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作者：Jiang, Xunheng; Zhou, Binghui; Yang, Weijie; Chen, Jiayi; Miao, Chen; Guo, Zhongyuan; Li, Hao; Hou, Yang; Xu, Xinhua; Zhu, Lizhong; Lin, Daohui; Xu, Jiang
作者单位：Zhejiang University; North China Electric Power University; Zhejiang University; Tohoku University; Zhejiang University
摘要：Nonradicals are effective in selectively degrading electron- rich organic contaminants, which unfortunately suffer from unsatisfactory yield and uncontrollable composition due to the competitive generation of radicals. Herein, we precisely construct a local microenvironment of the carbon nitride-supported high- loading (similar to 9 wt.%) Fe single- atom catalyst (Fe SAC) with sulfur via a facile supermolecular self- assembly strategy. Short- distance S coordination boosts the peroxymonosulfat...
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作者：Sibille, Jeremie; Gehr, Carolin; Kremkow, Jens
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin
摘要：The thalamus provides the principal input to the cortex and therefore understanding the mechanisms underlying cortical integration of sensory inputs requires to characterize the thalamocortical connectivity in behaving animals. Here, we propose tangential insertions of high-density electrodes into mouse cortical layer 4 as a method to capture the activity of thalamocortical axons simultaneously with their synaptically connected cortical neurons. This technique can reliably monitor multiple par...
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作者：Yoo, Tae Yeon; Mitchison, Timothy J.
作者单位：Harvard University; Harvard Medical School
摘要：Open Reading Frame 6 (ORF6) proteins, which are unique to severe acute respiratory syndrome-related (SARS) coronavirus, inhibit the classical nuclear import pathway to antagonize host antiviral responses. Several alternative models were proposed to explain the inhibitory function of ORF6 [H. Xia et al., Cell Rep. 33, 108234 (2020); L. Miorin et al., Proc. Natl. Acad. Sci. U.S.A. 117, 28344-28354 (2020); and M. Frieman et al., J. Virol. 81, 9812-9824 (2007)]. To distinguish these models and bui...
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作者：Mora, Elisa Heinrich; Denton, Kaleda K.; Palmer, Michael E.; Feldman, Marcus W.
作者单位：Stanford University; The Santa Fe Institute
摘要：Models of conformity and anticonformity have typically focused on cultural traits with unordered variants, such as baby names, strategies (cooperate/defect), or the presence/absence of an innovation. There have been fewer studies of conformity to cultural traits with ordered variants, such as level of cooperation (low, medium, high) or proportion of time spent on a task (0% to 100%). In these studies of ordered cultural traits, conformity is defined as a preference for the mean trait value in ...
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作者：Gilboa, Tal; Swank, Zoe; Thakur, Rohan; Gould, Russell A.; Ooi, Kean Hean; Norman, Maia; Flynn, Elizabeth A.; Deveney, Brendan T.; Chen, Anqi; Borberg, Ella; Kuzkina, Anastasia; Ndayisaba, Alain; Khurana, Vikram; Weitz, David A.; Walt, David R.
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University; Harvard Medical School; Harvard University; Harvard University; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University
摘要：The quantification and characterization of aggregated alpha-synuclein in clinical samples offer immense potential toward diagnosing, treating, and better understanding neuro-degenerative synucleinopathies. Here, we developed digital seed amplification assays to detect single alpha-synuclein aggregates by partitioning the reaction into microcompartments. Using pre-formed alpha-synuclein fibrils as reaction seeds, we measured aggregate concentrations as low as 4 pg/mL. To improve our sensitivity...
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作者：Liu, Yiwei; McQuillen, Eleanor A.; Rana, Pranav S. J. B.; Gloag, Erin S.; Parsek, Matthew R.; Wozniak, Daniel J.
作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Virginia Polytechnic Institute & State University; University of Washington; University of Washington Seattle
摘要：Bacterial infections are often polymicrobial. Pseudomonas aeruginosa and Staphylococcus aureus cause chronic co- infections, which are more problematic than mono- species infections. Understanding the mechanisms of their interactions is crucial for treating co- infections. Staphyloxanthin (STX), a yellow pigment synthesized by the S. aureus crt operon, promotes S. aureus resistance to oxidative stress and neutrophil- mediated killing. We found that STX production by S. aureus, either as surfac...
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作者：Najma, Bibi; Wei, Wei- Shao; Baskaran, Aparna; Foster, Peter J.; Duclos, Guillaume
作者单位：Brandeis University; University of Southern California
摘要：Microtubules and molecular motors are essential components of the cellular cytoskeleton, driving fundamental processes in vivo, including chromosome segregation and cargo transport. When reconstituted in vitro, these cytoskeletal proteins serve as energy- consuming building blocks to study the self- organization of active matter. Cytoskeletal active gels display rich emergent dynamics, including extensile flows, locally contractile asters, and bulk contraction. However, it is unclear how the p...
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作者：Raty, Jean -Yves; Bichara, Christophe; Schoen, Carl-Friedrich; Gatti, Carlo; Wuttig, Matthias
作者单位：University of Liege; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Aix-Marseille Universite; RWTH Aachen University; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze Tecnologie Chimiche Giulio Natta (SCITEC-CNR); Helmholtz Association; Research Center Julich
摘要：Glasses are commonly described as disordered counterparts of the corresponding crystals; both usually share the same short -range order, but glasses lack long -range order. Here, a quantification of chemical bonding in a series of glasses and their corresponding crystals is performed, employing two quantum- chemical bonding descriptors, the number of electrons transferred and shared between adjacent atoms. For popular glasses like SiO2, GeSe2, and GeSe, the quantum- chemical bonding descriptor...
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作者：Bednarek, Angela T.; Miyamoto, Ben; Corbett, Kristin; Hudson, Charlotte; Scarrow, Gayle; Brass, Maeghan; Dumont, Kim; Holmes, Bev; Supplee, Lauren; Mclean, Robert; Bhatia, Jaspal; Chappell, Shamira; Velez, Maggie Gorman; Kolavalli, Chhaya
作者单位：National Oceanic Atmospheric Admin (NOAA) - USA; University of Michigan System; University of Michigan; American Institutes for Research
摘要：Research that better aligns policy, practice, and research communities is gaining momentum around the world. This includes engaged research strategies that bring partners, and their diverse perspectives and kinds of knowledge, together to shape research agendas with on- the- ground- needs and to create dynamic problem- solving processes. These approaches aim to generate more equitable and effective solutions to societal challenges. Although many of these partnered strategies have a longstandin...
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作者：Nava, Hernaldo Mendoza; Holderied, Marc W.; Pirrera, Alberto; Groh, Rainer M. J.
