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作者：Graham, Todd R.
作者单位：Vanderbilt University; Vanderbilt University
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作者：Garbett, Krassimira; Tosun, Baris; Lopez, Jaybree M.; Smith, Cassandra M.; Honkanen, Kelly; Sando, Richard C.
作者单位：Vanderbilt University
摘要：Combinatorial networks of cell adhesion molecules and cell surface receptors drive fundamental aspects of neural circuit establishment and function. However, the intracellular signals orchestrated by these cell surface complexes remain less understood. Here, we report that the G alpha 12/13 pathway lies downstream of several GPCRs with critical synaptic functions. Impairment of the G alpha 12/13 pathway in postnatal hippocampal neurons diminishes inhibitory inputs without altering neuronal mor...
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作者：Muetter, Malte; Angst, Daniel C.; Regoes, Roland R.; Bonhoeffer, Sebastian
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：The issue of antibiotic resistance is a critical concern for public health, prompting numerous investigations into the impact of treatment strategies on preventing or slowing down the emergence of resistance. While existing studies have predominantly focused on chromosomal resistance mutations, the consequences of often clinically more relevant plasmid-conferred resistance remain insufficiently explored. To address this gap, we conducted three extensive in vitro experiments utilizing a liquid-...
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作者：Detar, Rachael A.; Chustecki, Joanna M.; Martinez-Hottovy, Ana; Ceriotti, Luis Federico; Broz, Amanda K.; Lou, Xiaorui; Sanchez-Puerta, M. Virginia; Elowsky, Christian; Christensen, Alan C.; Sloan, Daniel B.
作者单位：Colorado State University System; Colorado State University Fort Collins; University of Nebraska System; University of Nebraska Lincoln; University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University Nacional Cuyo Mendoza; University of Nebraska System; University of Nebraska Lincoln
摘要：Eukaryotic nuclear genomes often encode distinct sets of translation machinery for function in the cytosol vs. organelles (mitochondria and plastids). This raises questions about why multiple translation systems are maintained even though they are capable of comparable functions and whether they evolve differently depending on the compartment where they operate. These questions are particularly interesting in plants because is often dual- targeted to the plastids and mitochondria. These organe...
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作者：Macias, Luis E. Ortuno; Jimenez-Angeles, Felipe; Marmorstein, Jason G.; Wang, Yiming; Crane, Stephen A.; Surabh, K. T.; Sun, Pan; Sapkota, Bikash; Hummingbird, Eshe; Jung, Woojin; Qiao, Baofu; Lee, Daeyeon; Dmochowski, Ivan J.; Messinger, Robert J.; Schlossman, Mark L.; Nunez, Cesar de la Fuente; Radhakrishnan, Ravi; Petersson, E. James; de la Cruz, Monica Olvera; Bu, Wei; Bera, Mrinal; Lin, Binhua; Tu, Raymond S.; Stebe, Kathleen J.; Maldarelli, Charles
作者单位：City University of New York (CUNY) System; City College of New York (CUNY); Northwestern University; University of Pennsylvania; University of Pennsylvania; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Chicago
摘要：Rare earth elements (REEs) are critical materials to modern technologies. They are obtained by selective separation from mining feedstocks consisting of mixtures of their trivalent cation. We are developing an all-aqueous, bioinspired, interfacial separation using peptides as amphiphilic molecular extractants. Lanthanide binding tags (LBTs) are amphiphilic peptide sequences based on the EF-hand metal binding loops of calcium-binding proteins which complex selectively REEs. We study LBTs optimi...
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作者：Sato, Masato; Dieckmann, Ulf; Sasaki, Akira
作者单位：Graduate University for Advanced Studies - Japan; National Institute of Advanced Industrial Science & Technology (AIST); Okinawa Institute of Science & Technology Graduate University; Graduate University for Advanced Studies - Japan; International Institute for Applied Systems Analysis (IIASA)
摘要：The epidemiology and evolution of diseases unfold in populations that are rarely homogeneous. Instead, hosts infected by pathogens often form metapopulations, in which local populations connected by the movement of hosts experience different demographic and epidemiological conditions. Here, we develop a general theory of the evolution of pathogens in heterogeneous metapopulations. We reveal the following key insights into the evolution of pathogen virulence and infectiousness: (1) When the mob...
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作者：Carey, John
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作者：Constable, Sandii; Ott, Carolyn M.; Lemire, Andrew L.; White, Kevin; Xun, Yu; Lim, Amin; Lippincott-Schwartz, Jennifer; Mukhopadhyay, Saikat
作者单位：University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
摘要：Brain neurons utilize the primary cilium as a privileged compartment to detect and respond to extracellular ligands such as Sonic hedgehog (SHH). However, cilia in cerebellar granule cell (GC) neurons disassemble during differentiation through ultrastructurally unique intermediates, a process we refer to as cilia deconstruction. In addition, mature neurons do not reciliate despite having docked centrioles. Here, we identify molecular changes that accompany cilia deconstruction and centriole do...
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作者：Furtado, Jessica; Geraldo, Luiz Henrique; Leser, Felipe Saceanu; Bartkowiak, Bartlomiej; Poulet, Mathilde; Park, Hyojin; Robinson, Mark; Pibouin-Fragner, Laurence; Eichmann, Anne; Boye, Kevin
作者单位：Yale University; Yale University; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Yale University; Yale University
摘要：The integrity of the blood-retina barrier (BRB) is crucial for phototransduction and vision, by tightly restricting transport of molecules between the blood and surrounding neuronal cells. Breakdown of the BRB leads to the development of retinal diseases. Here, we show that Netrin- 1/Unc5b and Norrin/Lrp5 signaling establish a zonated endothelial cell gene expression program that controls BRB integrity. Using single- cell RNA sequencing (scRNA- seq) of postnatal BRB- competent mouse retina end...
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作者：Anand, Satyam; Ma, Xiaolei; Guo, Shuo; Martiniani, Stefano; Cheng, Xiang
作者单位：New York University; New York University; University of Minnesota System; University of Minnesota Twin Cities; New York University
摘要：Randomly moving active particles can be herded into directed motion by asymmetric geometric structures. Although such a rectification process has been extensively studied due to its fundamental, biological, and technological relevance, a comprehensive understanding of active matter rectification based on single particle dynamics remains elusive. Here, by combining experiments, simulations, and theory, we study the directed transport and energetics of swimming bacteria navigating through funnel...
