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作者：Young, Paul G.; Levring, Jesper; Fiedorczuk, Karol; Blanchard, Scott C.; Chen, Jue
作者单位：Rockefeller University; St Jude Children's Research Hospital; Rockefeller University; Howard Hughes Medical Institute
摘要：The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that regulates electrolyte and fluid balance in epithelial tissues. While activation of CFTR is vital to treating cystic fibrosis, selective inhibition of CFTR is a potential therapeutic strategy for secretory diarrhea and autosomal dominant polycystic kidney disease. Although several CFTR inhibitors have been developed by high- throughput screening, their modes of action remain elusive. In this study, we determ...
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作者：Liu, Wenjing; Zhang, Chang; Zhang, Huawei; Ma, Shaojie; Deng, Jing; Wang, Daping; Chang, Ziwei; Yang, Jun
作者单位：Chinese Academy of Sciences; Innovation Academy for Precision Measurement Science & Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Southern University of Science & Technology; Shenzhen University; Wuhan University of Science & Technology
摘要：The self- assembly of proteins into curved structures plays an important role in many cellular processes. One good example of this phenomenon is observed in the septum- forming protein (SepF), which forms polymerized structures with uniform curvatures. SepF is essential for regulating the thickness of the septum during bacteria cell division. In Bacillus subtilis, SepF polymerization involves two distinct interfaces, the (3-(3 and alpha-alpha interfaces, which define the assembly unit and cont...
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作者：Paim, Lia Mara Gomes; Jauregui, Azriel Abraham Lopez-; Mcalear, Thomas S.; Bechstedt, Susanne
作者单位：McGill University
摘要：Regulation of microtubule dynamics by microtubule- associated proteins (MAPs) is essential for mitotic spindle assembly and chromosome segregation. Altered microtubule dynamics, particularly increased microtubule growth rates, were found to be a contributing factor for the development of chromosomal instability, which potentiates tumorigenesis. The MAP XMAP215/CKAP5 is the only known microtubule growth factor, and whether other MAPs regulate microtubule growth in cells is unclear. Our recent i...
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作者：Al Turkestani, Najla; Li, Tengfei; Bianchi, Jonas; Gurgel, Marcela; Prieto, Juan; Shah, Hina; Benavides, Erika; Soki, Fabiana; Mishina, Yuji; Fontana, Margherita; Rao, Arvind; Zhu, Hongtu; Cevidanes, Lucia
作者单位：King Abdulaziz University; University of Michigan System; University of Michigan; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of the Pacific; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：Temporomandibular joint osteoarthritis (TMJ OA) is a prevalent degenerative disease characterized by chronic pain and impaired jaw function. The complexity of TMJ OA has hindered the development of prognostic tools, posing a significant challenge in timely, patient- specific management. Addressing this gap, our research employs a comprehensive, multidimensional approach to advance TMJ OA prognostication. We conducted a prospective study with 106 subjects, 74 of whom were followed up after 2 to...
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作者：Yang, Ya-Chi; Wang, Guan- Hsun; Chou, Ping; Hsueh, Shu- Wei; Lai, Yi- Chen; Kuo, Chung-Chin
作者单位：Chang Gung University; Chang Gung University; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; National Taiwan University; National Taiwan University; National Taiwan University Hospital
摘要：One of the very fundamental attributes for telencephalic neural computation in mammals involves network activities oscillating beyond the initial trigger. The continuing and automated processing of transient inputs shall constitute the basis of cognition and intelligence but may lead to neuropsychiatric disorders such as epileptic seizures if carried so far as to engross part of or the whole telencephalic system. From a conventional view of the basic design of the telencephalic local circuitry...
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作者：Chakrabarti, Rajshree; Verma, Lakshmanji; Hadjiev, Viktor G.; Palmer, Jeremy C.; Vekilov, Peter G.
作者单位：University of Houston System; University of Houston; University of Houston System; University of Houston; University of Houston System; University of Houston
摘要：The growth rates of crystals are largely dictated by the chemical reaction between solute and kinks, in which a solute molecule severs its bonds with the solvent and establishes new bonds with the kink. Details on this sequence of bond breaking and rebuilding remain poorly understood. To elucidate the reaction at the kinks we employ four solvents with distinct functionalities as reporters on the microscopic structures and their dynamics along the pathway into a kink. We combine time- resolved ...
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作者：Ishizawa, Hidehiro; Tashiro, Yosuke; Inoue, Daisuke; Ike, Michihiko; Futamata, Hiroyuki
作者单位：University of Hyogo; Shizuoka University; Shizuoka University; Shizuoka University; University of Osaka
摘要：Understanding the assembly of multispecies microbial communities represents a significant challenge in ecology and has wide applications in agriculture, wastewater treatment, and human healthcare domains. Traditionally, studies on the microbial community assembly focused on analyzing pairwise relationships among species; however, neglecting higher - order interactions, i.e., the change of pairwise relationships in the community context, may lead to substantial deviation from reality. Herein, w...
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作者：Reinertsen, Roger J. E.; Kewalramani, Sumit; Jimenez-Angeles, Felipe; Weigand, Steven J.; Bedzyk, Michael J.; de la Cruz, Monica Olvera
作者单位：Northwestern University; United States Department of Energy (DOE); Argonne National Laboratory; Northwestern University; Northwestern University; Northwestern University; Northwestern University
摘要：Electrostatic forces in solutions are highly relevant to a variety of fields, ranging from electrochemical energy storage to biology. However, their manifestation in concentrated electrolytes is not fully understood, as exemplified by counterintuitive observations of colloidal stability and long - ranged repulsions in molten salts. Highly charged biomolecules, such as DNA, respond sensitively to ions in dilute solutions. Here, we use non- base- pairing DNA- coated nanoparticles (DNA - NP) to a...
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作者：Sammons, Rosanna P.; Vezir, Mourat; Moreno-Velasquez, Laura; Cano, Gaspar; Orlando, Marta; Sievers, Meike; Grasso, Eleonora; Metodieva, Verjinia D.; Kempter, Richard; Schmidt, Helene; Schmitz, Dietmar
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Humboldt University of Berlin; Max Planck Society; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; Max Delbruck Center for Molecular Medicine
摘要：The hippocampal formation is crucial for learning and memory, with submodule CA3 thought to be the substrate of pattern completion. However, the underlying synaptic and computational mechanisms of this network are not well understood. Here, we perform circuit reconstruction of a CA3 module using three dimensional (3D) electron microscopy data and combine this with functional connectivity recordings and computational simulations to determine possible CA3 network mechanisms. Direct measurements ...
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作者：Angert, Amy L.
作者单位：University of British Columbia
