47期

最新文章

• MurA- catalyzed synthesis of 5-enolpyruvylshikimate-3-phosphate confers tolerance in AI翻译
  作者：Caygill, Samuel; Koecher, Thomas; Dolan, Liam
  作者单位：Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI); University of Oxford; Vienna Biocenter (VBC)
  摘要：Glyphosate is a broad- spectrum herbicide that kills most vascular plant weeds but is ineffective against many bryophytes. Glyphosate competitively inhibits the enolpyruvyl transferase enzyme 5- enolpyruvylshikimate-3- phosphate synthase (EPSPS). EPSPS catalyzes the production of 5- enolpyruvylshikimate-3- phosphate (EPSP)-an intermediate in the shikimate pathway-from shikimate-3- phosphate (S3P) and phosphoenolpyruvate (PEP) substrates. Here, we show that Marchantia polymorpha mutants with lo...
• Clathrin-independent endocytosis of ubiquitinated cargos (vol 102, pg 2760, 2005) AI翻译
  作者：Sigismund, Sara; Woelk, Tanja; Puri, Claudia; Maspero, Elena; Tacchetti, Carlo; Transidico, Pietro; Di Fiore, Pier Paolo; Polo, Simona
• Modeling the velocity of evolving lineages and predicting dispersal patterns AI翻译
  作者：Bastide, Paul; Rocu, Pauline; Wirtz, Johannes; Hassler, Gabriel W.; Chevenet, Francois; Fargette, Denis; Suchard, Marc A.; Dellicour, Simon; Lemey, Philippe; Guindon, Stephane
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Information Sciences & Technologies (INS2I); Universite Paul-Valery; Universite Perpignan Via Domitia; Universite de Montpellier; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier; RAND Corporation; Rand Health; Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; CIRAD; INRAE; Institut de Recherche pour le Developpement (IRD); University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Universite Libre de Bruxelles; KU Leuven
  摘要：Accurate estimation of the dispersal velocity or speed of evolving organisms is no mean feat. In fact, existing probabilistic models in phylogeography or spatial population genetics generally do not provide an adequate framework to define velocity in a relevant manner. For instance, the very concept of instantaneous speed simply does not exist under one of the most popular approaches that models the evolution of spatial coordinates as Brownian trajectories running along a phylogeny. Here, we i...
• Adsorbed microdroplets are mobile at the nanoscale AI翻译
  作者：Rana, Ashutosh; Clarke, Thomas B.; Nguyen, James H.; Dick, Jeffrey E.
  作者单位：Purdue University System; Purdue University; Purdue University System; Purdue University
  摘要：The extraordinary chemistry of microdroplets has reshaped how we as a community think about reactivity near multiphase boundaries. Even though interesting physico- chemical properties of microdroplets have been reported, sessile droplets' inherent mobility, which has been implicated as a driving force for curious chemistry, has not been well established. This paper seeks to answer the question: Can adsorbed microdroplets be mobile at the nanoscale? This is a tantalizing question, as almost no ...
• Reply to Loh: Exploratory mediational insights regarding the link between parents' perceptions of socioeconomic mobility and opportunity hoarding AI翻译
  作者：Silverman, David M.; Hernandez, Ivan A.; Schneider, Marlis; Ryan, Rebecca M.; Kalil, Ariel; Destin, Mesmin
  作者单位：Northwestern University; California State University System; California Polytechnic State University San Luis Obispo; Norwegian School of Economics (NHH); Georgetown University; University of Chicago
• S- adenosyl- L- methionine is the unexpected methyl donor for the methylation of mercury by the membrane- associated HgcAB complex AI翻译
  作者：Zheng, Kaiyuan; Rush, Katherine W.; Date, Swapneeta S.; Johs, Alexander; Parks, Jerry M.; Fleischhacker, Angela S.; Abernathy, Macon J.; Sarangi, Ritimukta; Ragsdale, Stephen W.
