Synaptic Gα12/13 signaling establishes hippocampal PV inhibitory circuits

• 成果类型: Article
• 署名作者: Garbett, Krassimira; Tosun, Baris; Lopez, Jaybree M.; Smith, Cassandra M.; Honkanen, Kelly; Sando, Richard C.
• 署名单位: Vanderbilt University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8793
• DOI: 10.1073/pnas.2407828121
• 发表日期: 2024-12-24
• 关键词: flamingo; plasticity; axon; RECOGNITION; mechanisms; complexes; molecules; proteins; spines; inputs

摘要

Combinatorial networks of cell adhesion molecules and cell surface receptors drive fundamental aspects of neural circuit establishment and function. However, the intracellular signals orchestrated by these cell surface complexes remain less understood. Here, we report that the G alpha 12/13 pathway lies downstream of several GPCRs with critical synaptic functions. Impairment of the G alpha 12/13 pathway in postnatal hippocampal neurons diminishes inhibitory inputs without altering neuronal morphology or excitatory transmission. G alpha 12/13 signaling in hippocampal CA1 neurons in vivo selectively regulates PV interneuron synaptic connectivity, supporting an inhibitory synapse subtype- specific function of this pathway. Our studies establish G alpha 12/13 as a signaling node that shapes inhibitory hippocampal circuitry.