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作者：Zhang, Albert
作者单位：University of California System; University of California San Francisco
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作者：Gao, Haiyou; Wei, Xiumei; Li, Kang; Cao, Yi; Rao, Wenzhuo; Zhang, Jiansong; Wang, Ding; Yang, Jialong
作者单位：East China Normal University
摘要：Fever confers significant survival benefits on endotherms by optimizing both innate and adaptive immunity. Ectotherms achieve thermoregulation using behavioral strategies, but existing evidence supports its enhancement effect on innate immunity only. Therefore, it remains unknown whether the coordination between fever and adaptive immunity was independently acquired by endotherms or instead represents a gradually evolved function common to vertebrates. In the present study, we reported that Ni...
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作者：Hartmann, Jakob; Klengel, Claudia; Dillmann, Larissa J.; Hisey, Erin E.; Hafner, Kathrin; Shukla, Rammohan; Estruch, Marina Soliva; Bajaj, Thomas; Ebert, Tim; Mabbott, Katharine G.; Rostin, Luise; Philipsen, Alexandra; Carlezon Jr, William A.; Gisabella, Barbara; Mccullumsmith, Robert E.; Vergis, John M.; Klengel, Torsten; Daskalakis, Nikolaos P.; Pantazopoulos, Harry; Gassen, Nils C.; Ressler, Kerry J.
作者单位：Harvard University; Harvard University Medical Affiliates; McLean Hospital; Max Planck Society; University of Wyoming; University of Bonn; University of Mississippi Medical Center; University of Mississippi; University System of Ohio; University of Toledo
摘要：Genes involved in regulating the hypothalamic-pituitary-adrenal (HPA) axis, including the glucocorticoid receptor (GR), are linked to various stress- related psychopathologies including bipolar disorder as well as other mood and trauma- related disorders. The protein product of the cell cycle gene, SKA2, is a GR interaction partner in peripheral cells. However, the precise roles of SKA2 in stress and GR signaling in the brain, specifically in nonreplicating postmitotic neurons, and its involve...
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作者：Hata, Masayuki; Hata, Maki; Dejda, Agnieszka; Pilon, Frederique; Diaz-Marin, Roberto; Fournier, Frederik; Joyal, Jean- Sebastien; Cagnone, Gael; Ochi, Yotaro; Crespo-Garcia, Sergio; Wilson, Ariel M.; Sapieha, Przemyslaw
作者单位：Universite de Montreal; Universite de Montreal; Kyoto University
摘要：Tissue inflammation is often broadly associated with cellular damage, yet sterile inflammation also plays critical roles in beneficial tissue remodeling. In the central nervous system, this is observed through a predominantly innate immune response in retinal vascular diseases such as age- related macular degeneration, diabetic retinopathy, and retinopathy of prematurity. Here, we set out to elucidate the dynamics of the immune response during progression and regression of pathological neovasc...
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作者：Purnomo, Gludhug A.; Kealy, Shimona; O'Connor, Sue; Schapper, Antoinette; Shaw, Ben; Llamas, Bastien; Teixeira, Joao C.; Sudoyo, Herawati; Tobler, Raymond
作者单位：University of Adelaide; University of Adelaide; Australian National University; Australian National University; Vrije Universiteit Amsterdam; Centre National de la Recherche Scientifique (CNRS); Australian National University; Australian National University; John Curtin School of Medical Research; The Kids Research Institute Australia; Universidade de Coimbra
摘要：The tropical archipelago of Wallacea was first settled by anatomically modern humans (AMH) by 50 thousand years ago (kya), with descendent populations thought to have remained genetically isolated prior to the arrival of Austronesian seafarers around 3.5 kya. Modern Wallaceans exhibit a longitudinal countergradient of Papuan- and Asian- related ancestries widely considered as evidence for mixing between local populations and Austronesian seafarers, though converging multidisciplinary evidence ...
