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作者：Parker, Diana; Tosiani, Anna; Yazid, Muhammad; Sari, Inggit L.; Kartika, Tatik; Kustiyoc; Firmansyah, Rizky; Said, Zuraidah; Wijaya, Arief; Potapov, Peter; Tyukavina, Alexandra; Stehman, Stephen V.; Zalles, Viviana; Pickens, Amy; Pickering, Jeffrey; Turubanova, Svetlana; Hansen, Matthew C.
作者单位：University System of Maryland; University of Maryland College Park; Ministry of Environment & Forestry; National Research & Innovation Agency of Indonesia (BRIN); State University of New York (SUNY) System; State University of New York (SUNY) College of Environmental Science & Forestry
摘要：Indonesia has experienced rapid primary forest loss, second only to Brazil in modern history. We examined the fates of Indonesian deforested areas, immediately after clearing and over time, to quantify deforestation drivers in Indonesia. Using time- series satellite data, we tracked degradation and clearing events in intact and degraded natural forests from 1991 to 2020, as well as land use trajectories after forest loss. While an estimated 7.8 Mha (SE = 0.4) of forest cleared during this peri...
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作者：Tang, Feng; Wang, Yinan; Zhao, Ting; Yuan, Jun; Wang, Yinsheng
作者单位：University of California System; University of California Riverside; University of California System; University of California Riverside
摘要：Cycling cells replicate their DNA during the S phase through a defined temporal program known as replication timing. Mutation frequencies, epigenetic chromatin states, and transcriptional activities are different for genomic regions that are replicated early and late in the S phase. Here, we found from ChIP- Seq analysis that DNA polymerase (Pol) kappa is enriched in early- replicating genomic regions in HEK293T cells. In addition, by feeding cells with N 2- heptynyl- 2 '- deoxyguanosine follo...
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作者：Batista, Bruno C.; Tekle, Semhare D.; Yan, Jie; Dangi, Beni B.; Steinbock, Oliver
作者单位：State University System of Florida; Florida State University; University System of Maryland; Bowie State University; State University System of Florida; Florida A&M University; Florida State University
摘要：Under nonequilibrium conditions, inorganic systems can produce a wealth of life - like shapes and patterns which, compared to well- formed crystalline materials, remain widely unexplored. A seemingly simple example is the formation of salt deposits during the evaporation of sessile droplets. These evaporites show great variations in their specific patterns including single rings, creep, small crystals, fractals, and featureless disks. We have explored the patterns of 42 different salts at othe...
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作者：Feng, Qiumin; Zhao, Danhui; Lin, Zejin; Li, Mengzhao; Xiang, Andy Peng; Ye, Congting; Yao, Chengguo
作者单位：Sun Yat Sen University; Xiamen University; Sun Yat Sen University; Sun Yat Sen University
摘要：The essential role of U4 snRNP in pre - messenger RNA (mRNA) splicing has been well established. In this study, we utilized an antisense morpholino oligonucleotide (AMO) specifically targeting U4 snRNA to achieve functional knockdown of U4 snRNP in HeLa cells. Our results showed that this knockdown resulted in global intronic premature cleavage and polyadenylation (PCPA) events, comparable to the effects observed with U1 AMO treatment, as demonstrated by mRNA 3 '- seq analysis. Furthermore, ou...
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作者：Li, Tianyi; Xu, Hui; Teng, Shouzhen; Suo, Mingrui; Bahitwa, Revocatus; Xu, Mingchi; Qian, Yiheng; Ramstein, Guillaume P.; Song, Baoxing; Buckler, Edward S.; Wang, Hai
作者单位：China Agricultural University; Aarhus University; Peking University; Northwest A&F University - China; Cornell University; United States Department of Agriculture (USDA); China Agricultural University
摘要：Rational design of plant cis - regulatory DNA sequences without expert intervention or prior domain knowledge is still a daunting task. Here, we developed PhytoExpr, a deep learning framework capable of predicting both mRNA abundance and plant species using the proximal regulatory sequence as the sole input. PhytoExpr was trained over 17 species representative of major clades of the plant kingdom to enhance its generalizability. Via input perturbation, quantitative functional annotation of the...
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作者：Mun, Jaewan; Navarro, Nicole; Jeong, Sanghwa; Ouassil, Nicholas; Leem, Esther; Beyene, Abraham G.; Landry, Markita P.; Murphy, Catherine
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Pusan National University; Howard Hughes Medical Institute; Chan Zuckerberg Initiative (CZI)
摘要：Oxytocin plays a critical role in regulating social behaviors, yet our understanding of its function in both neurological health and disease remains incomplete. Real - time oxytocin imaging probes with spatiotemporal resolution relevant to its endogenous signaling are required to fully elucidate oxytocin's role in the brain. Herein, we describe a nearinfrared oxytocin nanosensor (nIROXT), a synthetic probe capable of imaging oxytocin in the brain without interference from its structural analog...
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作者：Brady, Laura M.; Wang, Cong; Griffiths, Camilla; Yang, Jenny; Markus, Hazel R.; Fryberg, Stephanie A.
作者单位：University of Michigan System; University of Michigan; Northwestern University; Stanford University; American Institutes for Research
摘要：Despite an abundance of support for culturally inclusive learning environments, there is little consensus regarding how to change educational contexts to effectively and sustainably foster cultural inclusion. To address this gap, we report findings from a research-practice partnership that leveraged the Culture Cycle Framework (CCF) to expand educators' praxis to include both independent and interdependent models of self. Most U.S. schools validate independent cultural models (i.e., those that...
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作者：Croke, Kevin; Hamory, Joan; Hsu, Eric; Kremer, Michael; Maertens, Ricardo; Miguel, Edward; Wiecek, Witold
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; University of Oklahoma System; University of Oklahoma - Norman; University of California System; University of California Berkeley; University of Chicago; National Bureau of Economic Research; Harvard University
摘要：The WHO recommends mass drug administration (MDA) for intestinal worm infections in areas with over 20% infection prevalence. Recent Cochrane meta- analyses endorse treatment of infected individuals but recommend against MDA. We conducted a theory- agnostic random- effects metaanalysis of the effect of multiple - dose MDA and a cost- effectiveness analysis. We estimate significant effects of MDA on child weight (0.15 kg, 95% CI: 0.07, 0.24; P < 0.001), mid - upper arm circumference (0.20 cm, 9...
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作者：Donker, Tjibbe; Papathanassopoulos, Alexis; Ghosh, Hiren; Kociurzynski, Raisa; Felder, Marius; Grundmann, Hajo; Reuter, Sandra
作者单位：University of Freiburg
摘要：The emergence of SARS-CoV-2 variants with increased fitness has had a strong impact on the epidemiology of COVID-19, with the higher effective reproduction number of the viral variants leading to new epidemic waves. Tracking such variants and their genetic signatures, using data collected through genomic surveillance, is therefore crucial for forecasting likely surges in incidence. Current methods of estimating fitness advantages of variants rely on tracking the changing proportion of a partic...
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作者：Dunwiddie, Peter; Stromberg, Caroline A. E.; Whitlock, Cathy
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Montana State University System; Montana State University Bozeman
摘要：Estella Leopold passed away in Seattle, Washington, on February 25th, 2024, at the age of 97. In a career spanning over six decades, she gained renown for her paleobotanical research of past environments during the Cenozoic Era (the last 66 million years) and for her unflinching efforts in environmental conservation. Her lifelong commitment to science, her delight in the natural world, and her dedication to conservation sprang from deep roots in her remarkable family and touched many. the youn...
