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作者：Fan, Xingwang; Zhang, Yunlin; Shi, Kun; Peng, Jian; Liu, Yongwei; Zhou, Yongqiang; Liu, Yuanbo; Zhu, Qing; Song, Chunqiao; Wan, Rongrong; Zhao, Xiaosong; Woolway, R. Iestyn
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geography & Limnology, CAS; Chinese Academy of Sciences; Nanjing Institute of Geography & Limnology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Nanjing Institute of Geography & Limnology, CAS; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Leipzig University; Bangor University
摘要：Compound drought-heatwaves (CDHWs) accelerate the warming and drying of soils, triggering soil compound drought-heatwaves (SCDHWs) that jeopardize the health of soil ecosystems. Nevertheless, the behavior of these events worldwide and their responses to climatic warming are underexplored. Here, we show a global escalation in the frequency, duration, peak intensity, and severity of SCDHWs, as well as an increase in affected land area, from 1980 to 2023. The increasing trends, which are particul...
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作者：Yang, Kou; Nikolaev, Konstantin G.; Li, Xiaolai; Ivanov, Artemii; Bong, Jia Hui; Erofeev, Ivan; Mirsaidov, Utkur M.; Kravets, Vasyl G.; Grigorenko, Alexander N.; Zhang, Shanqing; Qiu, Xueqing; Novoselov, Kostya S.; V. Andreeva, Daria
作者单位：National University of Singapore; Institute for Functional Intelligent Materials (I-FIM); Guangdong University of Technology; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; University of Manchester
摘要：The extraction of gold (Au) from electronic waste (e- waste) has both environmental impact and inherent value. Improper e- waste disposal poses environmental and health risks, entailing substantial remediation and healthcare costs. Large efforts are applied for the recovery of Au from e- waste using complex processes which include the dissolution of Au, its adsorption in an ionic state and succeeding reduction to metallic Au. These processes themselves being complex and utilizing harsh chemica...
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作者：Lin, Baihan; Kriegeskorte, Nikolaus
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Columbia University; Columbia University; Columbia University
摘要：A central question for neuroscience is how to characterize brain representations of perceptual and cognitive content. An ideal characterization should distinguish different functional regions with robustness to noise and idiosyncrasies of individual brains that do not correspond to computational differences. Previous studies have characterized brain representations by their representational geometry, which is defined by the representational dissimilarity matrix (RDM), a summary statistic that ...
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作者：Oluwole, Abraham O.; Kalmankar, Neha V.; Guida, Michela; Bennett, Jack L.; Poce, Giovanna; Bolla, Jani R.; Robinson, Carol V.
作者单位：University of Oxford; University of Oxford; Sapienza University Rome; University of Oxford
摘要：The peptidoglycan pathway represents one of the most successful antibacterial targets with the last critical step being the flipping of carrier lipid, undecaprenyl phosphate (C-55-P), across the membrane to reenter the pathway. This translocation of C-55-P is facilitated by DedA and DUF368 domain-containing family membrane proteins via unknown mechanisms. Here, we employ native mass spectrometry to investigate the interactions of UptA, a member of the DedA family of membrane protein from Bacil...
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作者：Asor, Roi; Olerinyova, Anna; Burnap, Sean A.; Kushwah, Manish S.; Soltermann, Fabian; Rudden, Lucas S. P.; Hensen, Mario; Vasiljevic, Snezana; Brun, Juliane; Hill, Michelle; Chang, Liu; Dejnirattisai, Wanwisa; Supasa, Piyada; Mongkolsapaya, Juthathip; Zhou, Daming; Stuart, David I.; Screaton, Gavin R.; Degiacomi, Matteo T.; Zitzmann, Nicole; Benesch, Justin L. P.; Struwe, Weston B.; Kukura, Philipp
作者单位：University of Oxford; University of Oxford; University of Oxford; Durham University; University of Oxford; Wellcome Centre for Human Genetics; Chinese Academy of Medical Sciences - Peking Union Medical College; University of Oxford; Mahidol University; University of Oxford; Wellcome Centre for Human Genetics; Oxford University Hospitals NHS Foundation Trust
摘要：Cellular processes are controlled by the thermodynamics of the underlying biomolecular interactions. Frequently, structural investigations use one monomeric binding partner, while ensemble measurements of binding affinities generally yield one affinity representative of a 1:1 interaction, despite the majority of the proteome consisting of oligomeric proteins. For example, viral entry and inhibition in SARS- CoV- 2 involve cell- surface receptor and dimeric antibodies. Here, we reveal that coop...
