-
作者：Taeb, Armeen; Buhlmann, Peter; Chandrasekaran, Venkat
作者单位：University of Washington; University of Washington Seattle; California Institute of Technology; California Institute of Technology
摘要：In problems such as variable selection and graph estimation, models are characterized by Boolean logical structure such as the presence or absence of a variable or an edge. Consequently, false -positive error or false -negative error can be specified as the number of variables/edges that are incorrectly included or excluded in an estimated model. However, there are several other problems such as ranking, clustering, and causal inference in which the associated model classes do not admit transp...
-
作者：V. Koonin, Eugene
作者单位：National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM)
-
作者：Dikun, Krysta M.; Tang, Xiao- Han; Fu, Leiping; Choi, Mary E.; Lu, Changyuan; Gudas, Lorraine J.
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; NewYork-Presbyterian Hospital; Cornell University; Weill Cornell Medicine
摘要：Chronic kidney disease (CKD) is characterized by a gradual loss of kidney function and affects -13.4% of the global population. Progressive tubulointerstitial fibrosis, driven in part by proximal tubule (PT) damage, is a hallmark of late stages of CKD and contributes to the development of kidney failure, for which there are limited treatment options. Normal kidney development requires signaling by vitamin A (retinol), which is metabolized to retinoic acid (RA), an endogenous agonist for the RA...
-
作者：Wang, Xinke; Wang, Weihong; Wingen, Lisa M.; Perraud, Veronique; Finlayson-Pitts, Barbara J.
作者单位：University of California System; University of California Irvine
摘要：Emerging contaminants (EC) distributed on surfaces in the environment can be oxidized by gas phase species (top-down) or by oxidants generated by the underlying substrate (bottom-up). One class of EC is the neonicotinoid (NN) pesticides that are widely distributed in air, water, and on plant and soil surfaces as well as on airborne dust and building materials. This study investigates the OH oxidation of the systemic NN pesticide acetamiprid (ACM) at room temperature. ACM on particles and as th...
-
作者：Schonherr, Heike; Ayaz, Pelin; Taylor, Alexander M.; Casaletto, Jessica B.; Toure, B. Barry; Moustakas, Demetri T.; Hudson, Brandi M.; Valverde, Roberto; Zhao, Songping; O'Hearn, Patrick J.; Foster, Lindsey; Sharon, Dina A.; Garfinkle, Sam; Giordanetto, Fabrizio; Lescarbeau, Andre; Kurukulasuriya, Ravi; Gerami-Moayed, Nastaran; Maglic, Dejan; Bruderek, Kamil; Naik, Gaauri; Gunaydin, Hakan; Mader, Mary M.; Boezio, Alessandro A.; Mclean, Thomas H.; Chen, Rongfeng; Wang, Yanxia; Shaw, David E.; Watters, James; Bergstrom, Donald A.
作者单位：D. E. Shaw Research; Columbia University
摘要：Fibroblast growth factor receptor (FGFR) kinase inhibitors have been shown to be effective in the treatment of intrahepatic cholangiocarcinoma and other advanced solid tumors harboring FGFR2 alterations, but the toxicity of these drugs frequently leads to dose reduction or interruption of treatment such that maximum efficacy cannot be achieved. The most common adverse effects are hyperphosphatemia caused by FGFR1 inhibition and diarrhea due to FGFR4 inhibition, as current therapies are not sel...
-
作者：Lee, Seong-Kyun; Crosnier, Cecile; Valenzuela-Leon, Paola Carolina; Dizon, Brian L. P.; Atkinson, John P.; Mu, Jianbing; Wright, Gavin J.; Calvo, Eric; Gunalan, Karthigayan; Miller, Louis H.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University of York - UK; University of Hull; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); Washington University (WUSTL)
摘要：The discovery that Africans were resistant to infection by Plasmodium vivax (P. vivax) led to the conclusion that P. vivax invasion relied on the P. vivax Duffy Binding Protein (PvDBP) interacting with the Duffy Antigen Receptor for Chemokines (DARC) expressed on erythrocytes. However, the recent reporting of P. vivax infections in DARC- negative Africans suggests that the parasite might use an alternate invasion pathway to infect DARC-negative reticulocytes. To identify the parasite ligands a...
-
作者：Guzman, Marcelo; Guo, Xiaofei; Coulais, Corentin; Carpentier, David; Bartolo, Denis
作者单位：Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); University of Pennsylvania; University of Amsterdam
摘要：Topological materials can host edge and corner states that are protected from disorder and material imperfections. In particular, the topological edge states of mechanical structures present unmatched opportunities for achieving robust responses in wave guiding, sensing, computation, and filtering. However, determining whether a mechanical structure is topologically nontrivial and features topologically protected modes has hitherto relied on theoretical models. This strong requirement has limi...
-
作者：Scheibner, Colin; Ori, Hillel; Cohen, Adam E.; Vitelli, Vincenzo
作者单位：University of Chicago; University of Chicago; Harvard University; Harvard University; University of Chicago
摘要：Excitable media, ranging from bioelectric tissues and chemical oscillators to forest fires and competing populations, are nonlinear, spatially extended systems capable of spiking. Most investigations of excitable media consider situations where the amplifying and suppressing forces necessary for spiking coexist at every point in space. In this case, spikes arise due to local bistabilities, which require a fine-tuned ratio between local amplification and suppression strengths. But, in nature an...
-
作者：Jin, Meichi; Ding, Jingyi; Zhou, Yu; Chen, Jiazhao; Wang, Yi; Li, Zida
作者单位：Shenzhen University; Shenzhen University; Shenzhen University
摘要：Multiplex, digital nucleic acid detections have important biomedical applications, but probes, making the detection complicated and costly. Here, we present the StratoLAMP for label- free, multiplex digital loop- mediated isothermal amplification based on visual stratification of the precipitate byproduct. The StratoLAMP designates two sets of primers with different concentrations to achieve different precipitate yields when amplifying different nucleic acid targets. In the detection, deep lea...
-
作者：Guguchia, Z.; Das, D.; Simutis, G.; Adachi, T.; Kuespert, J.; Kitajima, N.; Elender, M.; Grinenko, V.; Ivashko, O.; Von Zimmermann, M.; Muellerh, M.; Mielke III, C.; Hotz, F.; Mudry, C.; Baines, C.; Bartkowiak, M.; Shiroka, T.; Koike, Y.; Amato, A.; Hicks, C. W.; Gu, G. D.; Tranquada, J. M.; Klauss, H-H; Chang, J. J.; Janoschek, M.; Luetkens, H.
作者单位：Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Sophia University; University of Zurich; Tohoku University; Shanghai Jiao Tong University; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; ETH Zurich; Max Planck Society; University of Birmingham; United States Department of Energy (DOE); Brookhaven National Laboratory; Technische Universitat Dresden
摘要：The ability to efficiently control charge and spin in the cuprate high-temperature superconductors is crucial for fundamental research and underpins technological development. Here, we explore the tunability of magnetism, superconductivity, and crystal structure in the stripe phase of the cuprate La2-xBaxCuO4, with x = 0.115 and 0.135, by employing temperature-dependent (down to 400 mK) muon-spin rotation and AC susceptibility, as well as X-ray scattering experiments under compressive uniaxial...
