45期

最新文章

• A molecular view of peptoid- induced acceleration of calcite growth AI翻译
  作者：Zhang, Mingyi; Chen, Ying; Wu, Chunhui; Zheng, Renyu; Xia, Ying; Saccuzzo, Emily G.; Trinh, Thi Kim Hoang; Mondarte, Evan Angelo Quimada; Nakouzi, Elias; Rad, Behzad; Legg, Benjamin A.; Shaw, Wendy J.; Tao, Jinhui; De Yoreo, James J.; Chen, Chun-Long
  作者单位：United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：The extensive deposits of calcium carbonate (CaCO3) generated by marine organisms constitute the largest and oldest carbon dioxide (CO2) reservoir. These organisms utilize macromolecules like peptides and proteins to facilitate the nucleation and growth of carbonate minerals, serving as an effective method for CO2 sequestration. However, the precise mechanisms behind this process remain elusive. In this study, we report the use of sequence- defined peptoids, a class of peptidomimetics, to achi...
• Biochemical analysis of EGFR exon20 insertion variants insASV and insSVD and their inhibitor sensitivity AI翻译
  作者：Zhao, Hanchen; Beyett, Tyler S.; Jiang, Jie; Rana, Jaimin K.; Schaeffner, Ilse K.; Santana, Jhasmer; Janne, Pasi A.; Eck, Michael J.
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Emory University
  摘要：Somatic mutations in the epidermal growth factor receptor (EGFR) are a major cause of non-small cell lung cancer. Among these structurally diverse alterations, exon 20 insertions represent a unique subset that rarely respond to EGFR tyrosine kinase inhibitors (TKIs). Therefore, there is a significant need to develop inhibitors that are active against this class of activating mutations. Here, we conducted biochemical analysis of the two most frequent exon 20 insertion variants, V769_D770insASV ...
• SPATEs promote the survival of Shigella to the plasma complement system upon local hemorrhage and bacteremia AI翻译
  作者：Debande, Lorine; Sabbah, Ahmad; Kuhn, Lauriane; Ngondo, Richard Patry; Maucotel, Julie; Valente- Barroso, Marina; Andre, Antonin C.; Roche, Beatrice; Laborde, Matthieu; Cantalapiedra-Mateo, Maria- Victoria; Thahouly, Tamou; Milinski, Ana; Bianchetti, Laurent; Allmang, Christine; Frugier, Magali; Marteyn, Benoit S.
  作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg
  摘要：Shigella spp. are the causative agents of shigellosis, which remains a leading cause of death in children under the age of 5. Symptoms of shigellosis include bloody diarrhea, associated to colon hemorrhage; in more severe cases, Shigella bacteremia is induced. These clinical features indicate that Shigella are exposed and survive exposure to plasma, locally and systemically, although this has not yet been studied at a molecular level. In this report, we confirmed in a guinea pig model of shige...
• A receptor kinase senses sterol by coupling with elicitins in auxotrophic Phytophthora AI翻译
  作者：Pei, Yong; Ji, Peiyun; Miao, Jinlu; Gu, Xinyi; Wang, Hui; Zhao, Yaning; Song, Wen; Guo, Zhenjie; Zhou, Hao; Shen, Danyu; Liu, Jinding; Si, Jierui; Yan, Jianyu; Ren, Yingkai; Bao, Yazhou; Yin, Zhiyuan; Dou, Daolong
  作者单位：Nanjing Agricultural University; Nanjing Agricultural University
  摘要：Sterols are vital nutrients and signals for eukaryotic organisms. Mammalian cells are known to sense and respond to sterol status changes to maintain them within strict limits, a process associated with various human diseases. However, this process is not understood in oomycete pathogens, most of which are sterol auxotrophic and must obtain sterols from host plants. Here, we report that Phytophthora sojae SSRK1 (sterol- sensing receptor kinase 1) detects host sterols by coupling with elicitins...