  作者单位：University of Michigan System; University of Michigan; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; University of Virginia; Auburn University System; Auburn University; Vanderbilt University
  摘要：Mercury (Hg) is a heavy metal that exhibits high biological toxicity. Monomethylmercury and dimethylmercury are neurotoxins and a significant environmental concern as they bioaccumulate and biomagnify within the aquatic food web. Microbial Hg methylation involves two proteins, HgcA and HgcB. Here, we show that HgcA and HgcB can be heterologously coexpressed, and the HgcAB complex can be purified. We demonstrated that HgcA is a membrane- associated cobalamin- dependent methyltransferase and Hgc...
• Targeted degradation of Pin1 by protein- destabilizing compounds AI翻译
  作者：Alboreggia, Giulia; Udompholkul, Parima; Rodriguez, Isaac; Blaha, Gregor; Pellecchia, Maurizio
  作者单位：University of California System; University of California Riverside; University of California System; University of California Riverside
  摘要：The concept of targeted protein degradation is at the forefront of modern drug discovery, which aims to eliminate disease- causing proteins using specific molecules. In this paper, we explored the idea to design protein degraders based on the section of ligands that cause protein destabilization, hence that facilitate the cellular breakdown of the target. Our studies present covalent agents targeting Pin1, a cis-trans prolyl isomerase that plays a crucial role in tumorigenesis. Our design stra...
• A magnetohydrodynamic mechanism for the formation of solar polar vortices AI翻译
  作者：Dikpati, Mausumi; Raphaldini, Breno; Mcintosh, Scott W.; Korsos, Marianna B.; Guerrero, Gustavo A.; Gilman, Peter A.
  作者单位：National Center Atmospheric Research (NCAR) - USA; University of Sheffield; Universidade Federal de Minas Gerais
  摘要：rocky planets to Jupiter- and Saturn- like gas giant planets. Very little is known about their existence or dynamics on the Sun. What should be expected near the Sun's pole for the upcoming solar multi- viewpoint and polar missions? Here, we report the magnetohydrodynamic (MHD) nonlinear simulations for the formation and evolution of solar polar vortices using a near- surface MHD shallow- water model. Our findings indicate that the rush to the poles, the migration of magnetic fields toward the...
• Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum AI翻译
  作者：Giossi, Cristina; Bahuguna, Jyotika; Rubin, Jonathan E.; Verstynen, Timothy; Vich, Catalina
  作者单位：Universitat de les Illes Balears; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Carnegie Mellon University; Carnegie Mellon University
  摘要：Reactive inhibitory control is crucial for survival. Traditionally, this control in mammals was attributed solely to the hyperdirect pathway, with cortical control signals flowing unidirectionally from the subthalamic nucleus (STN) to basal ganglia output regions. Yet recent findings have put this model into question, suggesting that the STN is assisted in stopping actions through ascending control signals to the striatum mediated by the external globus pallidus (GPe). Here, we investigate thi...
• Loss of XIST lncRNA unlocks stemness and cellular plasticity in ovarian cancer AI翻译
  作者：Naciri, Ikrame; Liang, Minzhi; Yang, Ying; Karner, Heather; Lin, Benjamin; Ludena, Maria De Lourdes Andrade; Hanse, Eric A.; Lebron, Alfredo; Razorenova, Olga, V; Nicholas, Dequina; Kong, Mei; Sun, Sha
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of Notre Dame; University of Notre Dame; University of California System; University of California San Francisco; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham
  摘要：Plasticity, a key hallmark of cancer, enables cells to transition into different states, driving tumor heterogeneity. This cellular plasticity is associated with cancer progression, treatment resistance, and relapse. Cancer stem cells (CSCs) play a central role in this process, yet the molecular factors underlying cancer cell stemness remain poorly understood. In this study, we explored the role of XIST (X- inactive specific transcript) long noncoding RNA in ovarian cancer stemness and plastic...