Functional alterations of the magnocellular subdivision of the visual sensory thalamus in autism

• 成果类型: Article
• 署名作者: Schelinski, Stefanie; Kauffmann, Louise; Tabas, Alejandro; Mueller-Axt, Christa; von Kriegstein, Katharina
• 署名单位: Technische Universitat Dresden; Max Planck Society; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Universite Savoie Mont Blanc; Basque Foundation for Science
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-12991
• DOI: 10.1073/pnas.2413409121
• 发表日期: 2024-11-19
• 关键词: perception; CHILDREN

摘要

The long- standing hypothesis that autism is linked to changes in the visual magnocellular system of the human brain has never been directly examined due to technological to investigate this hypothesis within the visual sensory thalamus (lateral geniculate nucleus, LGN). The LGN is a crucial component of the primary visual pathway. It is particularly suited to investigate the magnocellular visual system, because within the LGN, the magnocellular (mLGN) uniquely segregates from the parvocellular (pLGN) (BOLD) responses in the autism group compared to controls. pLGN responses were comparable across groups. The mLGN alterations were observed specifically for stimuli optimized for mLGN function, i.e., visual displays with low spatial frequency and high temporal flicker frequency. The results confirm the long- standing hypothesis of magnocellular visual system alterations in autism. They substantiate the emerging perspective that sensory processing variations are part of autism symptomatology.