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作者：Johnston, Phillip R.; Griffiths, John D.; Rokos, Leanne; Mcintosh, Anthony R.; Meltzer, Jed A.
作者单位：University of Toronto; University of Toronto; Baycrest; University of Toronto; Centre for Addiction & Mental Health - Canada; University of Toronto; University of Toronto; University of Toronto; Simon Fraser University; Simon Fraser University; University of Toronto
摘要：Stroke causes pronounced and widespread slowing of neural activity. Despite decades of work exploring these abnormal neural dynamics and their associated functional impairments, their causes remain largely unclear. To close this gap in understanding, we applied a neurophysiological corticothalamic circuit model to simulate magnetoencephalography (MEG) power spectra recorded from chronic stroke patients. Comparing model- estimated physiological parameters to those of controls, patients demonstr...
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作者：Killingsworth, Matthew A.; Kahneman, Daniel; Mellers, Barbara
作者单位：University of Pennsylvania
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作者：Hu, Xiaojing
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作者：Hu, Xu; Zhu, Qingyu; Lou, Tianjie; Hu, Qianqian; Li, Huashun; Xu, Yijia; Niu, Xiaojie; He, Li; Huang, Hao; Qiu, Mengsheng; Shen, Ying; Jia, Jie-Min; Tao, Yanmei
作者单位：Zhejiang University; Southeast University - China; Southeast University - China; Hangzhou Normal University; Westlake Laboratory; Westlake University; Zhejiang University
摘要：White matter (WM) abnormalities are an emerging feature of schizophrenia, yet the underlying pathophysiological mechanisms are largely unknown. Disruption of ErbB signaling, which is essential for peripheral myelination, has been genetically associated with schizophrenia and WM lesions in schizophrenic patients. However, the roles of ErbB signaling in oligodendrocytes remain elusive. Here, we used an in vivo pan-ErbB inhibition strategy and demonstrated the functions of endogenous ErbB recepto...
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作者：Li, Minle; Chen, Xuan; Qu, Pengfei; Shao, Zhiying; Shi, Lei; Quan, Haoyu; Zhao, Xue; Xu, Jian; Shi, Luling; Chen, Silu; Zheng, Junnian; Pan, Zhen-Qiang; Bai, Jin
作者单位：Xuzhou Medical University; Xuzhou Medical University; Nanjing Medical University; Xuzhou Medical University; Xuzhou Medical University; Icahn School of Medicine at Mount Sinai
摘要：Inflammatory bowel disease (IBD) is a considerable threat to human health with a significant risk for colorectal cancer (CRC). However, currently, both the molecular pathogenesis and therapeutic treatment of IBD remain limited. In this report, using both systemic and intestinal epithelium- specific gene knockout mouse models, we demonstrate that FBXO22, a substrate receptor within the SKP1- Cullin 1- F- box family of E3 ubiquitin ligases, plays an inhibitory role in the Azoxymethane/Dextran So...
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作者：Scur, Daniela; Ohlmacher, Scott; Van Reenen, John; Bennedsen, Morten; Bloom, Nick; Choudhary, Ali; Foster, Lucia; Groenewegen, Jesse; Grover, Arti; Hardeman, Sjoerd; Iacovone, Leonardo; Kambayashi, Ryo; Laible, Marie-Christine; Lemos, Renata; Li, Hongbin; Linarello, Andrea; Maliranta, Mika; Medvedev, Denis; Meng, Charlotte; Touya, John Miles; Mandirola, Natalia; Ohlsbom, Roope; Ohyama, Atsushi; Patnaik, Megha; Pereira-Lopez, Mariana; Sadun, Raffaella; Senga, Tatsuro; Qian, Franklin; Zimmermann, Florian
作者单位：Cornell University; Federal Reserve System - USA; Federal Reserve System Board of Governors; University of London; London School Economics & Political Science; University of Copenhagen; Stanford University; Loughborough University; Utrecht University; The World Bank; The World Bank; The World Bank; Stanford University; European Central Bank; Bank of Italy; University of London; Queen Mary University London; University of Barcelona; The National Land Survey of Finland; Finnish Geospatial Research Institute (FGI); Hitotsubashi University; Luiss Guido Carli University; Harvard University; University of North Carolina; University of North Carolina Chapel Hill
摘要：A country's national income broadly depends on the quantity and quality of workers and capital. But how well these factors are managed within and between firms may be a key determinant of a country's productivity and its GDP. Although social scientists have long studied the role of management practices in shaping business performance, their primary tool has been individual case studies. While useful for theory-building, such qualitative work is hard to scale and quantify. We present a large, s...
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作者：Lei, Min; Jin, Peng; Zhou, Yuhong; Li, Ying; Xu, Liujun; Huang, Jiping
作者单位：Fudan University; Fudan University; Zhejiang University; Zhejiang University; Zhejiang University; Chinese Academy of Engineering Physics
摘要：Thermal nonreciprocity plays a vital role in chip heat dissipation, energy-saving design, and high-temperature hyperthermia, typically realized through the use of advanced metamaterials with nonlinear, advective, spatiotemporal, or gradient properties. However, challenges such as fixed structural designs with limited adjustability, high energy consumption, and a narrow operational temperature range remain prevalent. Here, a systematic framework is introduced to achieve reconfigurable, zero-ene...
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作者：Xie, Hua; Illapani, Venkata Sita Priyanka; Reppert, Lauren T.; You, Xiaozhen; Krishnamurthy, Manu; Bai, Yutong; Berl, Madison M.; Gaillard, William D.; Hong, Seok - Jun; Sepeta, Leigh N.
作者单位：Children's National Health System; George Washington University; Sungkyunkwan University (SKKU); Institute for Basic Science - Korea (IBS); George Washington University
摘要：The hippocampus is functionally specialized along its longitudinal axis with intricate interactions with cortical systems, which is crucial for understanding development and cognition. Using a well- established connectopic mapping technique on two large resting- state functional MRI datasets, we systematically quantified topographic organization of the hippocampal functional connectivity (hippocampal gradient) and its cortical interaction in developing brains. We revealed hippocampal functiona...
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作者：Somers, Shane E.; Davidson, Gabrielle L.; Mbandlwa, Philiswa; Mckeon, Caroline M.; Stanton, Catherine; Ross, R. Paul; Quinn, John L.
作者单位：University College Cork; University College Cork; University of East Anglia; Teagasc; Agri-Food & Biosciences Institute; Trinity College Dublin; University College Cork
摘要：Empirical studies from laboratory systems and humans show that the gut microbiota is linked to host health. Similar evidence for effects on traits linked to fitness in nature is rare, not least because experimentally manipulating the gut microbiota is challenging. We isolated, characterized, and cultured a bacterial strain, Lactobacillus kimchicus APC4233, directly from a wild bird (the great tit Parus major) and provided it as a self- administered dietary supplement. We assessed the impact of...
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作者：Cao, Yang; Zhang, Qiaozhi; Yu, Iris K. M.; Tsang, Daniel C. W.
作者单位：Hong Kong Polytechnic University; National University of Singapore; Hong Kong University of Science & Technology
摘要：Catalytic oxidation through the transfer of lattice oxygen from metal oxides to reactants, namely the Mars-van Krevelen mechanism, has been widely reported. In this study, we evidence the overlooked oxidation route that features the in situ formation of surface OH species on Cu catalysts and its selective addition to the reactant carbonyl group. We observed that glucose oxidation to gluconic acid in air (21% O2) was favored on low- valence Cu sites according to X- ray spectroscopic analyses. M...
