2024

最新文章

• Ventilation does not affect close- range transmission of influenza virus in a ferret playpen setup AI翻译
  作者：Rockey, Nicole C.; Le Sage, Valerie; Shephard, Meredith; Vargas-Maldonado, Nahara; Vu, Michelle N.; Brown, Cambria A.; Patel, Krishna; French, Andrea J.; Merrbach, Grace A.; Walter, Sydney; Ferreri, Lucas M.; Holmes, Katie E.; Vaninsberghe, David; Clack, Herek L.; Prussin II, Aaron J.; Lowen, Anice C.; Marr, Linsey C.; Lakdawala, Seema S.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Emory University; University of Michigan System; University of Michigan; Virginia Polytechnic Institute & State University; Duke University
  摘要：Sustained community spread of influenza viruses relies on efficient person-to-person transmission. Current experimental transmission systems do not mimic environmental conditions (e.g., air exchange rates, flow patterns), host behaviors, or exposure durations relevant to real- world settings. Therefore, results from these traditional systems may not be representative of influenza virus transmission in humans. To address this pitfall, we developed a close-range transmission setup that implement...
• Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex AI翻译
  作者：Yuan, Xueying; Yan, Lu; Chen, Qinfu; Zhu, Shukai; Zhou, Xinyu; Zeng, Ling - Hui; Liu, Mingjie; He, Xiaojing; Huang, Jun; Lu, Weiguo; Zhang, Long; Yan, Haiyan; Wang, Fangwei
  作者单位：Zhejiang University; Zhejiang University; Hangzhou City University; Huazhong University of Science & Technology; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University
  摘要：The ring- shaped Cohesin complex, consisting of core subunits Smc1, Smc3, Scc1, and SA2 (or its paralog SA1), topologically entraps two duplicated sister DNA molecules to establish sister chromatid cohesion in S- phase. It remains largely elusive how the Cohesin release factor Wapl binds the Cohesin complex, thereby inducing Cohesin disassociation from mitotic chromosomes to allow proper resolution and separation of sister chromatids. Here, we show that Wapl uses two structural modules contain...
• Synthetic data can aid the analysis of clinical outcomes: How much can it be trusted? AI翻译
  作者：Adam, David
• The RPD3L deacetylation complex is required for facultative heterochromatin repression in Neurospora crassa AI翻译
  作者：Mumford, Colleen C.; Tanizawa, Hideki; Wiles, Elizabeth T.; McNaught, Kevin J.; Jamieson, Kirsty; Tsukamoto, Kenta; Selker, Eric U.
  作者单位：University of Oregon; Hokkaido University; University of California System; University of California Irvine; United States Department of Energy (DOE); Oak Ridge National Laboratory; Reed College - Portland
  摘要：Repression of facultative heterochromatin is essential for developmental processes in repressive complex 2 is a prominent feature of facultative heterochromatin in both fungi and higher eukaryotes. Although this methylation is frequently associated with silencing, the detailed mechanism of repression remains incompletely understood. We utilized a forward genetics approach to identify genes required to maintain silencing at facultative heterochromatin genes in Neurospora crassa and identified t...
• In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells AI翻译
  作者：Palanki, Rohan; Riley, John S.; Bose, Sourav K.; Luks, Valerie; Dave, Apeksha; Kus, Nicole; White, Brandon M.; Ricciardi, Adele S.; Swingle, Kelsey L.; Xue, Lulu; Sung, Derek; Thatte, Ajay S.; Safford, Hannah C.; Chaluvadi, Venkata S.; Carpenter, Marco; Han, Emily L.; Maganti, Rohin; Hamilton, Alex G.; Mrksich, Kaitlin; Billingsley, Margaret B.; Zoltick, Philip W.; Alameh, Mohamad- Gabriel; Weissman, Drew; Mitchell, Michael J.; Peranteau, William H.
  作者单位：University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
  摘要：Monogenic blood diseases are among the most common genetic disorders worldwide. These diseases result in significant pediatric and adult morbidity, and some can result in death prior to birth. Novel ex vivo hematopoietic stem cell (HSC) gene editing therapies hold tremendous promise to alter the therapeutic landscape but are not without potential limitations. In vivo gene editing therapies offer a potentially safer and more accessible treatment for these diseases but are hindered by a lack of ...
• With the leisure of time, kinetic proofreading can still perform reliable ligand discrimination AI翻译
  作者：Xiao, Fangzhou; Galstyan, Vahe
  作者单位：University of California System; University of California San Diego; AMOLF
• The impact of marriage equality campaigns on stress: Did a Swiss public vote get under the skin? AI翻译
  作者：Eisner, Leila; Fischer, Susanne; Juster, Robert- Paul; Hassler, Tabea
  作者单位：University of Zurich; Princeton University; Universite de Montreal
  摘要：Lesbian, gay, bisexual, trans, intersex, and queer (LGBTIQ+) individuals encounter persistent structural inequalities and discrimination that can lead to detrimental psychological and physiological health outcomes. Amid evolving legal landscapes, little attention has been directed toward understanding the physiological health effects of societal shifts on these communities. This study aims to explore the impact of a national marriage equality vote and associated debates on psychological and bi...
• Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making AI翻译
  作者：Hoy, Colin W.; de Hemptinne, Coralie; Wang, Sarah S.; Harmer, Catherine J.; Apps, Matthew A. J.; Husain, Masud; Starr, Philip A.; Little, Simon
  作者单位：University of California System; University of California San Francisco; State University System of Florida; University of Florida; State University System of Florida; University of Florida; University of Oxford; University of Oxford; University of Birmingham; University of Birmingham; University of Oxford; University of California System; University of California San Francisco
  摘要：Choosing whether to exert effort to obtain rewards is fundamental to human motivated behavior. However, the neural dynamics underlying the evaluation of reward and effort in humans is poorly understood. Here, we report an exploratory investigation into this with chronic intracranial recordings from the prefrontal cortex (PFC) and basal ganglia (BG; subthalamic nuclei and globus pallidus) in people with Parkinson's disease performing a decision- making task with offers that varied in levels of ...
• Directed evolution of material- producing microorganisms AI翻译
  作者：Laurent, Julie M.; Jain, Ankit; Kan, Anton; Steinacher, Mathias; Casimiro, Nadia Enrriquez; Stavrakis, Stavros; deMello, Andrew J.; Rogers, John
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Nature is home to a variety of microorganisms that create materials under environmentally friendly conditions. While this offers an attractive approach for sustainable manufacturing, the production of materials by native microorganisms is usually slow and synthetic biology tools to engineer faster microorganisms are only available when prior knowledge of genotype-phenotype links is available. Here, we utilize a high- throughput directed evolution platform to enhance the fitness of whole microo...
• Large language models for depression prediction AI翻译
  作者：Wang, Yu
  作者单位：Fudan University