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作者：Janet, Remi; Smallwood, Jonathan; Hutcherson, Cendri A.; Plassmann, Hilke; McKeown, Bronte; Tusche, Anita
作者单位：Queens University - Canada; University of Toronto; University of Toronto; INSEAD Business School; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; California Institute of Technology
摘要：Making healthy dietary choices is essential for keeping weight within a normal range. Yet many people struggle with dietary self - control despite good intentions. What distinguishes neural processing in those who succeed or fail to implement healthy eating goals? Does this vary by weight status? To examine these questions, we utilized an analytical framework of gradients that characterize systematic spatial patterns of large - scale neural activity, which have the advantage of considering the...
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作者：Jo, Kyoung-nam
作者单位：Kangwon National University
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作者：Iyengar, Srikanth B.; Khare, Chandrashekhar B.; Manning, Jeffrey; Urban, Eric
作者单位：Utah System of Higher Education; University of Utah; University of California System; University of California Los Angeles; Imperial College London; Columbia University
摘要：This article builds on recent work of the first three authors where a notion of congruence modules in higher codimension is introduced. The main results are a criterion for detecting regularity of local rings in terms of congruence modules, and a more refined version of a result tracking the change of congruence modules under deformation. Number theoretic applications include the construction of canonical lines in certain Galois cohomology groups arising from adjoint motives of Hilbert modular...
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作者：Jiang, Min; Huang, Ying; Guo, Chang; Su, Haowen; Wang, Yuanhong; Peng, Xinhua; Budker, Dmitry
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; CAS Center for Excellence in Quantum Information & Quantum Physics; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; Johannes Gutenberg University of Mainz; University of California System; University of California Berkeley
摘要：Quantum amplification enables the enhancement of weak signals and is of great importance for precision measurements, such as biomedical science and tests of fundamental symmetries. Here, we observe a previously unexplored magnetic amplification using dark noble -gas nuclear spins in the absence of pump light. Such dark spins exhibit remarkable coherence lasting up to 6 min and the resilience against the perturbations caused by overlapping alkali -metal gas. We demonstrate that the observed phe...
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作者：Hiyoshi, Hideyuki; Sakuma, Kensuke; Asano, Shinya; Napier, Stephanie C.; Konagaya, Shuhei; Mochida, Taisuke; Ueno, Hikaru; Watanabe, Takeshi; Kassai, Yoshiaki; Matsumoto, Hirokazu; Ito, Ryo; Toyoda, Taro
作者单位：Takeda Pharmaceutical Company Ltd; Kyoto University; Takeda Pharmaceutical Company Ltd; Kyoto University
摘要：Differentiation of pancreatic endocrine cells from human pluripotent stem cells (PSCs) has been thoroughly investigated for application in cell therapy against diabetes. In the context of induced pancreatic endocrine cell implantation, previous studies have reported graft enlargement resulting from off - target pancreatic lineage cells. However, there is currently no documented evidence of proliferative off- target cells beyond the pancreatic lineage in existing studies. Here, we show that the...
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作者：Miangolarra, Ander Movilla; Saxton, Daniel S.; Yan, Zhi; Rine, Jasper; Howard, Martin
作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; University of California System; University of California Berkeley
摘要：Compact chromatin is closely linked with gene silencing in part by sterically masking access to promoters, inhibiting transcription factor binding and preventing polymerase from efficiently transcribing a gene. However, a broader hypothesis suggests that chromatin compaction can be both a cause and a consequence of the locus histone modification state, with a tight bidirectional interaction underpinning bistable transcriptional states. To rigorously test this hypothesis, we developed a mathema...
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作者：Leder, Dirk; Lehmann, Jens; Milks, Annemieke; Koddenberg, Tim; Sietz, Michael; Vogel, Matthias; Boehner, Utz; Ae, Thomas Terberger
作者单位：University of Reading; University of Gottingen; University of Gottingen
摘要：Ethnographic records show that wooden tools played a pivotal role in the daily lives of hunter- gatherers including food procurement tools used in hunting (e.g., spears, throwing sticks) and gathering (e.g. digging sticks, bark peelers), as well as, domestic tools (e.g., handles, vessels). However, wood rarely survives in the archeological record, especially in Pleistocene contexts and knowledge of prehistoric hunter- gatherer lifeways is strongly biased by the survivorship of more resilient m...
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作者：Swarnkar, Gaurav; Semenkovich, Nicholas P.; Arra, Manoj; Mims, Dorothy K.; Naqvi, Syeda Kanwal; Peterson, Timothy; Mbalaviele, Gabriel; Wu, Chia- Lung; Abu-Amer, Yousef
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作者：Zenga, Jialiu; Loia, Gavin Wen Zhao; Saipuljumria, Eka Norfaishanty; Duranc, Marco Antonio Romero; Silva-Garciac, Octavio; Aguilard, Jose Manuel Perez-; Baizabal-Aguirrec, Victor M.; Loa, Chih Hung
作者单位：Nanyang Technological University; Universidad Michoacana de San Nicolas de Hidalgo
摘要：Tumor necrosis factor (TNF) receptor 1 (TNFR1) plays a pivotal role in mediating TNF induced downstream signaling and regulating inflammatory response. Recent studies have suggested that TNFR1 activation involves conformational rearrangements of preligand assembled receptor dimers and targeting receptor conformational dynamics is a viable strategy to modulate TNFR1 signaling. Here, we used a combination of biophysical, biochemical, and cellular assays, as well as molecular dynamics simulation ...
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作者：Noerr, Patrick S.; Alvarado, Jose E. Zamora; Golnaraghi, Farnaz; McCloskey, Kara E.; Gopinathan, Ajay; Dasbiswas, Kinjal
