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作者：Loomis, Rebecca J.; Lai, Yen-Ting; Sowers, Sun B.; Fisher, Brian; Derrien-Colemyn, Alexandrine; Ambrozak, David R.; Tsybovsky, Yaroslav; Crooke, Stephen N.; Latner, Donald R.; Kong, Wing-Pui; Ruckwardt, Tracy J.; Plotkin, Stanley A.; Kwong, Peter D.; Mascola, John R.; Graham, Barney S.; Hickman, Carole J.; Stewart-Jones, Guillaume B. E.
作者单位：National Institutes of Health (NIH) - USA; Centers for Disease Control & Prevention - USA; CDC National Center for Immunization & Respiratory Diseases (NCIRD); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of Pennsylvania
摘要：Mumps virus (MuV) is a highly contagious paramyxovirus that is endemic in most regions of the world and continues to cause outbreaks even in highly immunized populations. Outbreaks of mumps in countries with high measles, mumps, and rubella vaccination coverage have been attributed to waning immunity and antigenic differences between the Jeryl Lynn vaccine strain (genotype A) and circulating wild- type viruses. To obtain a subunit vaccine, we used structure- based design to engineer the mumps ...
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作者：Wu, Zhanghui; Wang, Yiran; Wu, Tielin; Wang, Yelingyi; Chen, Weipeng; Zhou, Chucheng; Ma, Ming; Zheng, Quanshui
作者单位：Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua Shenzhen International Graduate School; Tsinghua Shenzhen International Graduate School
摘要：Sliding electrical contacts are commonly applied in electrical connectors, such as conductive slip rings, pantographs, switches, and commutators. However, they suffer from several unavoidable problems caused by friction and wear, including high energy consumption, intermittent failures, limited life, and even failure disasters. In this study, we realized an ultralow- friction and long- distance wear- free state, defined as structural superlubricity (SSL), between sliding electrical interfaces ...
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作者：Loh, Wen Wei
作者单位：Maastricht University
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作者：Yang, Jingjing; Li, Wenjuan; Zhang, Zepeng; Gong, Xiaohua; Chen, Yanchao; Peng, Xiaoyu; Hu, Guosheng; Dai, Xianglong; He, Yaohui; Huang, Ying; Cao, Shiqiang; Yang, Yang; Liu, Wen
作者单位：Xiamen University; Southern University of Science & Technology; Xiamen University; Fujian Medical University
摘要：RIG- I- like receptors (RLRs)- mitochondrial antiviral signaling protein (MAVS) are crucial for type I interferon (IFN) signaling pathway and innate immune responses triggered by RNA viruses. However, the regulatory molecular mechanisms underlying RNA virus- activated type I IFN signaling pathway remain incompletely understood. Here, we found that protein arginine methyltransferase 7 (PRMT7) serves as a negative regulator of the type I IFN signaling pathway by interacting with MAVS and catalyz...
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作者：Huang, Jun; Larmore, Connor J.; Priest, Shelby J.; Xu, Ziyan; Dietrich, Fred S.; Yadav, Vikas; Magwene, Paul M.; Sun, Sheng; Heitman, Joseph
作者单位：Duke University; Duke University
摘要：While increased mutation rates typically have negative consequences in multicellular organisms, hypermutation can be advantageous for microbes adapting to the environment. Previously, we identified two hypermutator Cryptococcus neoformans clinical isolates that rapidly develop drug resistance due to transposition of a retrotransposon, Cnl1.Cnl1-mediated hypermutation is caused by a nonsense mutation in a gene encoding an RNA interference (RNAi) component, ZNF3, combined with a tremendous trans...
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作者：Li, Yuanyuan; Xu, Wenyan; Cheng, Yubao; Djenoune, Lydia; Zhuang, Chuzhi; Cox, Andrew Lee; Britto, Clemente J.; Yuan, Shiaulou; Wang, Siyuan; Sun, Zhaoxia
作者单位：Yale University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Yale University; Yale University
摘要：Axonemal dynein, the macromolecular machine that powers ciliary motility, assembles in the cytosol with the help of dynein axonemal assembly factors (DNAAFs). These DNAAFs localize in cytosolic foci thought to form via liquid-liquid phase separation. However, the functional significance of DNAAF foci formation and how the production and assembly of multiple components are so efficiently coordinated, at such enormous scale, remain unclear. Here, we unveil an axonemal dynein production and assem...
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作者：Zhang, Guoqiang; Miao, Yaqi; Song, Yuan; Wang, Liangliang; Li, Yawei; Zhu, Yuanxiang; Zhang, Wenxin; Sun, Qinmiao; Chen, Dahua
作者单位：Yunnan University; Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences
摘要：Early embryos undergo profound changes in their genomic architecture to establish the totipotent state, enabling pioneer factors to access chromatin and drive zygotic genome activation (ZGA). However, the mechanisms by which the totipotent state is established and properly interpreted by pioneer factors to allow orderly ZGA remain unknown. Here, we identify the H3.3- specific chaperone HIRA as a factor involving establishing totipotent-state chromatin in Drosophila early embryos. Through copha...
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作者：Fiorenzano, Alessandro; Storm, Petter; Sozzi, Edoardo; Bruzelius, Andreas; Corsi, Sara; Kajtez, Janko; Mudannayake, Janitha; Nelander, Jenny; Mattsson, Bengt; Akerblom, Malin; Bjorklund, Tomas; Bjorklunda, Anders; Parmar, Malin
作者单位：Lund University; Lund University
摘要：Dopaminergic (DA) neurons exhibit significant diversity characterized by differences in morphology, anatomical location, axonal projection pattern, and selective vulnerability to disease. More recently, scRNAseq has been used to map DA neuron diversity at the level of gene expression. These studies have revealed a higher than expected molecular diversity in both mouse and human DA neurons. However, whether different molecular expression profiles correlate with specific functions of different D...
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作者：Hillis, Alissandra L.; Tamir, Tigist; Perry, Grace E.; Asara, John M.; Johnson, Jared L.; Yaron, Tomer M.; Cantley, Lewis C.; White, Forest M.; Toker, Alex
作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School; Cornell University; Weill Cornell Medicine
摘要：Tyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved posttranslational modification that facilitates rapid and reversible modulation of enzyme activity, localization, or function. Despite the high abundance of tyrosine phosphorylation events detected on metabolic enzymes in high- throughput mass spectrometry- based studies, functional characterization of tyrosine phosphorylation sites has been limited to a subset of enzymes. Since tyrosine phosphorylation is dysregulate...
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作者：Maclennan, Scott A.; Sha, Jingeng; Olsen, Paul E.; Kinney, Sean T.; Chang, Clara; Fang, Yanan; Liu, Jun; Slibeck, Bennett B.; Chen, Elaine; Schoene, Blair
作者单位：University of Witwatersrand; Princeton University; Chinese Academy of Sciences; Columbia University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS
摘要：Northeast China's Early Cretaceous Yixian Formation preserves spectacular fossils that have proved extraordinarily important in testing evolutionary hypotheses involving the origin of birds and the distribution of feathers among nonavian dinosaurs. These fossils occur either flattened with soft tissue preservation (including feathers and color) in laminated lacustrine strata or as three-dimensional (3D) skeletons in life-like postures in more massive deposits. The relationships of these deposi...
