A cytokinetic ring- driven cell rotation achieves Hertwig's rule in early development

• 成果类型: Article
• 署名作者: Middelkoop, Teije C.; Neipel, Jonas; Cornell, Caitlin E.; Naumann, Ronald; Pimpale, Lokesh G.; Juelicher, Frank; Grill, Stephan W.
• 署名单位: Max Planck Society; Czech Academy of Sciences; Institute of Molecular Genetics of the Czech Academy of Sciences; Max Planck Society; University of California System; University of California Berkeley; Technische Universitat Dresden
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-10249
• DOI: 10.1073/pnas.2318838121
• 发表日期: 2024-06-18
• 页码: 10-10
• 关键词: mitotic spindle; microtubule asters; force generators; tissue tension; pulling force; 1st cleavage; division; shape; orientation; mechanisms

摘要

This discovery builds on earlier work from Sachs concerning orientations of subsequent cell divisions (3, 4) and is since known as Hertwig's long axis rule (5-12). Since the mitotic spindle is bisected during cell division for proper chromosome segregation, the axis along which the mitotic spindle is oriented determines the axis of cell division (13). Hence, the orientation of the mitotic spindle determines the axis along which a cell is divided. But how then does the mitotic spindle align with the long axis of a cell, thereby facilitating If misaligned, moving the spindle to orient it with the long axis of the cell requires force generation. What types of forces can act upon microtubules and microtubule asters? We distinguish force generation inside the cell, within the cytoplasm, from force generation at the cell cortex. First, within the cytoplasm, dynein motors that are attached to cytoSecond, microtubules that grow toward the periphery can continue to do so as they