• Differential neural mechanisms underlie cortical gating of visual spatial attention mediated by alpha- band oscillations AI翻译
  作者：Yang, Xiaofang; Fiebelkorn, Ian C.; Jensen, Ole; Knight, Robert T.; Kastner, Sabine
  作者单位：Princeton University; Princeton University; University of Rochester; University of Rochester; University of Oxford; University of Oxford; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Selective attention relies on neural mechanisms that facilitate processing of behaviorally relevant sensory information while suppressing irrelevant information, consistently linked to alpha- band oscillations in human M/EEG studies. We analyzed cortical alpha responses from intracranial electrodes implanted in eight epilepsy patients, who performed a visual spatial attention task. Electrocorticographic data revealed a spatiotemporal dissociation between attention- modulated alpha desynchroniz...
• Phylogenetic evidence supporting the nonenveloped nature of hepadnavirus ancestors AI翻译
  作者：Buigues, Jaime; Vinals, Adria; Martinez-Recio, Raquel; Monros, Juan S.; Cuevas, Jose M.; Sanjuan, Rafael
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); University of Valencia; University of Valencia; University of Valencia
  摘要：Reverse- transcribing animal DNA viruses include the hepadnaviruses, a well- characterized family of small enveloped viruses that infect vertebrates but also a sister group of nonenveloped viruses more recently discovered in fish and termed the nackednaviruses. Here, we describe the complete sequence of a virus found in the feces of an insectivorous bat, which encodes a core protein and a reverse transcriptase but no envelope protein. A database search identified a viral sequence from a permaf...
• Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments AI翻译
  作者：Garaizar, Adiran; Diaz- Oviedo, David; Zablowsky, Nina; Rissanen, Sami; Koebberling, Johannes; Sun, Jiawei; Steiger, Christoph; Steigemann, Patrick; Mann, Florian A.; Meier, Katharina
  作者单位：Bayer AG; Bayer Healthcare Pharmaceuticals; Bayer AG; Bayer CropScience; Bayer AG; Bayer Healthcare Pharmaceuticals
  摘要：The use of lipid nanoparticles (LNPs) for therapeutic RNA delivery has gained significant interest, particularly highlighted by recent milestones such as the approval of Onpattro and two mRNA-based SARS-CoV-2 vaccines. However, despite substantial advancements in this field, our understanding of the structure and internal organization of RNA-LNPs -and their relationship to efficacy, both in vitro and in vivo- remains limited. In this study, we present a coarse- grained molecular dynamics (MD) ...
• Inclusive fitness consequences of dispersal decisions in a cooperatively breeding bird, the long-tailed tit (Aegithalos caudatus) (vol 115, 12011, 2018) AI翻译
  作者：Green, Jonathan P.; Hatchwell, Ben J.
• Cellular- resolution optogenetics reveals attenuation- by- suppression in visual cortical neurons AI翻译
  作者：LaFosse, Paul K.; Zhou, Zhishang; O'Rawe, Jonathan F.; Friedman, Nina G.; Scott, Victoria M.; Deng, Yanting; Histed, Mark H.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); National Institutes of Health (NIH) - USA; University System of Maryland; University of Maryland College Park
  摘要：The relationship between neurons' input and spiking output is central to brain computation. Studies in vitro and in anesthetized animals suggest that nonlinearities emerge in cells' input-output (IO; activation) functions as network activity increases, yet how neurons transform inputs in vivo has been unclear. Here, we characterize cortical principal neurons' activation functions in awake mice using two- photon optogenetics. We deliver fixed inputs at the soma while neurons' activity varies wi...
• Persistently active El Niño-Southern Oscillation since the Mesozoic AI翻译
  作者：Li, Xiang; Hu, Shineng; Hu, Yongyun; Cai, Wenju; Jin, Yishuai; Lu, Zhengyao; Guo, Jiaqi; Lan, Jiawenjing; Lin, Qifan; Yuan, Shuai; Zhang, Jian; Wei, Qiang; Liu, Yonggang; Yang, Jun; Nie, Ji
  作者单位：Peking University; Duke University; Peking University; Ocean University of China; Ocean University of China; Xiamen University; Xiamen University; Chinese Academy of Sciences; Institute of Earth Environment, CAS; Laoshan Laboratory; Lund University
  摘要：The El Ni & ntilde;o-Southern Oscillation (ENSO), originating in the central and eastern equatorial Pacific, is a defining mode of interannual climate variability with profound impact on global climate and ecosystems. However, an understanding of how the ENSO might have evolved over geological timescales is still lacking, despite a well- accepted recognition that such an understanding has direct implications for constraining human- induced future ENSO changes. Here, using climate simulations, ...