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作者：Majer, Johann M.; Columbus, Simon; Schweinsberg, Martin
作者单位：University of Hildesheim; Massachusetts Institute of Technology (MIT); European School of Management & Technology
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作者：Ravindranathan, Ramya; Somuncu, Ozge; da Costa, Alexandre Andre B. A.; Mukkavalli, Sirisha; Lamarre, Benjamin P.; Nguyen, Huy; Grochala, Carter; Jiao, Yuqing; Liu, Joyce; Kochupurakkal, Bose; Parmar, Kalindi; Shapiro, Geoffrey I.; D'Andrea, Alan D.
作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Poly (ADP- ribose) glycohydrolase (PARG) is a dePARylating enzyme which promotes DNA repair by removal of poly (ADP- ribose) (PAR) from PARylated proteins. Loss or inhibition of PARG results in replication stress and sensitizes cancer cells to DNA- damaging agents. PARG inhibitors are now undergoing clinical development for patients having tumors with homologous recombination deficiency (HRD), such as cancer patients with germline or somatic BRCA1/2- mutations. PARP inhibitors kill BRCA- defic...
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作者：Feng, Jie; Qi, Jintao; Zhang, Hanxu; Chen, Siyu; Zhu, Mingyang; Hu, Xichen; Xu, Hao; Fu, Changbo; Wang, Xu; Chen, Liming; Zhang, Jie
作者单位：Shanghai Jiao Tong University; Chinese Academy of Engineering Physics; Chinese Academy of Sciences; Fudan University; Chinese Academy of Sciences; Shanghai Jiao Tong University; Shanghai Jiao Tong University
摘要：We demonstrate an approach successfully measuring very small nuclear isomeric excitation cross sections (on the order of 10 to 100 picobarns) via laser-cluster interaction. The interaction between an intense laser pulse and Kr atomic clusters generates a high-temperature and high-density plasma ball in which nuclear excitations are facilitated by inelastic electron scattering. The electron temperature reaches several hundred keV (corresponding to 109 K), similar to a stellar environment. The v...
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作者：Huo, Jing; Xu, Tianqi; Li, Qi; Polat, Mahiber; Kumar, Sandeep; Zhang, Xiaoqian; Leifer, Andrew M.; Wen, Quan
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shandong Second Medical University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Princeton University; Princeton University
摘要：Animal behavior is organized into nested temporal patterns that span multiple timescales. This behavior hierarchy is believed to arise from a hierarchical neural architecture: Neurons near the top of the hierarchy are involved in planning, selecting, initiating, and maintaining motor programs, whereas those near the bottom of the hierarchy act in concert to produce fine spatiotemporal motor activity. In Caenorhabditis elegans, behavior on a long timescale emerges from ordered and flexible tran...
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作者：Lei, Xiaoyi; Xiao, Ruipei; Chen, Zhe; Ren, Jie; Zhao, Wenli; Tang, Wenting; Wen, Kang; Zhu, Yihan; Li, Xinru; Ouyang, Suidong; Xu, Abai; Hu, Yu; Bi, Enguang
作者单位：Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; Guangdong Medical University
摘要：The importance of CD4+T cells in cancer immunotherapy has gained increasing recognition. Particularly, a specific subset of CD4+ T cells coexpressing the T helper type 1 (Th1) and Th17 markers has demonstrated remarkable antitumor potential. However, the underlying mechanisms governing the differentiation of these cells and their subsequent antitumor responses remain incompletely understood. Single- cell RNA sequencing (scRNA-seq) data reanalysis demonstrated the presence of Th171 cells within...
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作者：Brezovec, Bella E.; Berger, Andrew B.; Hao, Yukun A.; Lin, Albert; Ahmed, Osama M.; Pacheco, Diego A.; Thiberge, Stephan Y.; Murthy, Mala; Clandinin, Thomas R.
作者单位：Stanford University; Princeton University; University of Colorado System; University of Colorado Boulder; Stanford University; Princeton University; University of Washington; University of Washington Seattle; Harvard University; Harvard Medical School
摘要：Imaging methods that span both functional measures in living tissue and anatomical measures in fixed tissue have played critical roles in advancing our understanding of the brain. However, making direct comparisons between different imaging modalities, particularly spanning living and fixed tissue, has remained challenging. For example, comparing brain-wide neural dynamics across experiments and aligning such data to anatomical resources, such as gene expression patterns or connectomes, requir...
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作者：Legan, Andrew W.; Allan, Carson W.; Jensen, Zoe N.; Degain, Benjamin A.; Yang, Fei; Kerns, David L.; Benowitz, Kyle M.; Fabrick, Jeffrey A.; Li, Xianchun; Carriere, Yves; Matzkin, Luciano M.; Tabashnik, Bruce E.
作者单位：University of Arizona; University of Minnesota System; University of Minnesota Twin Cities; Texas A&M University System; Texas A&M University College Station; Arizona State University; United States Department of Agriculture (USDA); USDA Agricultural Research Service
摘要：Transgenic crops producing crystalline (Cry) proteins from the bacterium Bacillus thuringiensis (Bt) have been used extensively to control some major crop pests. However, many populations of the noctuid moth Helicoverpa zea, one of the most important crop pests in the United States, have evolved practical resistance to several Cry proteins including Cry1Ac. Although mutations in single genes that confer resistance to Cry proteins have been identified in lab- selected and gene- edited strains o...
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作者：Alba, Richard
作者单位：City University of New York (CUNY) System
摘要：The ethnoracial future of the United States has been framed as a demographic binary: Whites vs. people of color. The argument here is that this binary distorts by failing to take into adequate account the rapidly growing group of Americans who have been raised in mixed minority and White families, the great majority of the total mixed population. The members of this group generally have distinctive social characteristics: socioeconomic advantages compared to minorities and social integration i...
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作者：Cerbus, Rory T.; Hiratani, Ichiro; Kawaguchi, Kyogo
作者单位：RIKEN; RIKEN; RIKEN; University of Tokyo; University of Tokyo
摘要：Vertebrate development and phylogeny are intimately connected through the vertebral formula, the numerical distribution of vertebrae along the body axis into different categories such as neck and chest. A key window into this relationship is through the conserved Hox gene clusters. Hox gene expression boundaries align with vertebral boundaries, and their manipulation in model organisms often results in the transformation of one vertebral type into its neighbor, a homeotic transformation. If th...
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作者：Angabo, Sarah; Pandi, Karthikeyan; David, Keren; Steinmetz, Orit; Makkawi, Hasnaa; Farhat, Maria; Eli-Berchoer, Luba; Darawshi, Nadeem; Kawasaki, Hiromichi; Nussbaum, Gabriel
作者单位：Hebrew University of Jerusalem; Wakunaga Pharmaceutical Co., Ltd.
摘要：Porphyromonasgingivalis is a gram- negative anaerobic bacterium linked to periodontal disease. Remarkably, P. gingivalis thrives in an inflamed environment rich in activated neutrophils. Toll- like receptor 2 (TLR2) recognition is required forP. gingivalis to evade innate immune killing; however, the mechanisms through which P. gingivalis uncouples host inflammation from bactericidal activity are only partially known. Since integrin activation and alternative signaling are implicated in P. gin...
