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作者：Romano, Keith P.; Bagnall, Josephine; Warrier, Thulasi; Sullivan, Jaryd; Ferrara, Kristina; Orzechowski, Marek; Nguyen, Phuong H.; Raines, Kyra; Livny, Jonathan; Shoresh, Noam; Hung, Deborah T.
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School
摘要：The rising prevalence of antibiotic resistance threatens human health. While more sophisticated strategies for antibiotic discovery are being developed, target elucidation of new chemical entities remains challenging. In the postgenomic era, expression profiling can play an important role in mechanism- of- action (MOA) prediction by reporting on the cellular response to perturbation. However, the broad application of transcriptomics has yet to fulfill its promise of transforming target elucida...
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作者：Yu, Leilei; Zhang, Chengcheng; Zhai, Qixiao
作者单位：Jiangnan University; Jiangnan University; Jiangnan University
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作者：Ren, Ya- Ning; Ren, Hui- Ying; Watanabe, Kenji; Taniguchi, Takashi; He, Lin
作者单位：Beijing Normal University; National Institute for Materials Science; National Institute for Materials Science
摘要：Two- dimensional (2D) moir & eacute; systems based on twisted bilayer graphene and transition metal dichalcogenides provide a promising platform to investigate emergent phenomena driven by strong electron-electron interactions in partially filled flat bands. A natural question arises: Is it possible to expand the 2D correlated moir & eacute; physics to one- dimensional (1D) that electron-electron correlation is expected to be further enhanced? This requires selectively doping of 1D moir & eacu...
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作者：Zhang, Zhihua; Yu, Ran; Shi, Qiuwen; Wu, Zhi-Jing; Li, Qingchun; Mu, Jian; Chen, Biaobang; Shi, Juanzi; Ni, Renmin; Wu, Ling; Li, Qiaoli; Fu, Jing; Li, Rong; Sun, Xiaoxi; Wang, Jiucun; He, Lin; Kuang, Yanping; Sang, Qing; Wang, Lei
作者单位：Fudan University; Guangxi Medical University; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Binzhou Medical University; Shanghai Academy of Science & Technology; Shanghai Jiao Tong University; Fudan University; Fudan University; Shanghai Jiao Tong University
摘要：Mitochondria play diverse roles in mammalian physiology. The architecture, activity, and physiological functions of mitochondria in oocytes are largely different from those in somatic cells, but the mitochondrial proteins related to oocyte quality and reproductive longevity remain largely unknown. Here, using whole-exome sequencing data from 1,024 women (characterized by oocyte maturation arrest and degenerated or morphologically abnormal oocytes) and 2,868 healthy controls, we performed a pop...
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作者：Kim, Jaewon; Altman, Ehud; Chatterjee, Shubhayu
作者单位：University of California System; University of California Berkeley; Carnegie Mellon University
摘要：Several strongly correlated metals display B-linear magnetoresistance (LMR) with a universal slope, in sharp contrast to the B 2 scaling predicted by Fermi liquid theory. We provide a unifying explanation of the origin of LMR by focusing on a common feature in their phase diagrams-proximity to symmetry-breaking orders. Specifically, we demonstrate via two microscopic models that LMR with a universal slope arises ubiquitously near ordered phases, provided the order parameter either i) has a fin...
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作者：Biswas, Leelabati; Tyc, Katarzyna M.; Aboelenain, Mansour; Sun, Siqi; Dundovic, Iva; Vukusic, Kruno; Liu, Jason; Guo, Vanessa; Xu, Min; Scott, Richard T.; Tao, Xin; Tolic, Iva M.; Xing, Jinchuan; Schindler, Karen
作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Egyptian Knowledge Bank (EKB); Mansoura University; Rudjer Boskovic Institute; Rutgers University System; Rutgers University New Brunswick
摘要：The female reproductive lifespan is highly dependent on egg quality, especially the presence of a normal number of chromosomes in an egg, known as euploidy. Mistakes in meiosis leading to egg aneuploidy are frequent in humans. Yet, knowledge of the precise genetic landscape that causes egg aneuploidy in women is limited, as phenotypic data on the frequency of human egg aneuploidy are difficult to obtain and therefore absent in public genetic datasets. Here, we identify genetic determinants of ...
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作者：Carriquiry, Alicia; Ommen, Danica M.
作者单位：Iowa State University
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作者：Rosenblum, Michael; Chin, Elizabeth T.; Ogburn, Elizabeth L.; Nishimura, Akihiko; Westreich, Daniel; Datta, Abhirup; Vanderplas, Susan; Cuellar, Maria; Thompson, William C.
作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Nebraska System; University of Nebraska Lincoln; University of Pennsylvania; University of Pennsylvania; University of California System; University of California Irvine
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作者：Zioga, Maria; Kotz, Maximilian; Levermann, Anders
作者单位：Potsdam Institut fur Klimafolgenforschung; University of Potsdam; Humboldt University of Berlin
摘要：Historically, economic growth has been closely coupled to carbon emissions responsible for climate change, but to stabilize global mean temperature, net- zero carbon emissions are necessary. Some economies have begun to reduce emissions while continuing to grow, but this decoupling is not fast enough to achieve global climate targets. Subnational climate actions seem to be crucial for the achievement of these targets. Here, we uncover the effectiveness of subnational efforts by estimating deco...
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作者：Hu, Xiaojing
