Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making

• 成果类型: Article
• 署名作者: Hoy, Colin W.; de Hemptinne, Coralie; Wang, Sarah S.; Harmer, Catherine J.; Apps, Matthew A. J.; Husain, Masud; Starr, Philip A.; Little, Simon
• 署名单位: University of California System; University of California San Francisco; State University System of Florida; University of Florida; State University System of Florida; University of Florida; University of Oxford; University of Oxford; University of Birmingham; University of Birmingham; University of Oxford; University of California System; University of California San Francisco
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-10226
• DOI: 10.1073/pnas.2322869121
• 发表日期: 2024-07-30
• 关键词: deep brain-stimulation; subthalamic nucleus; orbitofrontal cortex; parkinsons-disease; subjective value; working-memory; frontal-cortex; cognitive map; motor imagery; dopamine

摘要

Choosing whether to exert effort to obtain rewards is fundamental to human motivated behavior. However, the neural dynamics underlying the evaluation of reward and effort in humans is poorly understood. Here, we report an exploratory investigation into this with chronic intracranial recordings from the prefrontal cortex (PFC) and basal ganglia (BG; subthalamic nuclei and globus pallidus) in people with Parkinson's disease performing a decision- making task with offers that varied in levels of reward and physical effort required. This revealed dissociable neural signatures of reward and effort, with BG beta (12 to 20 Hz) oscillations tracking effort on a single- trial basis and PFC theta (4 to 7 Hz) signaling previous trial reward, with no effects of net subjective value. Stimulation of PFC increased overall acceptance of offers and sensitivity to reward while decreasing the impact of effort on choices. This work uncovers oscillatory mechanisms that guide fundamental decisions to exert effort for reward across BG and PFC, supports a causal role of PFC for such choices, and seeds hypotheses for future studies.