Monocytes give rise to Langerhans cells that preferentially migrate to lymph nodes at steady state

• 成果类型: Article
• 署名作者: Raquer, Hayley M.; Alfaro, Raul A. Maqueda --; Saravanan, Sanjana; Hornero, Rebeca Arroyo; Clausen, Bjoern E.; Blackmore, Andres Gottfried --; Idoyaga, Juliana
• 署名单位: Stanford University; Stanford University; University of California System; University of California San Diego; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; University of California System; University of California San Diego; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; University of California System; University of California San Diego
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8557
• DOI: 10.1073/pnas.2404927121
• 发表日期: 2024-11-19
• 关键词: dermal dendritic cells; autocrine/paracrine tgf-beta-1; resident macrophages; cardiac macrophages; fetal liver; t-cells; skin; distinct; ontogeny; maintain

摘要

Current evidence suggests that ontogeny may account for the functional heterogeneity of some tissue macrophages, but not others. Here, we asked whether developmental origin drives different functions of skin Langerhans cells (LCs), an embryo- derived mononuclear phagocyte with features of both tissue macrophages and dendritic cells. Using time- course analyses, bone marrow chimeras, and fate tracing models, we found that the complete elimination of embryo- derived LCs at steady state results in their repopulation from circulating monocytes. However, monocyte- derived LCs inefficiently replenished the epidermal niche. Instead, these cells preferentially migrated to skin- draining lymph nodes. Mechanistically, we show that the enhanced migratory capability of monocyte- derived LCs is associated with higher expression of CD207/ Langerin, a C- type lectin involved in the capture of skin microbes. Our data demonstrate that ontogeny plays a role in the migratory behavior of epidermal LCs.