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作者：Warnberg, Emil; Kumar, Arvind
作者单位：Karolinska Institutet; Royal Institute of Technology
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作者：Sheriff, Andrew; Zhou, Guangyu; Sagar, Vivek; Morgenthaler, Justin B.; Cyr, Christopher; Hauner, Katherina K.; Omidbeigi, Mahmoud; Rosenow, Joshua M.; Schuele, Stephan U.; Lane, Gregory; Zelano, Christina
作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine
摘要：Nested sleep oscillations, emerging from asynchronous states in coordinated bursts, are critical for memory consolidation. Whether these bursts emerge intrinsically or from an underlying rhythm is unknown. Here, we show a previously undescribed respiratory- driven oscillation in the human hippocampus that couples with cardinal sleep oscillations. Further, breathing promotes nesting of ripples in slow oscillations, together suggesting that respiration acts as an intrinsic rhythm to coordinate s...
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作者：Tavares, Mariana R.; dos Santos, Willian O.; Amaral, Andressa G.; List, Edward O.; Kopchick, John J.; Alves, Guilherme A.; Frazao, Renata; dos Santos, Jessica D. M.; Cruz, Alessandra G.; Camporez, Joao Paulo; Donato Jr, Jose
作者单位：Universidade de Sao Paulo; Institute Biomed Science, University Sao Paulo; University System of Ohio; Ohio University; University System of Ohio; Ohio University; Universidade de Sao Paulo; Institute Biomed Science, University Sao Paulo; Universidade de Sao Paulo
摘要：Growth hormone (GH) has several metabolic effects, including a profound impact on glucose homeostasis. For example, GH oversecretion induces insulin resistance and increases the risk of developing diabetes mellitus. Here, we show that GH receptor (GHR) ablation in vesicular glutamate transporter 2 (VGLUT2)- expressing cells, which comprise a subgroup of glutamatergic neurons, led to a slight decrease in lean body mass without inducing changes in body adiposity. VGLUT2 triangle GHR mice exhibit...
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作者：Yang, Jiao; Dan, Jiameng; Zhao, Nannan; Liu, Linlin; Wang, Huasong; Liu, Qiangqiang; Wang, Lingling; Li, Jie; Wu, Yiwei; Chen, Feilong; Fu, Weilun; Liu, Fei; Lin, Meiqi; Zhang, Weiyu; Chen, Fuquan; Liu, Xinqi; Lu, Xinyi; Chen, Quan; Wu, Xudong; Niu, Yuyu; Yang, Na; Zhu, Yushan; Long, Jiafu; Liu, Lin
作者单位：Nankai University; Nankai University; Kunming University of Science & Technology; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Nankai University; Nankai University; Tianjin Medical University; Nankai University
摘要：Zygotic genome activation occurs in two-cell (2C) embryos, and a 2C-like state is also activated in sporadic (similar to 1%) naive embryonic stem cells in mice. Elevated chromatin accessibility is critical for the 2C-like state to occur, yet the underlying molecular mechanisms remain elusive. Zscan4 exhibits burst expression in 2C embryos and 2C-like cells. Here, we show that Zscan4 mediates chromatin remodeling to promote the chromatin accessibility for achieving the 2C-like state. Through co...
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作者：Kazerani, Maryam; Cernilogar, Filippo; Pasquarella, Alessandra; Hinterberger, Maria; Nuber, Alexander; Klein, Ludger; Schotta, Gunnar
作者单位：Bavarian Nordic; University of Munich; University of Eastern Piedmont Amedeo Avogadro; University of Munich
摘要：The H3K9me3- specific histone methyltransferase SETDB1 is critical for proper regulation of developmental processes, but the underlying mechanisms are only partially understood. Here, we show that deletion of Setdb1 in mouse fetal liver hematopoietic stem and progenitor cells (HSPCs) results in compromised stem cell function, enhanced myeloerythroid differentiation, and impaired lymphoid development. Notably, Setdb1- deficient HSPCs exhibit reduced quiescence and increased proliferation, accom...
