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作者：Patel, Aum R.; Garg, Amit; Rosberger, Haylen T.; Kowdle, Shreyas; Reis, Rebecca A.; Frere, Justin J.; Januska, Megan N.; Dawodu, Gbalekan; Valencia, Estefania; Yang, Min-Chi; Stevens, Christian S.; Rao, Vishal N.; Haas, Griffin D.; Chen, Ya-Wen; Lee, Benhur; Lim, Jean K.
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：Formerly a common childhood pathogen, mumps virus (MuV) remains active worldwide, despite relatively high vaccine coverage. MuV is thought to infect the upper respiratory tract before disseminating to other organs; however, the early cellular targets of MuV in vivo are unknown. To address this, we generated a green fluorescent protein (GFP)- tagged vaccine strain (JL5) of MuV to infect leukocytic cell lines and found that replication was greatest in monocytes. Infection of peripheral blood mon...
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作者：Raffi, Gabriele Casagrande; Chen, Jian; Feng, Xuezhao; Chen, Zhen; Lieftink, Cor; Deng, Shuang; Mo, Jinzhe; Zeng, Chuting; Steur, Marit; Wang, Jing; Bleijerveld, Onno B.; Hoekman, Liesbeth; van der Wel, Nicole; Wang, Feng; Beijersbergen, Roderick; Zheng, Jian; Bernards, Rene; Wang, Liqin
作者单位：Netherlands Cancer Institute; Sun Yat Sen University; State Key Lab Oncology South China; Netherlands Cancer Institute; Netherlands Cancer Institute; University of Amsterdam
摘要：Drugs that eliminate senescent cells, senolytics, can be powerful when combined with here SLC25A23 as a vulnerability of senescent cancer cells. Suppressing SLC25A23 disrupts cellular calcium homeostasis, impairs oxidative phosphorylation, and interferes with redox signaling, leading to death of senescent cells. These effects can be replicated by salinomycin, a cation ionophore antibiotic. Salinomycin prompts a pyroptosis- apoptosis- necroptosis (PAN)optosis- like cell death in senescent cells...
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作者：Shearer, Charles K.; Sharp, Zachary D.; Stopar, Julie
作者单位：University of New Mexico; University of New Mexico; Universities Space Research Association (USRA)
摘要：Numerous missions to the Moon have identified and documented volatile deposits associated with permanently shadowed regions. A series of science goals for the Artemis Program is to explore these volatile deposits and return samples to Earth. Volatiles in these reservoirs may consist of a variety of species whose stable isotope characteristics could elucidate both their sources and the processes instrumental in their formation. For example, the delta D of potential contributors to the deposits ...
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作者：Thiemens, Mark H.; Pack, Andreas; Sharp, Zachary
作者单位：University of California System; University of California San Diego; University of Gottingen; University of New Mexico
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作者：Zhou, Yangyang; Liu, Pengtao; Tang, Yaqi; Liu, Jie; Tang, Yaru; Zhuang, Yumeng; Li, Xiaoting; Xu, Kaiqi; Zhou, Zhi; Li, Jigang; He, Guangming; Deng, Xing Wang; Yang, Li
作者单位：China Agricultural University; Peking University; Peking University; China Agricultural University; Peking University
摘要：Light is a major determinant of plant growth and survival. NONEXPRESSER OF PATHOGENESIS- RELATED GENES 1 (NPR1) acts as a receptor for salicylic acid (SA) and serves as the key regulator of SA- mediated immune responses. However, the mechanisms by which plants integrate light and SA signals in response to environmental changes, as well as the role of NPR1 in regulating plant photomorphogenesis, remain poorly understood. This study shows that SA promotes plant photomorphogenesis by regulating P...
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作者：Fischer, Meike; Peters, Stefan T. M.; Herwartz, Daniel; Hartogh, Paul; Di Rocco, Tommaso; Pack, Andreas
作者单位：University of Gottingen; Max Planck Society; Thermo Fisher Scientific; University of Cologne; Ruhr University Bochum
摘要：The Moon formed 4.5 Ga ago through a collision between proto-Earth and a planetesimal known as Theia. The compositional similarity of Earth and Moon puts tight limits on the isotopic contrast between Theia and proto- Earth, or it requires intense homogenization of Theia and proto-Earth material during and in the aftermath of the Moon- forming impact, or a combination of both. We conducted precise measurements of oxygen isotope ratios of lunar and terrestrial rocks. The absence of an isotopic d...
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作者：Hou, Jianing; Guo, Pei; Wang, Junyan; Han, Da; Tan, Weihong
作者单位：Shanghai Jiao Tong University; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS
摘要：Artificially functional RNAs, such as fluorogenic RNA aptamer (FRApt)-based biosensing tag, represent significant advancements in various biological applications but are limited by the lack of insight into dynamic structure ensembles and universal design concepts. Through the development of an artificial RNA structure ensemble, we rationally established an RNA reconstitution model, SSPepper- Apt, to generate a universal fluorogenic RNA biosensing tag. By utilizing various target- recognizing R...
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作者：Kravtsova-Ivantsiv, Yelena; Goldhirsh, Gilad; Ciechanover, Aaron
作者单位：Technion Israel Institute of Technology; Rappaport Faculty of Medicine; Technion Israel Institute of Technology
摘要：Cytokines constitute a family of proteins that modulate the immune system and are secreted by many cells. CXCL12, along with its receptor CXCR4, are essential players in numerous processes. Dysregulation of their function underlie the mechanism(s) of several pathologies, including malignancies. Here, we demonstrate an unexpected effect of the cytokine and its receptor: In both cells and animal models, CXCL12 restricts tumorigenicity of the human glioblastoma cells U87- MG and U- 118, and of a ...
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作者：Li, Lei-Lei; Xiao, Yujie; Wang, Baohui; Zhuang, Yunqi; Chen, Yumeng; Lu, Jing; Lou, Yonggen; Li, Ran
作者单位：Zhejiang University; Zhejiang Chinese Medical University
摘要：CRISPR- Cas9 genome editing systems have revolutionized plant gene functional studies by enabling the targeted introduction of insertion- deletions (INDELs) via the nonhomologous end- joining (NHEJ) pathway. Frameshift- inducing INDELs can introduce a premature termination codon and, in other instances, can lead to the appearance of new proteins. Here, we found that mutations in the rice jasmonate (JA) signaling gene OsJAZ10 by CRISPR- Cas9- based genome editing did not affect canonical JA sig...
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作者：Allgower, Friederike; Poverlein, Maximilian C.; Rutherford, A. William; Kaila, Ville R. I.
作者单位：Stockholm University; Imperial College London
摘要：Photosystem II (PSII) catalyzes light- driven water oxidation that releases dioxygen into our atmosphere and provides the electrons needed for the synthesis of biomass. The catalysis occurs in the oxygen- evolving oxo- manganese- calcium (Mn4O5Ca) cluster that drives the oxidation and deprotonation of substrate water molecules leading to the O2 formation. However, despite recent advances, the mechanism of these reactions remains unclear and much debated. Here, we show that the light- driven Ty...
