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作者：Sinha, Abhipsa; Saini, Krishan Kumar; Chandramouli, Aakash; Tripathi, Kiran; Khan, Muqtada Ali; Satrusal, Saumya Ranjan; Verma, Ayushi; Mandal, Biswajit; Rai, Priyanka; Meena, Sanjeev; Nengroo, Mushtaq Ahmad; Singh, Manish Pratap; Bhushan, Namratha Shashi; Vasudevan, Madavan; Singhai, Atin; Singh, Kulranjan; Mishra, Anand Kumar; Kamat, Siddhesh S.; Datta, Dipak
作者单位：Council of Scientific & Industrial Research (CSIR) - India; CSIR - Central Drug Research Institute (CDRI); Academy of Scientific & Innovative Research (AcSIR); Indian Institute of Science Education & Research (IISER) Pune; King George's Medical University; King George's Medical University
摘要：Triple- negative breast cancer (TNBC) has profound unmet medical need globally for its devastating clinical outcome associated with rapid metastasis and lack of targeted therapies. Recently, lipid metabolic reprogramming especially fatty acid oxidation (FAO) has emerged as a major driver of breast cancer metastasis. Analyzing the expression of major FAO regulatory genes in breast cancer, we found selective overexpression of acyl-CoA synthetase 4 (ACSL4) in TNBC, which is primarily attributed t...
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作者：Fiorenza, Evan A.; Abu, Nur; Feeney, William E.; Limbong, Steven R.; Freimark, Claire B.; Jompa, Jamaluddin; Harvell, C. Drew; Lamb, Joleah B.
作者单位：University of California System; University of California Irvine; Universitas Muhammadiyah Sorong; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Universitas Hasanuddin; Cornell University
摘要：Seaweed farming comprises over half of global coastal and marine aquaculture production by mass; however, the future of the industry is increasingly threatened by disease outbreaks. Nature-based solutions provided by enhancing functions of coinciding species or ecosystems offer an opportunity to increase yields by reducing disease outbreaks while conserving biodiversity. Seagrass ecosystems can reduce the abundance of marine bacterial pathogens, although it remains unknown whether this service...
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作者：Vaudano, Alexandre Pierre; Schwager, Francoise; Gotta, Monica; Barbieri, Sofia
作者单位：University of Geneva
摘要：Proteins become asymmetrically distributed in the one- cell Caenorhabditis elegans embryo thanks to reaction-diffusion mechanisms that are often entangled in complex feedback loops. Cortical polarity drives the enrichment of the RNA- binding proteins MEX-5 and MEX-6 in the anterior cytoplasm through concentration gradients. MEX-5 and MEX-6 promote the patterning of other cytoplasmic factors, including that of the anteriorly enriched mitotic polo- like kinase PLK-1, but also contribute to prope...
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作者：Yeoh, Zoe C.; Meagher, Jennifer L.; Kang, Chia-Yu; Bieniasz, Paul D.; Smith, Janet L.; Ohi, Melanie D.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Rockefeller University; Howard Hughes Medical Institute; University of Michigan System; University of Michigan
摘要：Detecting viral infection is a key role of the innate immune system. The genomes of some RNA viruses have a high CpG dinucleotide content relative to most vertebrate cell RNAs, making CpGs a molecular marker of infection. The human zinc- finger antiviral protein (ZAP) recognizes CpG, mediates clearance of the foreign CpG-rich RNA, and causes attenuation of CpG-rich RNA viruses. While ZAP binds RNA, it lacks enzymatic activity that might be responsible for RNA degradation and thus requires inte...
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作者：Rees-Baylis, Ella; Pen, Ida; Kreider, Jan J.
作者单位：University of Groningen; University of Bern
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作者：Syed, Adnan K.; Baral, Rishika; Van Vlack, Erik R.; Gil-Marques, Maria Luisa; Lenhart, Taliesin; Hooper, David C.; Kahne, Daniel; Losick, Richard; Bradshaw, Niels
作者单位：Harvard University; Brandeis University; Harvard University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Cincinnati Children's Hospital Medical Center
摘要：The bacterial pathogen Staphylococcus aureus forms multicellular communities known as biofilms in which cells are held together by an extracellular matrix principally composed of repurposed cytoplasmic proteins and extracellular DNA. These biofilms assemble during infections or under laboratory conditions by growth on medium containing glucose, but the intracellular signal for biofilm formation and its downstream targets were unknown. Here, we present evidence that biofilm formation is trigger...
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作者：Begley, Matthew; Aragon, Mahira; Baker, Richard W.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：Adaptor protein complex- 3 (AP- 3) mediates cargo sorting from endosomes to lysosomes and lysosome- related organelles. Recently, it was shown that AP- 3 adopts a constitutively open conformation compared to the related AP- 1 and AP- 2 coat complexes, which are inactive until undergoing large conformational changes upon membrane recruitment. How AP- 3 is regulated is therefore an open question. To understand the mechanism of AP- 3 membrane recruitment and activation, we reconstituted human AP-...
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作者：Tarasovetc, Ekaterina, V; Sissoko, Gunter B.; Maiorov, Aleksandr; Mukhina, Anna S.; Ataullakhanov, Fazoil I.; Cheeseman, Iain M.; Grishchuk, Ekaterina L.
作者单位：University of Pennsylvania; Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT)
摘要：Macromolecular assembly depends on tightly regulated pairwise binding interactions that are selectively favored at assembly sites while being disfavored in the soluble phase. This selective control can arise due to molecular density- enhanced binding, as recently found for the kinetochore scaffold protein CENP- T. When clustered, but the underlying molecular basis remains elusive. Here, we use quantitative in vitro assays to reveal two distinct mechanisms driving this behavior. First, Ndc80 bi...
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作者：Yi, Shengzhu; Hong, Zening; Ma, Zhongjie; Zhou, Chao; Jiang, Miao; Huang, Xiang; Huang, Mingjun; Aya, Satoshi; Zhang, Rui; Wei, Qi-Huo
作者单位：Southern University of Science & Technology; South China University of Technology; South China University of Technology; Southern University of Science & Technology
摘要：Ferroelectric nematic liquid crystals are polar fluids characterized by microscopic orientational ordering and macroscopic spontaneous polarizations. Within these fluids, domain walls that separate regions of different polarizations are ubiquitous. We demonstrate that the it walls in films of the polar fluids consist of twin half- integer surface disclinations spaced horizontally, enclosing a subdomain where the polarization exhibits left- or right- handed it twists across the film. The degene...
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作者：Zeng, Yimeng; Xiong, Bingsen; Gao, Hongyao; Liu, Chao; Chen, Changming; Wu, Jianhui; Qin, Shaozheng
作者单位：Beijing University of Chinese Medicine; Beijing Normal University; Beijing Normal University; Beijing Normal University; Beijing Normal University; Chongqing Normal University; Shenzhen University; Chinese Institute for Brain Research, Beijing
摘要：Emotion and cognition involve an intricate crosstalk of neural and endocrine systems that support dynamic reallocation of neural resources and optimal adaptation for upcoming challenges, an active process analogous to allostasis. As a hallmark of human endocrine activity, the cortisol awakening response (CAR) is recognized to play a critical role in proactively modulating emotional and executive functions. Yet, the underlying mechanisms of such proactive effects remain elusive. By leveraging p...
