47期

最新文章

• Self- sacrificing and self- supporting biomass carbon anode- assisted water electrolysis for low- cost hydrogen production AI翻译
  作者：Huang, Yuming; Zhou, Wei; Xie, Liang; Meng, Xiaoxiao; Li, Junfeng; Gao, Jihui; Zhao, Guangbo; Qin, Yukun
  作者单位：Harbin Institute of Technology
  摘要：Electrooxidation of renewable and CO2- neutral biomass for low- cost hydrogen production is a promising and green technology. Various biomass platform molecules (BPMs) oxidation assisted hydrogen production technologies have obtained noticeable progress. However, BPMs anodic oxidation is highly dependent on electrocatalysts, and the oxidation mechanism is ambiguous. Meanwhile, the complexity and insolubility of natural biomass severely constrain the efficient utilization of biomass resources. ...
• A closed- loop modular multiorgan- on- chips platform for self- sustaining and tightly controlled oxygenation AI翻译
  作者：Jiang, Nan; Ying, Guoliang; Yin, Yixia; Guo, Jie; Lozada, Jorge; Padilla, Alejandra Valdivia; Gomez, Ameyalli; de Melo, Bruna Alice Gomes; Mestre, Francisco Lugo; Gansevoort, Merel; Palumbo, Marcello; Cala, Noemi; Garciamendez-Mijares, Carlos Ezio; Kim, Ge-Ah; Takayama, Shuichi; Gerhard-Herman, Marie Denis; Zhang, Yu Shrike
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; University System of Georgia; Georgia Institute of Technology; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Sichuan University
  摘要：To mimic physiological microenvironments in organ- on- a- chip systems, physiologically relevant parameters are required to precisely access drug metabolism. Oxygen level is a critical microenvironmental parameter to maintain cellular or tissue functions and modulate their behaviors. Current organ- on- a- chip setups are oftentimes subjected to the ambient incubator oxygen level at 21%, which is higher than most if not all physiological oxygen concentrations. Additionally, the physiological ox...
• Monocytes give rise to Langerhans cells that preferentially migrate to lymph nodes at steady state AI翻译
  作者：Raquer, Hayley M.; Alfaro, Raul A. Maqueda --; Saravanan, Sanjana; Hornero, Rebeca Arroyo; Clausen, Bjoern E.; Blackmore, Andres Gottfried --; Idoyaga, Juliana
  作者单位：Stanford University; Stanford University; University of California System; University of California San Diego; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; University of California System; University of California San Diego; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; University of California System; University of California San Diego
  摘要：Current evidence suggests that ontogeny may account for the functional heterogeneity of some tissue macrophages, but not others. Here, we asked whether developmental origin drives different functions of skin Langerhans cells (LCs), an embryo- derived mononuclear phagocyte with features of both tissue macrophages and dendritic cells. Using time- course analyses, bone marrow chimeras, and fate tracing models, we found that the complete elimination of embryo- derived LCs at steady state results i...
• Light-dependent switching between two flagellar beating states selects versatile phototaxis strategies in microswimmers AI翻译
  作者：Tsang, Alan C. H.; Riedel-Kruse, Ingmar H.
  作者单位：University of Hong Kong; University of Arizona; University of Arizona; University of Arizona; University of Arizona
  摘要：Microorganisms have evolved sophisticated sensor-actuator circuits to perform taxis in response to various environmental stimuli. How any given circuit can select between different taxis responses in noisy vs. saturated stimuli conditions is unclear. Here, we investigate how Euglena gracilis can select between positive vs. negative phototaxis under low vs. high light intensities, respectively. We propose three general selection mechanisms for phototactic microswimmers, and biophysical modeling...
• Targeted engineering of camelina and pennycress seeds for ultrahigh accumulation of acetyl- TAG AI翻译
  作者：Alkotami, Linah; White, Dexter J.; Schuler, Kathleen M.; Esfahanian, Maliheh; Jarvis, Brice A.; Paulson, Andrew E.; Koley, Somnath; Kang, Jinling; Lu, Chaofu; Allen, Doug K.; Lee, Young-Jin; Sedbrook, John C.; Durrett, Timothy P.
