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作者：Hou, Chunyan; Deng, Jingtao; Wu, Ci; Zhang, Jing; Byers, Stephen; Moremen, Kelley W.; Pei, Huadong; Ma, Junfeng
作者单位：Georgetown University; University System of Georgia; Georgia State University; University System of Georgia; Georgia State University; University System of Georgia; University of Georgia
摘要：As a unique type of glycosylation, O- linked beta-N- acetylglucosamine (O- GlcNAc) modification (O- GlcNAcylation) on Ser/Thr residues of proteins was discovered 40 y ago. O- GlcNAcylation is catalyzed by two enzymes: O- GlcNAc transferase (OGT) and O- GlcNAcase (OGA), which add and remove O- GlcNAc, respectively. O- GlcNAcylation is an essential glycosylation that regulates the functions of many proteins in virtually all cellular processes. However, deep and site- specific characterization of...
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作者：Long, Xiaogang; Cai, Yajun; Wang, Huamei; Liu, Yue; Huang, Xiaoyi; Xuan, Hua; Li, Wenjuan; Zhang, Xiaoling; Zhang, Hongya; Fang, Xiaofeng; He, Hang; Xu, Guoyong; Dean, Caroline; Yang, Hongchun
作者单位：Wuhan University; Hubei Hongshan Laboratory; Peking University; Wuhan University; Wuhan University; Tsinghua University
摘要：Plants use seasonal cold to time the transition to reproductive development. Shortand long- term cold exposure is registered via parallel transcriptional shutdown and Polycomb- dependent epigenetic silencing of the Arabidopsis thaliana major flowering repressor locus FLOWERING LOCUS C (FLC). The cold- induced antisense transcripts (COOLAIR) determine the dynamics of FLC transcriptional shutdown, but the thermosensory mechanisms are still unresolved. Here, through a forward genetic screen, we i...
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作者：Dong, Xingchen; Sun, Fei; Secaira-Morocho, Henry; Hui, Alisa; Wang, Ke; Cai, Chunmiao; Udgata, Shirsa; Low, Brian; Wei, Songlin; Chen, Xinyi; Qi, Ming; Pasch, Cheri A.; Xu, Wei; Jiang, Jiaoyang; Zhu, Qiyun; Huan, Tao; Deming, Dustin A.; Fu, Ting
作者单位：University of Wisconsin System; University of Wisconsin Madison; Arizona State University; Arizona State University-Tempe; University of British Columbia; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：The gut microbiota has a significant impact on the development and function of intestinal epithelial cells (IECs) by modifying bile acid (BA) metabolites. Recently, specific gut microbiome- derived BAs, such as 7- oxo- deoxycholic acid (7- oxo-DCA) and isodeoxycholic acid (isoDCA), have been identified to be shifted inversely in colitis and hepatic liver diseases. Although the responsible gut microbes have been identified, metabolites' effects on IECs remain largely unclear. We found that alth...
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作者：Jagst, Michelle; Goemer, Andre; Augustyniak, Sanja; Kloehn, Mara; Rehm, Adriana; Ulrich, Rainer G.; Bader, Verian; Winklhofer, Konstanze F.; Brueggemann, Yannick; Gold, Ralf; Gisevius, Barbara; Todt, Daniel; Steinmann, Eike
作者单位：Ruhr University Bochum; University of Veterinary Medicine Hannover; Ruhr University Bochum; Friedrich Loeffler Institute; German Center for Infection Research; Ruhr University Bochum; German Center for Infection Research
摘要：Hepatitis E virus (HEV) infections are one of the most common causes of acute viral hepatitis, annually causing over 3 million symptomatic cases and 70,000 deaths worldwide. Historically, HEV was described as a hepatotropic virus, but has recently been associated with various extrahepatic manifestations including neurological disorders such as Guillain-Barre syndrome and neuralgic amyotrophy. However, the underlying pathogenesis of these neurological diseases remains largely unknown. The aim o...
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作者：Jimmidi, Ravikumar; Monsivais, Diana; Ta, Hai Minh; Sharma, Kiran L.; Bohren, Kurt M.; Chamakuri, Srinivas; Liao, Zian; Li, Feng; Hakenjos, John M.; Li, Jian - Yuan; Mishina, Yuji; Pan, Haichun; Qin, Xuan; Robers, Matthew B.; Sankaran, Banumathi; Tan, Zhi; Tang, Suni; Vasquez, Yasmin M.; Wilkinson, Jennifer; Young, Damian W.; Palmer, Stephen S.; Mackenzie, Kevin R.; Kim, Choel; Matzuk, Martin M.
