the Azoxymethane/Dextran So...
• The international empirics of management AI翻译
  作者：Scur, Daniela; Ohlmacher, Scott; Van Reenen, John; Bennedsen, Morten; Bloom, Nick; Choudhary, Ali; Foster, Lucia; Groenewegen, Jesse; Grover, Arti; Hardeman, Sjoerd; Iacovone, Leonardo; Kambayashi, Ryo; Laible, Marie-Christine; Lemos, Renata; Li, Hongbin; Linarello, Andrea; Maliranta, Mika; Medvedev, Denis; Meng, Charlotte; Touya, John Miles; Mandirola, Natalia; Ohlsbom, Roope; Ohyama, Atsushi; Patnaik, Megha; Pereira-Lopez, Mariana; Sadun, Raffaella; Senga, Tatsuro; Qian, Franklin; Zimmermann, Florian
  作者单位：Cornell University; Federal Reserve System - USA; Federal Reserve System Board of Governors; University of London; London School Economics & Political Science; University of Copenhagen; Stanford University; Loughborough University; Utrecht University; The World Bank; The World Bank; The World Bank; Stanford University; European Central Bank; Bank of Italy; University of London; Queen Mary University London; University of Barcelona; The National Land Survey of Finland; Finnish Geospatial Research Institute (FGI); Hitotsubashi University; Luiss Guido Carli University; Harvard University; University of North Carolina; University of North Carolina Chapel Hill
  摘要：A country's national income broadly depends on the quantity and quality of workers and capital. But how well these factors are managed within and between firms may be a key determinant of a country's productivity and its GDP. Although social scientists have long studied the role of management practices in shaping business performance, their primary tool has been individual case studies. While useful for theory-building, such qualitative work is hard to scale and quantify. We present a large, s...
• A novel N4,N4-dimethylcytidine in the archaeal ribosome enhances hyperthermophily AI翻译
  作者：Fluke, Kristin A.; Dai, Nan; Wolf, Eric J.; Fuchs, Ryan T.; Ho, P. Shing; Talbott, Victoria; Elkins, Liam; Tsai, Yueh - Lin; Schiltz, Jackson; Febvre, Hallie P.; Czarny, Ryan; Robb, G. Brett; Correa Jr, Ivan R.; Santangelo, Thomas J.
  作者单位：Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; New England Biolabs
  摘要：Ribosome structure and activity are challenged at high temperatures, often demanding modifications to ribosomal RNAs (rRNAs) to retain translation fidelity. LC- MS/MS, bisulfite- sequencing, and high- resolution cryo-EM structures of the archaeal ribosome identified an RNA modification, N 4, N 4- dimethylcytidine (m42C), at the universally conserved C918 in the 16S rRNA helix 31 loop. Here, we characterize and structurally resolve a class of RNA methyltransferase that generates m42C whose func...
• Capturing the mechanosensitivity of cell proliferation in models of epithelium AI翻译
  作者：Hoellring, Kevin; Nuic, Lovro; Rogic, Luka; Kaliman, Sara; Gehrer, Simone; Wollnik, Carina; Rehfeldt, Florian; Hubert, Maxime; Smith, Ana-Suncana
  作者单位：University of Erlangen Nuremberg; Rudjer Boskovic Institute; University of Gottingen; University of Bayreuth
  摘要：Despite the primary role of cell proliferation in tissue development and homeostatic maintenance, the interplay between cell density, cell mechanoresponse, and cell growth and division is not yet understood. In this article, we address this issue by reporting on an experimental investigation of cell proliferation on all time- and length-scales of the development of a model tissue, grown on collagen-coated glass or deformable substrates. Through extensive data analysis, we demonstrate the relat...
• Hyponatremia unleashes neutrophil extracellular traps elevating life- threatening pulmonary embolism risk AI翻译
  作者：Inoue, Minoru; Takayama, Kazuo; Hashimoto, Rina; Enomoto, Masahiro; Date, Naoki; Ohsumi, Akihiro; Mizowaki, Takashi
  作者单位：Kyoto University; Kyoto University; Shizuoka Cancer Center; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; Kyoto University
  摘要：Neutrophil extracellular traps (NETs), essential for controlling infections, can induce various pathologies when dysregulated. Known triggers for infection- independent NETs release exist, yet a comprehensive understanding of the conditions prompting such responses is lacking. In this study, we identify hyponatremia as an independent inducer of NETs release, a common clinical condition that disrupts sodium/calcium exchange within neutrophils. This disruption leads to an excess of intracellular...
