-
作者：Middelkoop, Teije C.; Neipel, Jonas; Cornell, Caitlin E.; Naumann, Ronald; Pimpale, Lokesh G.; Juelicher, Frank; Grill, Stephan W.
作者单位：Max Planck Society; Czech Academy of Sciences; Institute of Molecular Genetics of the Czech Academy of Sciences; Max Planck Society; University of California System; University of California Berkeley; Technische Universitat Dresden
摘要：This discovery builds on earlier work from Sachs concerning orientations of subsequent cell divisions (3, 4) and is since known as Hertwig's long axis rule (5-12). Since the mitotic spindle is bisected during cell division for proper chromosome segregation, the axis along which the mitotic spindle is oriented determines the axis of cell division (13). Hence, the orientation of the mitotic spindle determines the axis along which a cell is divided. But how then does the mitotic spindle align wit...
-
作者：Wang, Bingxiao; Zhou, Zhaoyang; Zhou, Jian-Min; Li, Jiejie
作者单位：Beijing Normal University; China Agricultural University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Yazhouwan National Laboratory; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Beijing Normal University
摘要：Plants rely on immune receptor complexes at the cell surface to perceive microbial molecules and transduce these signals into the cell to regulate immunity. Various immune receptors and associated proteins are often dynamically distributed in specific nanodomains on the plasma membrane (PM). However, the exact molecular mechanism and functional relevance of this nanodomain targeting in plant immunity regulation remain largely unknown. By utilizing high spatiotemporal resolution imaging and sin...
-
作者：Yim, Yeong Shin; Kwon, Younghee; Nam, Jungyong; Yoon, Hong In; Lee, Kangduk; Kim, Dong Goo; Kim, Eunjoon; Kim, Chul Hoon; Ko, Jaewon
-
作者：Yu, Jiayun; Li, Hanwen; Wu, Yongyao; Luo, Min; Chen, Siyuan; Shen, Guobo; Wei, Xiawei; Shao, Bin
作者单位：Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University
摘要：The NLRP3 inflammasome, a pivotal component of innate immunity, has been implicated in various inflammatory disorders. The ubiquitin- editing enzyme A20 is well known to regulate inflammation and maintain homeostasis. However, the precise molecular mechanisms by which A20 modulates the NLRP3 inflammasome remain poorly understood. Here, our study revealed that macrophages deficient in A20 exhibit increased protein abundance and elevated mRNA level of NIMA- related kinase 7 (NEK7). Importantly, ...
-
作者：Rieser, Jennifer M.; Chong, Baxi; Gong, Chaohui; Astley, Henry C.; Schiebel, Perrin E.; Diaz, Kelimar; Pierce, Christopher J.; Lu, Hang; Hatton, Ross L.; Choset, Howie; Goldman, Daniel I.
作者单位：University System of Georgia; Georgia Institute of Technology; Emory University; University System of Ohio; University of Akron; Montana State University System; Montana State University Bozeman; University System of Georgia; Georgia Institute of Technology; Oregon State University; Carnegie Mellon University
摘要：Self-propelling organisms locomote via generation of patterns of self-deformation. Despite the diversity of body plans, internal actuation schemes and environments in limbless vertebrates and invertebrates, such organisms often use similar traveling waves of axial body bending for movement. Delineating how self-deformation parameters lead to locomotor performance (e.g. speed, energy, turning capabilities) remains challenging. We show that a geometric framework, replacing laborious calculation ...
-
作者：He, Xin; Ni, Youxuan; Ma, Wenjiao; Zhang, Qiu; Hao, Zhenkun; Hou, Yunpeng; Li, Haixia; Yan, Zhenhua; Zhang, Kai; Chen, Jun
作者单位：Nankai University; Hunan University
摘要：Rechargeable sodium - oxygen (Na-O 2 ) battery is deemed as a promising high - energy storage device due to the abundant sodium resources and high theoretical energy density (1,108 Wh kg -1 ). A series of quasisolid electrolytes are constantly being designed to restrain the dendrites growth, the volatile and leaking risks of liquid electrolytes due to the open system of Na-O 2 batteries. However, the ticklish problem about low operating current density for quasisolid electrolytes still hasn't ...
-
作者：Goto, Sawako; Tsutsumi, Akihisa; Lee, Yongchan; Hosojima, Michihiro; Kabasawa, Hideyuki; Komochi, Koichi; Nagatoishi, Satoru; Takemoto, Kazuya; Tsumoto, Kouhei; Nishizawa, Tomohiro; Kikkawa, Masahide; Saito, Akihiko
作者单位：Niigata University; University of Tokyo; Yokohama City University; Niigata University; University of Tokyo; University of Tokyo; Daiichi Sankyo Company Limited
摘要：Megalin (low - density lipoprotein receptor - related protein 2) is a giant glycoprotein of about 600 kDa, mediating the endocytosis of more than 60 ligands, including those of proteins, peptides, and drug compounds [S. Goto, M. Hosojima, H. Kabasawa, A. Saito, Int. J. Biochem. Cell Biol. 157 , 106393 (2023)]. It is expressed predominantly in renal proximal tubule epithelial cells, as well as in the brain, lungs, eyes, inner ear, thyroid gland, and placenta. Megalin is also known to mediate th...
-
作者：Shioda, Tatsuya; Nakamura, Shuhei
作者单位：University of Osaka; Nara Medical University
-
作者：Tang, Kai; Zhu, Xiaohong; Xie, Shaojun; Lang, Zhaobo; Zhu, Jian-Kang
作者单位：Purdue University System; Purdue University; Henan University; Henan University; Purdue University System; Purdue University; Southern University of Science & Technology; Southern University of Science & Technology
摘要：Spontaneous gain or loss of DNA methylation occurs in plant and animal genomes, and DNA methylation changes can lead to meiotically stable epialleles that generate heritable phenotypic diversity. However, it is unclear whether transgenerational epigenetic stability may be regulated by any cellular factors. Here, we examined spontaneously occurring variations in DNA methylation in wild - type and ros1 mutant Arabidopsis plants that were propagated for ten generations from single - seed descent....
-
作者：Hammond, Ross A.; Barkin, Shari
作者单位：Washington University (WUSTL); Brookings Institution; The Santa Fe Institute; Virginia Commonwealth University; Virginia Commonwealth University
