47期

最新文章

• Reply to Majer et al.: Negotiating policy action for transformation requires both sociopolitical and behavioral perspectives AI翻译
  作者：Patterson, James J.; Feola, Giuseppe; Kim, Rakhyun E.
  作者单位：Utrecht University
• Soft matter mechanics of baseball's Rubbing Mud AI翻译
  作者：Pradeep, Shravan; Chen, Xiangyu; Seiphoori, Ali; Vann, David R.; Arratia, Paulo E.; Jerolmack, Douglas J.
  作者单位：University of Pennsylvania; University of Pennsylvania; Norwegian Geotechnical Institute, NGI
  摘要：Researchers looking for sustainable materials with optimal mechanical properties may draw inspiration from a baseball tradition. For nearly 100 y, a mysterious mud harvested from an undisclosed river site in New Jersey (USA) has been the agent of choice in the USA's Major League Baseball for de-glossing new baseballs. It is unclear, however, what makes this Rubbing Mud work. Here, we perform a multiscale investigation of the rheology and tribology of this mud material under baseball-relevant c...
• Interdisciplinary insights into the cultural and chronological context of chili pepper ( Capsicum annuum var. annuum L.) domestication in Mexico AI翻译
  作者：Chiou, Katherine L.; Lira-Noriega, Andres; Gallaga, Emiliano; Hastorf, Christine A.; Aguilar-Melendez, Araceli
  作者单位：University of Alabama System; University of Alabama Tuscaloosa; Instituto de Ecologia - Mexico; University of California System; University of California Berkeley; Universidad Veracruzana
  摘要：This study investigates the temporal and spatial factors driving the domestication of Capsicum annuum var. annuum L. in Mexico. This species exhibits the greatest morphological diversity in fruit among Capsicum species-a characteristic that is even more pronounced in contemporary landraces cultivated by indigenous communities. Despite the chili pepper's integral role in regional culinary traditions, its domestication history in this region remains poorly understood, often subject to scholarly ...
• The limitation of lipidation: Conversion of semaglutide from once-weekly to once-monthly dosing AI翻译
  作者：Schneider, Eric L.; Hangasky, John A.; Fernandez, Rocio del Valle; Ashley, Gary W.; Santi, Daniel, V
  作者单位：University of California System; University of California San Francisco
  摘要：The objective of this work was to develop a long-acting form of the lipidated peptide semaglutide that can be administered to humans once-monthly. Semaglutide was attached to hydrogel microspheres by a cleavable linker with an expected in vivo release half-life of about 1 mo. After a single subcutaneous dose, the pharmacokinetic parameters of released semaglutide and bodyweight loss were determined in mice, and results were used to estimate the dosing and pharmacokinetics of the released semag...
• Three-chamber electrochemical reactor for selective lithium extraction from brine AI翻译
  作者：Feng, Yuge; Park, Yoon; Hao, Shaoyun; Fang, Zhiwei; Terlier, Tanguy; Zhang, Xiao; Qiu, Chang; Zhang, Shoukun; Chen, Fengyang; Zhu, Peng; Nguyen, Quan; Wang, Haotian; Biswal, Sibanilisa
  作者单位：Rice University; Rice University; Rice University; Rice University; Rice University
  摘要：Efficient lithium recovery from geothermal brines is crucial for the battery industry. Current electrochemical separation methods struggle with the simultaneous presence of Na+, K+, Mg2+, and Ca2+ because these cations are similar to Li+, making it challenging to separate effectively. We address these challenges with a three-chamber reactor featuring a polymer porous solid electrolyte in the middle layer. This design improves the transference number of Li+ (tLi+) by 2.1 times compared to the t...
• Samd7 represses short- wavelength cone genes to preserve long- wavelength cone and rod photoreceptor identity AI翻译
  作者：Volkov, Leo I.; Ogawa, Yohey; Somjee, Ramiz; Vedder, Hannah E.; Powell, Hannah E.; Poria, Deepak; Meiselman, Sam; Kefalov, Vladimir J.; Corbo, Joseph C.
  作者单位：Washington University (WUSTL); University of California System; University of California Irvine
  摘要：The role of transcription factors in photoreceptor gene regulation is fairly well understood, but knowledge of the cell- type- specific function of transcriptional cofactors remains incomplete. Here, we show that the transcriptional corepressor samd7 promotes rod differentiation and represses short- wavelength cone genes in long- wavelength cones in zebrafish. In samd7-/- retinas, red cones are transformed into hybrid red/ultraviolet (UV) cones, green cones are absent, the number of blue cones...
• Machine learning reveals the transcriptional regulatory network and circadian dynamics of Synechococcus elongatus PCC 7942 (vol 121, e2410492121, 2024) AI翻译
  作者：Yuan, Yuan; Al Bulushi, Tahani; Sastry, Anand V.; Sancar, Cigdem; Szubin, Richard; Golden, Susan S.; Palsson, Bernhard O.
• Functional alterations of the magnocellular subdivision of the visual sensory thalamus in autism AI翻译
  作者：Schelinski, Stefanie; Kauffmann, Louise; Tabas, Alejandro; Mueller-Axt, Christa; von Kriegstein, Katharina
  作者单位：Technische Universitat Dresden; Max Planck Society; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Universite Savoie Mont Blanc; Basque Foundation for Science
  摘要：The long- standing hypothesis that autism is linked to changes in the visual magnocellular system of the human brain has never been directly examined due to technological to investigate this hypothesis within the visual sensory thalamus (lateral geniculate nucleus, LGN). The LGN is a crucial component of the primary visual pathway. It is particularly suited to investigate the magnocellular visual system, because within the LGN, the magnocellular (mLGN) uniquely segregates from the parvocellula...
• Structural and hydrodynamic controls on fluid travel time distributions across fracture networks AI翻译
  作者：Davy, Philippe; Le Goc, Romain; Darcel, Caroline; Pinier, Benoit; Selroos, Jan-Olof; Le Borgne, Tanguy
  作者单位：Universite de Rennes; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Swedish Nuclear Fuel & Waste Management Company (SKB); Royal Institute of Technology
  摘要：Fracture networks are preferential flow paths playing a critical role in a wide range of environmental and industrial problems. Their complex multiscale structure leads to broad distributions of fluid travel times, affecting many biogeochemical processes. Yet, the relationship between the fracture network structures, their hydrodynamic properties, and the resulting anomalous transport dynamics remains unclear. We use a large database of fracture network models to investigate the factors contro...
• Salmonella virulence factors induce amino acid malabsorption in the ileum to promote ecosystem invasion of the large intestine AI翻译
  作者：Radlinski, Lauren C.; Rogers, Andrew W. L.; Bechtold, Lalita; Masson, Hugo L. P.; Nguyen, Henry; Tiffany, Connor R.; de Carvalho, Thaynara Parente; Tsolis, Renee M.; Baumler, Andreas J.
  作者单位：University of California System; University of California Davis
  摘要：The gut microbiota produces high concentrations of antimicrobial short- chain fatty acids (SCFAs) that restrict the growth of invading microorganisms. The enteric pathogen Salmonella enterica serovar (S.) Typhimurium triggers inflammation in the large intestine to ultimately reduce microbiota density and bloom, but it is unclear how the pathogen gains a foothold in the homeostatic gut when SCFA- producing commensals are abundant. Here, we show that S. Typhimurium invasion of the ileal mucosa t...