47期

最新文章

• Observation of Thouless pumping of light in quasiperiodic photonic crystals AI翻译
  作者：Yang, Kai; Fu, Qidong; Prates, Henrique C.; Wang, Peng; Kartashov, Yaroslav, V; Konotop, Vladimir V.; Ye, Fangwei
  作者单位：Shanghai Jiao Tong University; Universidade de Lisboa; Universidade de Lisboa; Russian Academy of Sciences; Institute of Spectroscopy
  摘要：Topological transport is determined by global properties of physical media where it occurs and is characterized by quantized amounts of adiabatically transported quantities. Discovered for periodic potential, it was also explored in disordered and discrete quasiperiodic systems. Here, we report on experimental observation of pumping of a light beam in a genuinely continuous incommensurate photorefractive quasicrystal emulated by its periodic approximants. We observe a universal character of th...
• Tai/NCOA2 suppresses the Hedgehog pathway by directly targeting the transcription factor Ci/GLI AI翻译
  作者：Yu, Xuan; Wang, Xinyu; Ma, Kaize; Gao, Dongqing; Deng, Yanran; Zhou, Dafa; Ding, Wenhao; Zhao, Yunhe; Liu, Qingxin; Zhou, Zizhang
  作者单位：Shandong Agricultural University; Jiangxi Normal University
  摘要：The Hedgehog (Hh) pathway plays diverse roles in cellular processes by activating the transcription factor Cubitus interruptus (Ci). Abnormal regulation of this pathway has been linked to various human diseases. While previous studies have focused on how Ci is regulated in the cytoplasm, the control of nuclear Ci remains poorly understood. In this study, we have found that the transcriptional cofactor Taiman (Tai) functions as an inhibitor of the Hh pathway. Tai interferes with the response of...
• Mediator kinase inhibitors suppress triple- negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors AI翻译
  作者：Ding, Xiaokai; Liang, Jiaxin; Sharko, Amanda C.; Hilimire, Thomas A.; Li, Jing; Loskutov, Jurgen; Mack, Zachary T.; Ji, Hao; Schools, Gary P.; Cai, Chao; Pugacheva, Elena N.; Chen, Mengqian; Roninson, Igor B.; Broude, Eugenia V.
  作者单位：University of South Carolina System; University of South Carolina Columbia; West Virginia University; University of South Carolina System; University of South Carolina Columbia
  摘要：Triple- negative breast cancers (TNBC) are treated primarily by chemotherapy and lack clinically validated therapeutic targets. In particular, inhibitors of the PI3K/AKT/mTOR pathway, abnormally activated in many breast cancers, failed to achieve clinical efficacy in TNBC due to the development of adaptive drug resistance, which is largely driven by the transcriptomic plasticity of TNBC. Expression of CDK8/19 Mediator kinases that control transcriptional reprogramming correlates with relapse- ...
• Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice AI翻译
  作者：Trigg, Natalie; Schjenken, John E.; Martin, Jacinta H.; Skerrett-Byrne, David A.; Smyth, Shannon P.; Bernstein, Ilana R.; Anderson, Amanda L.; Stanger, Simone J.; Simpson, Ewan N. A.; Tomar, Archana; Teperino, Raffaele; Conine, Colin C.; De Iuliis, Geoffry N.; Roman, Shaun D.; Bromfield, Elizabeth G.; Dun, Matthew D.; Eamens, Andrew L.; Nixon, Brett
  作者单位：University of Newcastle; University of Newcastle; Hunter Medical Research Institute; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; German Center for Diabetes Research (DZD); University of Melbourne; University of Melbourne; University of Newcastle; Hunter Medical Research Institute; University of Newcastle; University of the Sunshine Coast
  摘要：Forecasted increases in the prevalence and severity of extreme weather events accompanying changes in climatic behavior pose potential risk to the reproductive capacity of humans and animals of ecological and agricultural significance. While several studies have revealed that heat stress induced by challenges such as testicular insulation can elicit a marked negative effect on the male reproductive system, and particularly the production of spermatozoa, less is known about the immediate impact...
• Chirality-induced phonon spin selectivity by elastic spin-orbit interaction AI翻译
  作者：Yang, Chenwen; Ren, Jie
  作者单位：Tongji University
  摘要：Spin and orbital degrees of freedom are crucial in not only fundamental particles but also classical waves such as optical systems, wherein the spin-orbit interaction (SOI) of light provides new perspectives for manipulating electromagnetic waves. Elastic waves possess similar spin angular momentum (SAM) and orbital angular momentum (OAM). However, the elastic counterpart of SOI remains unexplored, even for ubiquitous elastic waveguides (WG). Here, we demonstrate the existence of elastic SOI i...
• Hematite U-Pb dating of Snowball Earth meltwater events AI翻译
  作者：Courtney-Davies, Liam; Flowers, Rebecca M.; Siddoway, Christine S.; Hart, Adrian Tasistro-; Macdonald, Francis A.
  作者单位：University of Colorado System; University of Colorado Boulder; Colorado College; University of California System; University of California Santa Barbara; University of California System; University of California Berkeley
  摘要：The Snowball Earth hypothesis predicts global ice cover; however, previous descriptions of Cryogenian (720-635 Ma) glacial deposits are limited to continental margins and shallow marine basins. The Tavakaiv (Tava) sandstone injectites and ridges in Colorado, USA, preserve a rare terrestrial record of Cryogenian low-latitude glaciation. Injectites, ridges, and chemically weathered crystalline rock display features characteristic of fluidization and pervasive deformation in a subglacial environm...