45期

最新文章

• A comprehensive transcriptome characterization of individual nuclear receptor pathways in the human small intestine AI翻译
  作者：Willemsen, Sam; Yengej, Fjodor A. Yousef; Puschhof, Jens; Rookmaaker, Maarten B.; Verhaar, Marianne C.; van Es, Johan; Beumer, Joep; Clevers, Hans
  作者单位：Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center; Helmholtz Association; German Cancer Research Center (DKFZ); Roche Holding; Princess Maxima Center; Roche Holding
  摘要：Nuclear receptors (NRs) are widely expressed transcription factors that bind small, lipophilic compounds and regulate diverse biological processes. In the small intestine, NRs are known to act as sensors that control transcriptional responses to endogenous and exogenous signals, yet their downstream effects have not been characterized extensively. Here, we investigate the activation of six different NRs individually in human intestinal organoids using small molecules agonists. We observe chang...
• Political practitioners poorly predict which messages persuade the public AI翻译
  作者：Broockman, David E.; Kalla, Joshua L.; Caballero, Christian; Easton, Matthew
  作者单位：University of California System; University of California Berkeley; Yale University
  摘要：Do political practitioners have good intuitions about how to persuade the public? Longstanding theories that political elites' messages have large effects on public opinion and the large sums spent to secure some practitioners' messaging advice suggest they should. However, findings regarding the surprising limits of expert forecasts in other domains suggest they may not. In this paper, we evaluate how well political practitioners can predict which messages are most persuasive. We measured the...
• Stop using racist, unethical, and inappropriate names in taxonomy AI翻译
  作者：Chala, Desalegn; Endresen, Dag; Demissew, Sebsebe; Slaughter, Laura A.; Johnsen, Einar Broch; Stenseth, Nils Chr.
  作者单位：University of Oslo; Addis Ababa University; University of Oslo; University of Oslo; University of Oslo; Addis Ababa University
• Open ocean convection drives enhanced eastern pathway of the glacial Atlantic Meridional Overturning Circulation AI翻译
  作者：Gu, Sifan; Liu, Zhengyu; Ng, Hong Chin; Lynch-Stieglitz, Jean; Mcmanus, Jerry F.; Spall, Michael; Jahn, Alexandra; He, Chengfei; Li, Lingwei; Yan, Mi; Wu, Lixin
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; University System of Ohio; Ohio State University; Nanjing Normal University; University of Bristol; University System of Georgia; Georgia Institute of Technology; Columbia University; Woods Hole Oceanographic Institution; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Miami; Ocean University of China
  摘要：Abundant proxy records suggest a profound reorganization of the Atlantic Meridional Overturning Circulation (AMOC) during the Last Glacial Maximum (LGM, similar to 21,000 y ago), with the North Atlantic Deep Water (NADW) shoaling significantly relative to the present-day (PD) and forming Glacial North Atlantic Intermediate Water (GNAIW). However, almost all previous observational and modeling studies have focused on the zonal mean two-dimensional AMOC feature, while recent progress in the unde...
• Strain learning in protein-based mechanical metamaterials AI翻译
  作者：Sadaba, Naroa; Sanchez-Rexach, Eva; Waltmann, Curt; Hilburg, Shayna L.; Pozzo, Lilo D.; de la Cruz, Monica Olvera; Sardon, Haritz; Meza, Lucas R.; Nelson, Alshakim
  作者单位：University of Washington; University of Washington Seattle; University of Basque Country; POLYMAT; University of Basque Country; Northwestern University; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：Mechanical deformation of polymer networks causes molecular-level motion and bond scission that ultimately lead to material failure. Mitigating this strain-induced loss in mechanical integrity is a significant challenge, especially in the development of active and shape-memory materials. We report the additive manufacturing of mechanical metamaterials made with a protein-based polymer that undergo a unique stiffening and strengthening behavior after shape recovery cycles. We utilize a bovine s...
• Aligning the smiles of dating dyads causally increases attraction AI翻译
  作者：Sarah, Pablo Arias-; Bedoya, Daniel; Daube, Christoph; Aucouturier, Jean- Julien; Hall, Lars; Johansson, Petter
  作者单位：Lund University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Information Sciences & Technologies (INS2I); Sorbonne Universite; Universite Marie et Louis Pasteur; Centre National de la Recherche Scientifique (CNRS)
  摘要：Social interaction research is lacking an experimental paradigm enabling researchers to make causal inferences in free social interactions. For instance, the expressive signals that causally modulate the emergence of romantic attraction during interactions remain unknown. To disentangle causality in the wealth of covarying factors that govern social interactions, we developed an open- source video- conference platform enabling researchers to covertly manipulate the social signals produced by p...
• Adaptive CVgen: Leveraging reinforcement learning for advanced sampling in protein folding and chemical reactions AI翻译
  作者：Shen, Wenhui; Wan, Kaiwei; Li, Dechang; Gao, Huajian; Shi, Xinghua
  作者单位：Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Zhejiang University; Tsinghua University
  摘要：Enhanced sampling techniques have traditionally encountered two significant challenges: identifying suitable reaction coordinates and addressing the exploration-exploitation dilemma, particularly the difficulty of escaping local energy minima. Here, we introduce Adaptive CVgen, a universal adaptive sampling framework designed to tackle these issues. Our approach utilizes a set of collective variables (CVs) to comprehensively cover the system's potential evolutionary phase space, generating div...
• Learning- dependent gating of hippocampal inputs by frontal interneurons AI翻译
  作者：Zhang, Chun-Lei; Sontag, Lucile; Gomez-Ocadiz, Ruy; Schmidt-Hieber, Christoph
  作者单位：Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Friedrich Schiller University of Jena; Sorbonne Universite; Karolinska Institutet
  摘要：The hippocampus is a brain region that is essential for the initial encoding of episodic memories. However, the consolidation of these memories is thought to occur in the neocortex, under guidance of the hippocampus, over the course of days and weeks. Communication between the hippocampus and the neocortex during hippocampal sharp wave- ripple oscillations is believed to be critical for this memory consolidation process. Yet, the synaptic and circuit basis of this communication between brain a...
• Identification of a divalent metal transporter required for cellular iron metabolism in malaria parasites AI翻译
  作者：Loveridge, Kade M.; Sigala, Paul A.
  作者单位：Utah System of Higher Education; University of Utah
  摘要：Plasmodium falciparum malaria parasites invade and multiply inside red blood cells (RBCs), the most iron- rich compartment in humans. Like all cells, P. falciparum requires nutritional iron to support essential metabolic pathways, but the critical mechanisms of iron acquisition and trafficking during RBC infection have remained obscure. Parasites internalize and liberate massive amounts of heme during large- scale digestion of RBC hemoglobin within an acidic food vacuole (FV) but lack a heme o...
• Effects of oxycodone on placental lineages: Evidence from the transcriptome profile of mouse trophoblast giant cells AI翻译
  作者：Lyu, Zhen; Kinkade, Jessica A.; Bivens, Nathan J.; Roberts, R. Michael; Joshi, Trupti; Rosenfeld, Cheryl S.
  作者单位：University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia
  摘要：Pregnant women are often prescribed or abuse opioid drugs. The placenta is likely the key to understanding how opioids cause adverse pregnancy outcomes. Maternal oxycodone (OXY) exposure of pregnant mice leads to disturbances in the layer of invasive parietal trophoblast giant cells (pTGC) that forms the interface between the placenta and uterus. These cells are analogous to extravillous trophoblasts of the human placenta. They are crucial to coordinating the metabolic needs of the conceptus w...