• Individual differences in information demand have a low dimensional structure predicted by some curiosity traits AI翻译
  作者：Jach, Hayley K.; Cools, Roshan; Frisvold, Alex; Grubb, Michael A.; Hartley, Catherine A.; Hartmann, Jochen; Hunter, Laura; Jia, Ruonan; de Lange, Floris P.; Larisch, Ruby; Hill, Rosa Lavelle-; Levy, Ifat; Li, Yutong; van Lieshout, Lieke L. F.; Nussenbaum, Kate; Ravaioli, Silvio; Wang, Siyu; Wilson, Robert; Woodford, Michael; Murayama, Kou; Gottlieb, Jacqueline
  作者单位：Eberhard Karls University of Tubingen; University of Melbourne; Radboud University Nijmegen; Radboud University Nijmegen; University of Arizona; Trinity College; New York University; Columbia University; Yale University; Yale University; University of Copenhagen; University of Copenhagen; Yale University; Yale University; Yale University; Princeton University; Columbia University; Cornerstone Research
  摘要：To understand human learning and progress, it is crucial to understand curiosity. But how consistent is curiosity's conception and assessment across scientific research disciplines? We present the results of a large collaborative project assessing the correspondence between curiosity measures in personality psychology and cognitive science. A total of 820 participants completed 15 personality trait measures and 9 cognitive tasks that tested multiple aspects of information demand. We show that ...
• Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade AI翻译
  作者：Arulraj, Theinmozhi; Wang, Hanwen; Deshpande, Atul; Varadhan, Ravi; Emens, Leisha A.; Jaffee, Elizabeth M.; Fertig, Elana J.; Santa-Maria, Cesar A.; Popel, Aleksander S.
  作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Kaiser Permanente; Johns Hopkins University
  摘要：Patients with metastatic triple- negative breast cancer (TNBC) show variable responses to PD- 1 inhibition. Efficient patient selection by predictive biomarkers would be desirable but is hindered by the limited performance of existing biomarkers. Here, we leveraged in silico patient cohorts generated using a quantitative systems pharmacology model of metastatic TNBC, informed by transcriptomic and clinical data, to explore potential ways to improve patient selection. We evaluated and quantifie...
• Experimental coral reef communities transform yet persist under mitigated future ocean warming and acidification AI翻译
  作者：Jury, Christopher P.; Bahr, Keisha D.; Cros, Annick; Dobson, Kerri L.; Freel, Evan B.; Graham, Andrew T.; McLachlan, Rowan H.; Nelson, Craig E.; Price, James T.; de Souza, Mariana Rocha; Shizuru, Leah; Smith, Celia M.; Sparagon, Wesley J.; Squair, Cheryl A.; Timmers, Molly A.; Vicente, Jan; Webb, Maryann K.; Yamase, Nicole H.; Grottoli, Andrea G.; Toonen, Robert J.
  作者单位：University of Hawaii System; University of Hawaii Manoa; Texas A&M University System; Nature Conservancy; University of Southampton; NERC National Oceanography Centre; University System of Ohio; Ohio State University; Oregon State University; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; National Geographic Society
  摘要：Coral reefs are among the most sensitive ecosystems affected by ocean warming and acidification, and are predicted to collapse over the next few decades. Reefs are predicted to shift from net accreting calcifier- dominated systems with exceptionally high biodiversity to net eroding algal- dominated systems with dramatically reduced biodiversity. Here, we present a two- year experimental study examining the responses of entire mesocosm coral reef communities to warming (+2 degrees C), acidifica...
• Characterization of RNA editing and gene therapy with a compact CRISPR-Cas13 in the retina AI翻译
  作者：Kumar, Satheesh; Hsiao, Yi - Wen; Wong, Vickie H. Y.; Aubin, Deborah; Wang, Jiang - Hui; Lisowski, Leszek; Rakoczy, Elizabeth P.; Li, Fan; Martinez, Luis Alarcon -; Cordero, Anai Gonzalez -; Bui, Bang V.; Liu, Guei-Sheung
  作者单位：Royal Victorian Eye & Ear Hospital; Centre for Eye Research Australia; University of Melbourne; University of Tasmania; Menzies Institute for Medical Research; University of Melbourne; University of Sydney; Children's Medical Research Institute - Australia; University of Sydney; Children's Medical Research Institute - Australia; University of Sydney; Military Institute of Aviation Medicine; Children's Medical Research Institute - Australia; NSW Health; Sydney Childrens Hospitals Network; University of Western Australia; Sun Yat Sen University
  摘要：CRISPR-Cas13 nucleases are programmable RNA- targeting effectors that can silence gene expression in a transient manner. Recent iterations of Cas13 nucleases are compact for adeno- associated virus (AAV) delivery to achieve strong and persistent expression of various organs in a safe manner. Here, we report significant transcriptomic signatures of Cas13bt3 expression in retinal cells and show all- in- one AAV gene therapy with Cas13bt3 can effectively silence VEGFA mRNA in human retinal organo...