-
作者：Li, Yixuan; Ong, Hui Ting; Cui, Hongyue; Gao, Xu; Lee, Jia Wen Nicole; Guo, Yuqi; Li, Rong; Pennacchio, Fabrizio A.; Maiuri, Paolo; Efremov, Artem K.; Holle, Andrew W.
作者单位：National University of Singapore; National University of Singapore; Shenzhen Bay Laboratory; National University of Singapore; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Naples Federico II
摘要：Diverse tissues in vivo present varying degrees of confinement, constriction, and compression to migrating cells in both homeostasis and disease. The nucleus in particular is subjected to external forces by the physical environment during confined migration. While many systems have been developed to induce nuclear deformation and analyze resultant functional changes, much remains unclear about dynamic volume regulation in confinement due to limitations in time resolution and difficulty imaging...
-
作者：Mccullagh, Karl J. A.; Calabria, Elisa; Pallafacchina, Giorgia; Ciciliot, Stefano; Serrano, Antonio L.; Argentini, Carla; Kalhovde, John M.; Lomo, Terje; Schiaffino, Stefano
-
作者：Nava, Hernaldo Mendoza; Holderied, Marc W.; Pirrera, Alberto; Groh, Rainer M. J.
-
作者：Fedeli, Sirio Belga; Leibler, Stanislas
作者单位：Institute for Advanced Study - USA; Rockefeller University
摘要：In view of changing climatic conditions and disappearing natural resources such as fertile soil and water, exploring alternatives to today's industrial monocrop farming becomes essential. One promising farming practice is intercropping (IC), in which two or more crop species are grown together. Many experiments have shown that, under certain circumstances, IC can decrease soil erosion and fertilizer use, improve soil health and land management, while preserving crop production levels. However,...
-
作者：Head, Louise C.; Negro, Giuseppe; Carenza, Livio N.; Johnson, Nathan; Keogh, Ryan R.; Gonnella, Giuseppe; Morozov, Alexander; Orlandini, Enzo; Shendruk, Tyler N.; Tiribocchi, Adriano; Marenduzzo, Davide
作者单位：University of Edinburgh; Koc University; Universita degli Studi di Bari Aldo Moro; Istituto Nazionale di Fisica Nucleare (INFN); University of Padua; Istituto Nazionale di Fisica Nucleare (INFN); Consiglio Nazionale delle Ricerche (CNR)
摘要：Quasiparticles are low-energy excitations with important roles in condensed matter physics. An intriguing example is provided by Majorana quasiparticles, which are equivalent to their antiparticles. Despite being implicated in neutrino oscillations and topological superconductivity, their experimental realizations remain very rare. Here, we propose a purely classical realization of Majorana fermions in terms of three-dimensional disclination lines in active nematics. The underlying reason is t...
-
作者：Hundley, Frances, V; Gonzalez-Lozano, Miguel A.; Gottschalk, Lena M.; Cook, Aslan N. K.; Zhang, Jiuchun; Paulo, Joao A.; Harper, J. Wade
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
摘要：Plasma membrane protein degradation and recycling are regulated by the endolysosomal system, wherein endocytic vesicles bud from the plasma membrane into the cytoplasm and mature into endosomes and then degradative lysosomes. As such, the endolysosomal system plays a critical role in determining the abundance of proteins on the cell surface and influencing cellular identity and function. Highly polarized cells, like neurons, rely on the endolysosomal system for axonal and dendritic specializat...
-
作者：da Silva, Jack
作者单位：University of Adelaide
-
作者：Lauwers, Yoline; De Groof, Timo W. M.; Vincke, Cecile; Van Craenenbroeck, Jolien; Jumapili, Neema Ahishakiye; Barthelmess, Romina Mora; Courtoy, Guillaume; Waelput, Wim; De Pauw, Tessa; Raes, Geert; Devoogdt, Nick; Van Ginderachter, Jo A.
作者单位：Vrije Universiteit Brussel; Flanders Institute for Biotechnology (VIB); Vrije Universiteit Brussel; University Hospital Brussels; Vrije Universiteit Brussel; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc; Vrije Universiteit Brussel
摘要：Immunotherapies have emerged as an effective treatment option for immune- related diseases, such as cancer and inflammatory diseases. However, variations in patient responsiveness limit the broad applicability and success of these immunotherapies. Noninvasive whole- body imaging of the immune status of individual patients during immunotherapy could enable the prediction and monitoring of the patient's response, resulting in more personalized treatments. In this study, we developed a nanobody-b...
-
作者：Li, Gen; Liu, Ting; Xie, Wangliang; Liu, Zhenzhen; Li, Huixin; Whalen, Joann K.; Jousset, Alexandre; Wei, Zhong
作者单位：Nanjing Agricultural University; McGill University; Mohammed VI Polytechnic University
摘要：Predator-prey interactions are a major driver of microbiome dynamics, but remain difficult to predict. While several prey traits potentially impact resistance to predation, their effects in a multispecies context remain unclear. Here, we leverage synthetic bacterial communities of varying complexity to identify traits driving palatability for nematodes, a main consumer of bacteria in soil. We assessed trophic interactions between four nematode species and 122 bacterial isolates, across a gradi...
-
作者：Ruperti, Fabian; Dzieciatkowska, Monika; Pankey, M. Sabrina; Asensio, Cedric S.; Anselmetti, Dario; Fernandez-Busquets, Xavier; Nichols, Scott A.
作者单位：European Molecular Biology Laboratory (EMBL); University of Colorado System; University of Colorado Anschutz Medical Campus; University System Of New Hampshire; University of New Hampshire; University of Denver; University of Bielefeld; ISGlobal; University of Barcelona; Hospital Clinic de Barcelona; University of Barcelona; Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya
摘要：The discovery that sponges (Porifera) can fully regenerate from aggregates of dissociated cells launched them as one of the earliest experimental models to study the evolution of cell adhesion and allorecognition in animals. This process depends on an extracellular glycoprotein complex called the Aggregation Factor (AF), which is composed of proteins thought to be unique to sponges. We used quantitative proteomics to identify additional AF components and interacting proteins in the classical m...