  作者单位：Kansas State University; Kansas State University; Illinois State University; Iowa State University; Donald Danforth Plant Science Center; Montana State University System; Montana State University Bozeman; United States Department of Agriculture (USDA)
  摘要：Acetyl- TAG (3- acetyl- 1,2- diacylglycerol), unique triacylglycerols (TAG) possessing an acetate group at the sn-3 position, exhibit valuable properties, such as reduced viscosity and freezing points. Previous attempts to engineer acetyl- TAG production in oilseed crops did not achieve the high levels found in naturally producing Euonymus seeds. Here, we demonstrate the successful generation of camelina and pennycress transgenic lines accumulating nearly pure acetyl- TAG at 93 mol% and 98 mol...
• The glucocorticoid receptor potentiates aldosterone- induced transcription by the mineralocorticoid receptor AI翻译
  作者：Johnson, Thomas A.; Fettweis, Gregory; Wagh, Kaustubh; Heras, Diego Ceacero -; Krishnamurthy, Manan; de Medina, Fermin Sanchez; Martinez-Augustin, Olga; Upadhyaya, Arpita; Hager, Gordon L.; de la Rosa, Diego Alvarez
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University System of Maryland; University of Maryland College Park; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University of Granada; University of Granada; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University System of Maryland; University of Maryland College Park; Universidad de la Laguna; Universidad de la Laguna
  摘要：The glucocorticoid , mineralocorticoid receptors (GR and MR, respectively) have distinct, yet overlapping physiological and pathophysiological functions. There are indi- cations that both receptors interact functionally and physically, but the precise role of this interdependence is poorly understood. Here, we analyzed the impact of GR coex- pression on MR genome- wide- wide transcriptional responses and chromatin binding upon activation by aldosterone and glucocorticoids, both physiological l...
• Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease (vol 119, e2210779119, 2022) AI翻译
  作者：Metaferia, Belhu; Cellmer, Troy; Dunkelberger, Emily B.; Li, Quan; Henry, Eric R.; Hofrichter, James; Staton, Dwayne; Hsieh, Matthew M.; Conrey, Anna K.; Tisdale, John F.; Chatterjee, Arnab K.; Thein, Swee Lay; Eaton, William A.
• Microtubule poleward flux as a target for modifying chromosome segregation errors AI翻译
  作者：Risteski, Patrik; Martincic, Jelena; Jagric, Mihaela; Tintor, Erna; Petelinec, Ana; Tolic, Iva M.
  作者单位：Rudjer Boskovic Institute
  摘要：Cancer cells often display errors in chromosome segregation, some of which result from improper chromosome alignment at the spindle midplane. Chromosome alignment is facilitated by different rates of microtubule poleward flux between sister kinetochore fibers. However, the role of the poleward flux in supporting mitotic fidelity remains unknown. Here, we introduce the hypothesis that the finely tuned poleward flux safeguards against lagging chromosomes and micronuclei at mitotic exit by promot...
• Direct parallel electrosynthesis of high- value chemicals from atmospheric components on symmetry- breaking indium sites AI翻译
  作者：Sun, Yuntong; Dai, Liming; Sui, Nicole L. D.; Li, Yinghao; Tian, Meng; Duan, Jingjing; Chen, Sheng; Lee, Jong-Min
  作者单位：Nanyang Technological University; Nanjing University of Science & Technology; Danish Hydraulic Institute (DHI); Nanyang Technological University; Nanjing University of Science & Technology
  摘要：To tackle significant environmental and energy challenges from increased greenhouse gas emissions in the atmosphere, we propose a method that synergistically combines cost- efficient integrated systems with parallel catalysis to produce high- value chemicals from CO2, NO, and other gases. We employed asymmetrically stretched InO5S with symmetry- breaking indium sites as a highly efficient trifunctional catalysts for NO reduction, CO2 reduction, and O2 reduction. Mechanistic studies reveal that...
• Extending the G1 phase improves the production of lipophilic compounds in yeast by boosting enzyme expression and increasing cell size AI翻译
  作者：Hao, He; Yao, Mingdong; Wang, Ying; Zhang, Chenglong; Liu, Zihe; Nielsen, Jens; Shi, Shuobo; Xiao, Wenhai; Yuan, Yingjin
  作者单位：Tianjin University; Tianjin University; Tianjin University; Beijing University of Chemical Technology; Chalmers University of Technology; Tianjin University; Tianjin University
  摘要：Cell phase engineering can significantly impact protein synthesis and cell size, potentially enhancing the production of lipophilic products. This study investigated the impact of G1 phase extension on resource allocation, metabolic functions, and the unfolded protein response (UPR) in yeast, along with the potential for enhancing the production of lipophilic compounds. In brief, the regulation of the G1 phase was achieved by deleting CLN3 (G1 cyclin) in various yeast strains. This modificatio...