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作者：Rockey, Nicole C.; Le Sage, Valerie; Shephard, Meredith; Vargas-Maldonado, Nahara; Vu, Michelle N.; Brown, Cambria A.; Patel, Krishna; French, Andrea J.; Merrbach, Grace A.; Walter, Sydney; Ferreri, Lucas M.; Holmes, Katie E.; VanInsberghe, David; Clack, Herek L.; Prussin, Aaron J.; Lowen, Anice C.; Marr, Linsey C.; Lakdawala, Seema S.
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作者：Lopez-Garcia, Isabel; Oh, Sunhee; Chaney, Christopher; Tsunezumi, Jun; Drummond, Iain; Oxburgh, Leif; Carroll, Thomas J.; Marciano, Denise K.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Kanagawa Prefectural Cancer Center; Mount Desert Island Biological Laboratory
摘要：The formation of functional epithelial tubules is critical for the development and maintenance of many organ systems. While the mechanisms of tubule formation by epithelial cells are well studied, the process of tubule anastomosis-where tubules connect to form a continuous network-remains poorly understood. In this study, we utilized single- cell RNA sequencing to analyze embryonic mouse kidney tubules undergoing anastomosis. Our analysis identified hepatocyte growth factor (HGF) as a key pote...
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作者：Nocchi, Gabriele; Whiting, James R.; Yeaman, Samuel
作者单位：University of Calgary
摘要：Global adaptation occurs when all populations of a species undergo selection toward a common optimum. This can occur by a hard selective sweep with the emergence of a new globally advantageous allele that spreads throughout a species' natural range until reaching fixation. This evolutionary process leaves a temporary trace in the region affected, which is detectable using population genomic methods. While selective sweeps have been identified in many species, there have been few comparative an...
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作者：Szathmary, Eoers
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作者：Mousa, Mohamed; Nouh, Mostafa
作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY
摘要：Decades after being replaced with digital platforms, analogue computing has spatial transformations on an incident wavefront, commensurate with a desired mathematical operation, have gained traction owing to their ability to directly encode the input in its unprocessed form, bypassing analogue-to-digital conversion. While promising, these systems are inherently limited to single-task configurations. Their inability to concurrently perform multiple tasks, or compute in parallel, represents a ma...
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作者：Sun, Xin; Buchanan, Pearse J.; Zhang, Irene H.; San Roman, Magdalena; Babbin, Andrew R.; Zakem, Emily J.
作者单位：Carnegie Institution for Science; Commonwealth Scientific & Industrial Research Organisation (CSIRO); Massachusetts Institute of Technology (MIT); University of Southern California; University of Salamanca; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-USAL - Instituto de Biologia Funcional y Genomica (IBFG)
摘要：Microorganisms in marine oxygen minimum zones (OMZs) drive globally impactful biogeochemical processes. One such process is multistep denitrification (NO3--NO2 -- NO- N 2 O- N 2 ), which dominates OMZ bioavailable nitrogen (N) loss and nitrous oxide (N2O) production. Denitrification- derived N loss is typically measured and modeled as a single step, but observations reveal that most denitrifiers in OMZs contain subsets (modules) of the complete pathway. Here, we identify the ecological mechani...
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作者：Nadel, Lynn; Simon, Katharine C.
作者单位：University of Arizona; University of Arizona; University of California System; University of California Irvine
摘要：The sharing of personal memories is a unique aspect of the human experience. Humans communicate to provide information, to influence, or even to amuse. How do we distinguish between credible and noncredible narratives? Forensic science has identified race, age, and detail quantity as influential. We do not know how the nature of narrated details impacts believability. We report two studies investigating how detail composition influences credibility ratings using definitions of details suggeste...
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作者：Platt, Jeffrey L.; Zhao, Chong; Chicca, Jeffrey; Pianko, Matthew J.; Han, Joshua; The, Stephanie; Rao, Arvind; Keller, Evan T.; Barbosa, Mayara Garcia de Mattos; Naing, Lwar; Pasieka-Axenov, Tracy; Axenov, Lev; Schaefer, Simon; Farkash, Evan; Cascalho, Marilia
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Erlangen Nuremberg; University of Michigan System; University of Michigan
摘要：Immune surveillance depends in part on the recognition of peptide variants by T cell antigen receptors. Given that both normal B cells and malignant B cells accumulate mutations we chose a murine model of multiple myeloma to test conditions to induce cell- mediated immunity targeting malignant plasma cell (PC) clones but sparing of normal PCs. Revealing a previously unknown function for intracellular C3d, we found that C3d engaged T cell responses against malignant PC in the bone marrow of mic...
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作者：Borjon, Jeremy I.; Sahoo, Manash K.; Rhodes, Katherine D.; Lipschutz, Rebecca; Bick, Johanna R.
作者单位：University of Houston System; University of Houston; University of Houston System; University of Houston; University of Houston System; University of Houston; Emory University
摘要：For human infants, producing recognizable speech is more than a cognitive process. It is a motor skill that requires infants to learn to coordinate multiple muscles of varying functions across their body. This coordination is directly linked to ongoing fluctuations in heart rate; a physiological process that can scaffold behavior. We investigated whether ongoing fluctuations in heart rate coincide with vocal production and word formation in 24-mo-old infants. Infants were most likely to produc...
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作者：Brodsky, Barbara; Persikov, Anton, V
作者单位：Tufts University; Simons Foundation; Flatiron Institute