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; University of Michigan System; University of Michigan; Promega Corporation; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Baylor College of Medicine
摘要：Activin receptor type 1 (ACVR1; ALK2) and activin receptor like type 1 (ACVRL1; ALK1) are transforming growth factor beta family receptors that integrate extracellular signals of bone morphogenic proteins (BMPs) and activins into Mothers Against Decapentaplegichomolog 1/5 (SMAD1/SMAD5) signaling complexes. Several activating mutations in ALK2 are implicated in fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine gliomas, and ependymomas. The ALK2 R206H mutation is also presen...
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作者：Du, Yingying; Chen, Hui; Zhou, Lei; Guo, Qunfeng; Gong, Shuangming; Feng, Siyuan; Guan, Qiujing; Shi, Peilin; Lv, Tongxin; Guo, Yilan; Yang, Cheng; Sun, Peng; Li, Kun; Xu, Shuogui; Li, Lei
作者单位：East China Normal University; Fudan University; East China Normal University; East China Normal University; Shanghai Jiao Tong University; Naval Medical University; East China Normal University; East China Normal University; Naval Medical University; East China Normal University; East China Normal University
摘要：Primary osteoporosis, manifesting as decreased bone mass and increased bone fragility, is a silent disease that is often ignored until a bone breaks. Accordingly, it is urgent to develop reliable biomarkers and novel therapeutic strategies for osteoporosis treatment. Here, we identified REG gamma as a potential biomarker of osteoporotic populations through proteomics analysis. Next, we demonstrated that REG gamma deficiency increased osteoclast activity and triggered bone mass loss in REG gamm...
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作者：Gonzalez, Reyaz; Soule, Jess; Phan, Ngan; Wicht, Denyce K.; Dowling, Daniel P.
作者单位：University of Massachusetts System; University of Massachusetts Boston; Suffolk University; University of California System; University of California Los Angeles; University of California System; University of California Berkeley
摘要：Sulfur is an essential element for life. Bacteria can obtain sulfur from inorganic sulfate; but in the sulfur starvation-induced response, Pseudomonads employ two- component flavin- dependent monooxygenases (TC- FMOs) from the msu and sfn operons to assimilate sulfur from environmental compounds including alkanesulfonates and dialkylsulfones. Here, we report binding studies of oxidized FMN to enzymes involved within the P. fluorescens enzymatic pathway responsible for converting dimethylsulfon...
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作者：Izzo, Maria Grazia; Russo, John; Pastore, Giorgio
作者单位：Universita Ca Foscari Venezia; International School for Advanced Studies (SISSA); Sapienza University Rome; University of Trieste
摘要：The distinctive characteristics of water, evident in its thermodynamic anomalies, have implications across disciplines from biology to geophysics. Considered a valid hypothesis to rationalize its unique properties, a liquid-liquid phase transition in water below the freezing point, in the so-called supercooled regime, has nowadays been observed in several molecular dynamics simulations and is being actively researched experimentally. The hypothesis of ferroelectric phase transition in supercoo...
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作者：Kushnir, Yochanan; Stein, Mordechai; Biasutti, Michela; Kiro, Yael; Goldsmith, Yonaton; Goldstein, Steven L.
作者单位：Columbia University; Hebrew University of Jerusalem; Geological Survey Israel; Weizmann Institute of Science; Columbia University
摘要：The mechanisms underlying the current greenhouse gas (GHG) forced decline in Mediterranean rainfall remain a matter of debate. To inform our understanding of the current and projected drying, we examined extended arid intervals in the late Quaternary, Eastern Mediterranean (EM) Levant indicated by substantial salt deposits in a Dead Sea sediment core covering the past 220 kyr. These arid events occurred during interglacials, when the Earth was at perihelion to the sun in boreal fall and during...
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作者：Nestor, Michael W.; Cordova, France; Pines, Darryll; Merfeld, Danielle; Griffiths, Jennifer; Mcnutt, Marcia
作者单位：National Academies of Sciences, Engineering & Medicine; University System of Maryland; University of Maryland College Park