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作者：Ma, Yayao; Park, Jongchan; Huang, Luzhe; Sen, Chandani; Burri, Samuel; Bruschini, Claudio; Yang, Xilin; Cui, Qi; Cameron, Robert B.; Fishbein, Gregory A.; Gomperts, Brigitte N.; Ozcan, Aydogan; Charbon, Edoardo; Gao, Liang
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Fluorescence lifetime imaging microscopy (FLIM) is a powerful imaging technique that enables the visualization of biological samples at the molecular level by measuring the fluorescence decay rate of fluorescent probes. This provides critical information about molecular interactions, environmental changes, and localization within biological systems. However, creating high- resolution lifetime maps using conventional FLIM systems can be challenging, as it often requires extensive scanning that ...
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作者：Subramanian, Sandya; Tseng, Bryan; del Carmen, Marcela; Goodman, Annekathryn; Dahl, Douglas M.; Barbieri, Riccardo; Brown, Emery N.
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Polytechnic University of Milan
摘要：Monitoring nociception, the flow of information associated with harmful stimuli through the nervous system even during unconsciousness, is critical for proper anesthesia care during surgery. Currently, this is done by tracking heart rate and blood pressure by eye. Monitoring objectively a patient's nociceptive state remains a challenge, causing drugs to often be over- or underdosed intraoperatively. Inefficient management of surgical nociception may lead to more complex postoperative pain mana...
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作者：Yamashita, Yu; Hayakawa, Harumi; Wang, Pushi; Makita, Tatsuyuki; Kumagai, Shohei; Watanabe, Shun; Takeya, Jun
作者单位：University of Tokyo; University of Tokyo; National Institute for Materials Science; Institute of Science Tokyo; Tokyo Institute of Technology
摘要：Thin-film devices that transduce the chemical activity of ions into electronic signals are essential components in various applications, including healthcare diagnostics and environmental monitoring. Combinations of organic semiconductors (OSCs) and ion- selective materials have been explored for developing solution-processable ion sensors. However, the necessity of reference electrodes (REs) and operational stability in ion- permeable OSCs have posed questions regarding whether reliable measu...
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作者：Bhattacharya, Rachita; Kumari, Jaya; Banerjee, Shweta; Tripathi, Jyoti; Parihar, Saurabh Singh; Mohan, Nitin; Sinha, Pradip
作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur
摘要：Mammalian Yes- associated protein (YAP) and transcriptional coactivator with PDZ- binding motif (TAZ) and Drosophila Yorkie (Yki) are transcription cofactors of the highly conserved Hippo signaling pathway. It has been long assumed that the YAP/TAZ/Yki signaling drives cell proliferation during organ growth. However, its instructive role in regulating developmentally programmed organ growth, if any, remains elusive. Out- of- context gain of YAP/TAZ/Yki signaling often turns oncogenic. Paradoxi...
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作者：Tuffet, Remi; Carvalho, Gabriel; Godeux, Anne-Sophie; Mazzamurro, Fanny; Rocha, Eduardo P. C.; Laaberki, Maria-Halima; Venner, Samuel; Charpentier, Xavier
作者单位：Ecole Normale Superieure de Lyon (ENS de LYON); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); VetAgro Sup; Universite Claude Bernard Lyon 1; VetAgro Sup; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Sorbonne Universite
摘要：The opportunistic pathogen Acinetobacter baumannii, carries variants of A. baumannii resistance islands (AbaR)- type genomic islands conferring multidrug resistance. Their pervasiveness in the species has remained enigmatic. The dissemination of AbaRs is intricately linked to their horizontal transfer via natural transformation, a process through which bacteria can import and recombine exogenous DNA, effecting allelic recombination, genetic acquisition, and deletion. In experimental population...
